DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and Hace1

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	XP_006512697.1	Gene:	Hace1 / 209462	MGIID:	2446110	Length:	921	Species:	Mus musculus

Alignment Length:	861	Identity:	177/861 - (20%)
Similarity:	308/861 - (35%)	Gaps:	245/861 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  2326 VLPYNMTVYQAVKQFSPLVSEQPETDNESETLLGNASIWVQQHTIHYRPVEE-EVTSGAAAGAAS 2389
            ::.|:..::|.:.|.:           ::|.|..|....|.||.......:. ::.:|.|..|.:
Mouse   260 LIQYHPRLFQTIVQMT-----------QNEDLRENMLRQVLQHLSQQSESQYLKILTGLAEVATT 313

  Fly  2390 SSS---SCSSGVQKQQSSSSSASS--C-VNATSSCSSSSGVASG-GGSLTKKAHKSSSKFMRKKT 2447
            :..   |.||....|..|......  | |......|.|:|:..| .|:.|.:     |:..:...
Mouse   314 NGHKLLSLSSNYDAQMKSLLRIVRIFCHVFRIGPSSPSNGIDMGYNGNKTPR-----SQVFKPLE 373

  Fly  2448 ELWHEGIAPVVISALKPFLSSSLPADVVTV------QDASLDALCMLRVIHALNRHWDHLYGCVV 2506
            .|||.....:|:.|.:...:.....|:.::      ||....:|      .|........|
Mouse   374 LLWHSLDEWLVLIATELMKNKEDSTDITSILLKQKGQDQEAPSL------SAFEPPGPGSY---- 428

  Fly  2507 RQNIIPQSDFIHPKIMA---KANRQLQDPLVIMTGNLPQWLPQIGMAC----------PFLFPFE 2558
             :::.|......|:::|   :|:...||.:.:....|...:....|.|          |....|.
Mouse   429 -ESLPPGPGDSKPEVLAGEQEASADCQDVISVTANRLSAVIQAFYMCCSCQMPPGMTSPRFIEFV 492

  Fly  2559 TRHLLFYATSFDRDRALQRLLDTTPDLNAAESSERVAPRLDRRKRAISRTEILKQAEHIL--QDF 2621
            .:|          |..|:..::..|.:           ..|.....:...|::.:..||:  |.|
Mouse   493 CKH----------DEVLKCFVNRNPKI-----------IFDHFHFLLECPELMSRFMHIIKAQPF 536

  Fly  2622 GHSKALLEIQYENEVGTGLGPTLEFYALVSAELQRTDLGLWNGSDSYKQNSVTIVDVVKANSAVL 2686
               |...|..||: :.:| .|..:   :|...:...|:.|.: .||..::|..||.  |||.|.|
Mouse   537 ---KDRCEWFYEH-LHSG-QPDSD---MVHRPVSENDILLVH-RDSIFRSSCEIVS--KANCAKL 590

  Fly  2687 HIEDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQHQHPPTRSSSRSHVLRSGAGQQPVEHSS 2751
            ....|:                                         |.|
Mouse   591 KQGIAV-----------------------------------------RFH--------------- 599

  Fly  2752 SSAGANENALNMVIAQQFSDTNS---ANPAAIDNPSSTTTAT-TVVQHNTTTNNSSIITTTTTTS 2812
                 .|..:...:.:::.|..|   .||   |....|.:|. |..|.|             :.|
Mouse   600 -----GEEGMGQGVVREWFDILSNEIVNP---DYALFTQSADGTTFQPN-------------SNS 643

  Fly  2813 YVHAVHGLFPLPLGKSSKLPQMTKAKAKFKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSI 2877
            ||:..|..:                   |:|.|:.:..|:...:::::.|:..||:      |.:
Mouse   644 YVNPDHLNY-------------------FRFAGQILGLALNHRQLVNIYFTRSFYK------HIL 683

  Fly  2878 GL----ADLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDAMEKTEKIEQLDLDGCPIADLGLDF 2938
            |:    .|:..:.||....|          ::||.:                    .|:||||:.
Mouse   684 GIPVNYQDVASIDPEYAKNL----------QWILDN--------------------DISDLGLEL 718

  Fly  2939 -------VLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFEALREGFDSVFPIQ 2996
                   |......:.|..||....||.:|..:|:.|||...:...:|.|..|..:||....|..
Mouse   719 TFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPS 783

  Fly  2997 RLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDH--GFHQDSQAIQYLYEILASYNRDEQ 3059
            .:::|...|||.:..|. .|...:.| ||      .|::  |:.::...||:.:|::....::|:
Mouse   784 LIQLFDEYELELLLSGM-PEIDVNDW-IK------NTEYTSGYEREDPVIQWFWEVVEDITQEER 840

  Fly  3060 RAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSVMTCVNYLKLPDYSSREVMRQ 3124
            ...|||||||.|:|.|||..:.....:...|:.......:.||:..||:|.||||:|.|:|:::.
Mouse   841 VLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKD 905

  Fly  3125 KLKVAANEGSMSFHLS 3140
            :|.||.:.||..:.::
Mouse   906 RLLVALHCGSYGYTMA 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	83/332 (25%)
Hace1	XP_006512697.1	ANK repeat	66..95	CDD:293786
		Ank_2	69..194	CDD:372319
		ANK repeat	97..128	CDD:293786
		ANK repeat	130..161	CDD:293786
		ANK repeat	163..194	CDD:293786
		Ank_2	168..263	CDD:372319	0/2 (0%)
		ANK repeat	196..233	CDD:293786
		HECTc	566..915	CDD:238033	109/491 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900