DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ctrip and yap-1

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_001369894.1	Gene:	yap-1 / 181267	WormBaseID:	WBGene00008748	Length:	442	Species:	Caenorhabditis elegans

Alignment Length:	437	Identity:	88/437 - (20%)
Similarity:	143/437 - (32%)	Gaps:	120/437 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   564 RSSNSNSSNNVVDYSIMPHLTTVATTTPHALTP------QQHQQQRQPPQPPSHQQQQVHQQQQP 622
            :....||..:...:|:..:|.  ...:.|||..      :::|.|::.|.|.|:    .||::.|
Worm     8 KKHQENSQQDKNQFSVHHYLD--PNQSIHALISCSEKKYEKNQNQKKNPLPSSY----YHQKRNP 66

  Fly   623 PQLLPTHQFAHLSSFVTPTAAAAAAAAAAHYPP---ASAAAAYFAQQQHHQHQHQHQQQHVQQAQ 684
            .           ||..:|..:...::..|..|.   .|..|....:|....:.|.........|.
Worm    67 G-----------SSAHSPYGSVDESSRTAVSPAMDMVSNQAPIHTRQVSAPNLHTSVNNGQSSAT 120

  Fly   685 APQP-----HYYHS-SVAVL-----HQPPPHH---------FTSTGAGPPPALFQQQAPPQLTRY 729
            .|.|     |:.|| ||:.|     :.|.|.|         ::..|....|   |||...|..|.
Worm   121 VPHPSHHNVHHQHSKSVSALPMTIGYSPVPSHVKSVSHEANYSYAGLSEIP---QQQGMMQQNRE 182

  Fly   730 TPATA-TTAATFVPPQQQQVVYNPQQQQHSSLRRSSRGKTGSCVSSAAAAQQQQHHQQ------- 786
            ...:. .....|:.||..:.:..||..:             .|..|......:.|:.:
Worm   183 KSLSLDPMRRPFMTPQDVEQLPMPQGWE-------------MCYDSDGVRYFKDHNSKTTTWDDP 234

  Fly   787 --QQHSSAAAAVQQQLLPPPGTYQYQQVGGNTVVVAVRHQQQLQQQQQQQQQLALHHQHQQQQHQ 849
              :|.......:.:.:    |..:|.....|      .|..:......|.||:..:|...|...|
Worm   235 RLKQQEQTGFGLGENI----GQNRYNNCYDN------GHSSRSLPSIHQHQQMIPNHPQPQYSSQ 289

  Fly   850 QQQQQHQQQQHQ----QQQRATLVQPGFL------------------------FSYRSNQP---Q 883
            ||....||.|::    |::.|.|:..|.:                        |.|:..|.   .
Worm   290 QQMDYIQQLQNERMMIQEKNAQLINSGLVDSPQPPYQAISPMSSTMMHSHDPNFMYQQQQQAQNS 354

  Fly   884 QQQQPAQQIHQGPKVTHSSAASD----ALTYSLMA---QQPPSGPPH 923
            ||||....:||.|....:|..:|    .:.||:::   |......||
Worm   355 QQQQTPHTLHQIPNQYQNSQMNDDSAMEVDYSMVSHPQQLQHQHQPH 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669	17/62 (27%)
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058
yap-1	NP_001369894.1	WW	206..236	CDD:238122	5/42 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900