DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ctrip and hecd-1

DIOPT Version :9

Sequence 1:NP_001189170.1 Gene:ctrip / 40596 FlyBaseID:FBgn0260794 Length:3140 Species:Drosophila melanogaster
Sequence 2:NP_001368365.1 Gene:hecd-1 / 177486 WormBaseID:WBGene00016405 Length:2650 Species:Caenorhabditis elegans


Alignment Length:2547 Identity:529/2547 - (20%)
Similarity:843/2547 - (33%) Gaps:835/2547 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   913 MAQQPPSGPPHA-------GGQQITP-GANSANLSIVAAALSAARDV--------GGGSDGGGSA 961
            ||::||.|....       |..::|| ..:..|....:.|:..|.|:        .||:|...::
 Worm   620 MAKEPPKGLEEVLNAIHLEGRSRVTPMEIDFENQPSSSTAVPTANDIMDTTVPSSSGGADAESNS 684

  Fly   962 GGAT-----PATGASASSVGNTSA---VGASSSSNSSAGQAASSNSNNVTATGSGSAPGGGPTST 1018
            ..:|     |.:...:||...:.:   ..|||:::|:..|..|..|:..:...|.:|....||.|
 Worm   685 NPSTIEMADPESSTPSSSTQQSISKPKATASSTASSAILQVVSKLSSVASLDKSAAAVDKKPTKT 749

  Fly  1019 -----------------GTTS-------------------------GTQHGSGSGAAAAVDSESD 1041
                             ||||                         ...|.......|:||.:..
 Worm   750 VLSQGTPYRWKEWRIVRGTTSLFIWSDVLLIELPFQSNGWFRYLADNDSHVQFVTGTASVDQQMT 814

  Fly  1042 DSE------------VGRLQAL------------LEARGLPPHLFGALGPRVTHILHRTIGNSSS 1082
            :.|            |.|..|:            :...|:|.:     ..:|:..|........|
 Worm   815 EEEKDNFQKTERREMVSRWNAVKGVFDDDWSSVPIAVLGIPSN-----AKKVSQKLEVPAWELWS 874

  Fly  1083 SKANQL-LQGLQSHDESQQLQAAIEMCQMLVMGNEDTLAGFPIK-------QVVPALIQLLRMEH 1139
            ||:::| ::.:.|...:.|....:...::     :|...||..:       .|:|        ||
 Worm   875 SKSSELQIKSISSSAPTGQANTMLTTIKI-----QDDAGGFLFETGTGRKTNVMP--------EH 926

  Fly  1140 NFDIMNNACRALAYMLEALPRSSGTVVEAVPVFLEKLQVIQCMDVAEQSLSALEILSRRHNKAIL 1204
                             |||....|...:..|...|::..|  |:.::.:.  |:..:..|..:.
 Worm   927 -----------------ALPSDFHTGWSSHGVSTRKMKFRQ--DIQKRKVQ--ELAWKLWNDHLK 970

  Fly  1205 QANGISACLTYLDFFSIVAQRAALAIAANCCLNMHPEEFHFVAESLPLLARLLSQQDKKCIESVC 1269
            :|:              ...|.||....|....:.....|..|:| ....|.:.|...:.::..|
 Worm   971 EAH--------------AKPREALVRLENAARTIESTIRHVKAQS-NFKHRNVKQPRIERVQEYC 1020

  Fly  1270 SAFCRLVESFQHDGQRLQQIASPDLLKNCQQLLLVTPAILNTGTFTAVVRMLSLMCCSCPDL--- 1331
            :|...|.||...|.:                  |.|.....:|...|:..:||:| ...||.   
 Worm  1021 AAISTLHESIVDDRR------------------LSTFEFSVSGIVPALFGLLSMM-EKFPDSFPS 1066

  Fly  1332 -----------AISLLRNDIAATL---------LYLLTGNAEPAAASATHVELISRSPSELYE-- 1374
                       |:|.|...|.|.|         ||      :....|:..::|:||......|  
 Worm  1067 RIFKEQFSKGEALSYLALKIVAVLEANEKFPQHLY------DSPGGSSFGLQLLSRRVRTKLEML 1125

  Fly  1375 ------------LTCLIGELMPRLPLDGIFAVDSLLDRPTLNTQDQVHWQWRDDRGSWHNYSTID 1427
                        |....|:::...||..:.|:.:.|.|       .|..||.|.           
 Worm  1126 PRADGKENNDENLVNKTGKIVKCEPLASVGAIRAYLHR-------MVTRQWHDR----------- 1172

  Fly  1428 SRLIEAANQSSEDEI-SLSTFGRTYTVDFHAMQQINED-----TGTTRPVQRRLNHNYVAPMSAG 1486
                |.||.....|| .|.|.|:  :::...:...:|:     .||.                  
 Worm  1173 ----ERANYRYVKEIQELKTKGK--SIELRHVSDFDENGVIYWIGTN------------------ 1213

  Fly  1487 QDLTTTSAGSAA---AGGASTSAAAAAASSNNNNNNNNNPPGNSVNLNQVKRRPSLDARIACLKE 1548
                    |.||   ...|:..|.....|      :...|.|...:|....:.|     |.|...
 Worm  1214 --------GRAAPLWTNPATVKAVKITCS------DTRQPFGKPEDLLSRDQNP-----INCHTS 1259

  Fly  1549 ERGLAADFIKHIFNV---LYEVYSSSAGPNVRYKCLRALLRMVYYATPELLRQVLKYQLVSSHI- 1609
            :     |...| |.:   |:.|.:|.:..:.|.....||...:...:.:..|    ::.|..|. 
 Worm  1260 D-----DKNAH-FTIDLGLFVVPTSYSLRHSRGYGRSALRNWMLQGSVDAKR----WENVIVHTD 1314

  Fly  1610 ---AGMLGSNDLRIV----VGALQMAEILMRQLPDVFGTHFRREGVIYQFTQLTD-PNNPICANP 1666
               .|..||.....|    ..|.:...|..........||:........:..:.| ....||.:|
 Worm  1315 DKGLGEPGSTATWHVGEKGTTAFRFFRIAQNGKNSSGQTHYLSCSGFEIYGDIVDVVTEAICEDP 1379

  Fly  1667 SPK--PLSATATPTANAGGSQSA--------------PASANSLQVNPFFMDSAPGLSSASTTPS 1715
            ..|  |...::||    |.|.||              ||..|:.:     :.|...|.:.::...
 Worm  1380 PKKDSPAGTSSTP----GSSSSAALPPLTKEQVLEMLPARENNNR-----LKSGLSLETVTSMLQ 1435

  Fly  1716 SSKHQSYSVKSFSHAMNALTAS------------------AKGTPSGALDATSSSTTAGGYNYSS 1762
            .|:|:|......|.:.:.:...                  .....||.:|.|..:..|..|.:.:
 Worm  1436 RSRHRSRGSYKISESKSKVVRGKDWRWEDQDGGEGKFGRITSPPESGWVDVTWDNGNANSYRFGA 1500

  Fly  1763 ----------------SAPSSSSGAPAAYFVTQQGDPRQYVHFQQPAVPAPPPQQELLPSGVQQQ 1811
                            |.||.:|..|.:....    .|:...|..|.....||            
 Worm  1501 NGNFDIERVTSTGHRYSTPSLASHVPTSVMEA----VRRNRAFYTPKTTGGPP------------ 1549

  Fly  1812 GQQVPQVIYQPHHQQPAHLVLASTSSGAASSSSSSSSSSSASALQHKMTDMLKRKAP---PKRKS 1873
                                   :||...:|||:.||..:||||....:  :|...|   |....
 Worm  1550 -----------------------SSSVFGTSSSAGSSRGAASALSRFAS--VKNTTPAGTPSSGG 1589

  Fly  1874 QSGGR-----------AKSRQEDAAVAPAGSGPGGAPPSSSGSAMHE------LLSRAT-----S 1916
            .|||.           ...||:.:..:.|.:|..    :|:.|..|:      ||:||.     .
 Worm  1590 SSGGAIGKKSMSTTNLVDERQKTSGPSVASTGQA----ASAESLQHQTPSLENLLARAMPHAFGR 1650

  Fly  1917 LGSGNGGRSTPNSGGGSGSSKSRFNAGNSSNAGSSKSSFLASLNPARWGRQTHQNHHHHHQQSQQ 1981
            :.........|..|..|.|:.|..:|.:|::..|..||                     .||.||
 Worm  1651 IAENQEPEDEPMGGEESDSAASMRSAASSNSQMSMGSS---------------------SQQQQQ 1694

  Fly  1982 QHHGLS-KDSG--------NSNSTGSGSGAGLAYTVSQHGAGSGAGGLNAAAVAASISKSISHAN 2037
            |...:: :||.        :.|.|.|.|...|| ...|..|.:...|...|....|..|::...:
 Worm  1695 QDSDMTPRDSAGTPSTPRDDKNQTLSVSAPDLA-AARQRQASAETDGDADADETNSEDKTVGADD 1758

  Fly  2038 LLAAANRERARQWVREQAVDFVKRYTEQEAKRSKAASE--------------------SGATQSG 2082
            .:...:.|.......|...|      :.:.:.|....|                    :|.:.|.
 Worm  1759 AMEEDDEEEETMEDEEDDDD------DDDDESSNENQEKLVELLGGERGLFDKLKEVITGESLSD 1817

  Fly  2083 SSGVGLSSTGNTPLSTAGSTNVLERLSSILFKLNGSYHDCLDALLELK--TILLESDISPFEVNH 2145
            :|.....:|.|......|      :.....||...||.|.|..|::.:  ..||:...:..|::.
 Worm  1818 ASSSAKDATTNEAQKKGG------KKPKKWFKKMSSYTDVLKGLMQNRYPVALLDPAAAGIEMDE 1876

  Fly  2146 SGLIKAMLN----YMTSETGLVERDARLRSFMHVFAGLPLEPLLQNVGQMPTIEPIAFGAFVAKL 2206
                  |::    |..||.|..:.|: :...:....|:|::.....|...   .||.:..|...:
 Worm  1877 ------MMDDDDYYDFSEDGPDDGDS-VEDEVAAHLGMPVDSFASMVAAR---TPITWRQFSELM 1931

  Fly  2207 NGCVTQLEQFPVKVHDFPAGPGGRSNQSALRFFNTHQLKCNLQR-------HPQCNNLRQWKGGT 2264
            :|...:.......|......|          :.:...:||..:.       .|..:|:.|    |
 Worm  1932 SGSNRERAAMARAVASSRGSP----------WEDDATVKCTFEALIPAFDPRPGRSNVNQ----T 1982

  Fly  2265 VKIDPLAMVQAIERYLVVRGYGGIRADSDDDSEEDMDDNVAAVVLSQASFRHKLQFTIGDHVLPY 2329
            ::         :|...||:.:|..:|.|   |:.|.||        |..|     |..|.::...
 Worm  1983 LE---------VELPTVVKDFGSTKASS---SKIDKDD--------QMRF-----FLRGPNMSGV 2022

  Fly  2330 -NMTVYQ-----AVKQFSPLVSEQPETDNESETLLGNASIWVQQHTIHYRPVEEEVTSGAAAGAA 2388
             |:|:..     ::.::..:::.......:|:.   :..||...::|.|                
 Worm  2023 DNVTIEMNDDSASLFRYMQIINNSVNWATKSDR---SRRIWEPTYSICY---------------- 2068

  Fly  2389 SSSSSCSSGVQKQQSSSSSASSCVNATSSCSSSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEG 2453
            .|:...:..|.|.....||....||   .|..:.|:.|                           
 Worm  2069 CSADQTNVEVSKIPDEESSTPCQVN---QCLETIGLLS--------------------------- 2103

  Fly  2454 IAPVVISALKPFLSSSLPADVVTVQDASLDALCMLRVIHALNRHWDHLYGCVVRQNIIPQSDFIH 2518
                                  .:|.|..:|                        .|.| :.||.
 Worm  2104 ----------------------RIQQAMPEA------------------------EITP-NVFIS 2121

  Fly  2519 PKIMAKANRQLQDPLVIMTGNLPQWLPQIGMACPFLFPFETRHLLFYATSFD-----------RD 2572
            .|:..|..:.|.|.||:...:||:|..::....|.||..|||::...||:|.           ||
 Worm  2122 DKLTLKVTQVLSDALVVAARSLPEWCSRLVYKYPCLFTVETRNMYMQATAFGVSRTIVWLQQRRD 2186

  Fly  2573 RALQRLLDTTP--DLNAAESSERV----APRLDRRKRAISRTE--ILKQAEHILQDFGHSKALLE 2629
            .|::|...:..  :.:||...:|.    ..||...:..::|.|  :|.||..:::.....||:||
 Worm  2187 AAVERARGSAQAGNSSAARQHDRYHEYRVGRLRHERVKVTRAEETLLDQAIRLMKFHADRKAVLE 2251

  Fly  2630 IQYENEVGTGLGPTLEFYALVSAELQRTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEA 2694
            |:|.||.||||||||||||||:|||||..|.||            :.|                 
 Worm  2252 IEYTNEEGTGLGPTLEFYALVAAELQRKSLALW------------VCD----------------- 2287

  Fly  2695 TTTDQNTPAVAGASLVSSSTTTTTTTAQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANEN 2759
               |.:|.|                          ..|.....:..|.|::|:.:          
 Worm  2288 ---DDDTHA--------------------------SKSGEEREVDLGEGKKPIGY---------- 2313

  Fly  2760 ALNMVIAQQFSDTNSANPAAIDNPSSTTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLP 2824
                                                                 ||..|.||||.|
 Worm  2314 -----------------------------------------------------YVRRVGGLFPAP 2325

  Fly  2825 LGKSSKLPQMTKAKAKFKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEE----------HSI-G 2878
            |...:  .:..:|...|:.||.|:||.::|.|::|||.|.||.:.||..:          |.| .
 Worm  2326 LPPGT--DETKRAADMFRVLGVFLAKVLLDGRLVDLPLSRPFLKLLVHPQIGDDARGPNLHKILS 2388

  Fly  2879 LADLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDAMEKTEKIEQLDL----DGCPIADLGLDFV 2939
            |.|...|.|...:.|..|:.|.:::..|.:|.:||:..|..||.:|.|    ..|.:.||.|:|.
 Worm  2389 LDDFEEVNPVKGSFLKELRALAQRKRLIENDTSIDSNSKRRKIAELKLHIKGSTCRVEDLALNFT 2453

  Fly  2940 L--PG----HANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFEALREGFDSVFPIQRL 2998
            :  |.    :|.:||..||.|..||:.|:.||:.....::|..|:..|..|.|:|||.|||::.|
 Worm  2454 VNPPSKVFQYAEMELVDGGSDIDVTIDNVEQYVEKCEEFYLNTGIAYQMRAFRDGFDRVFPLRTL 2518

  Fly  2999 RMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFHQDSQAIQYLYEILASYNRDEQRAFL 3063
            |.:.|||::.:..|    :|...|....:........|:.::|.......:::.:....|::.||
 Worm  2519 RAYSPEEVQRLLSG----EQCPEWSRDDILNYTEPKLGYTRESPGFLRFVDVMEALTAQERKNFL 2579

  Fly  3064 QFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSVMTCVNYLKLPDYSSREVMRQKLKV 3128
            ||.||...||.||...|.|.||||||.    ::.:...|||.|||:|||||:|||..::|::|..
 Worm  2580 QFATGCSSLPPGGLANLHPRLTIVRKV----ESGDGSYPSVNTCVHYLKLPEYSSSAILRERLLT 2640

  Fly  3129 AANEGSMSFHLS 3140
            |.||  ..|||:
 Worm  2641 AINE--KGFHLN 2650

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ctripNP_001189170.1 Extensin_2 <688..731 CDD:252669
WWE 1409..1481 CDD:128922 15/77 (19%)
FAM199X <1985..2074 CDD:292442 18/97 (19%)
HECTc <2818..3138 CDD:294058 117/340 (34%)
hecd-1NP_001368365.1 Ank_2 345..436 CDD:403870
ANK repeat 345..372 CDD:293786
ANK repeat 374..403 CDD:293786
PTZ00322 383..>497 CDD:140343
ANK repeat 405..436 CDD:293786
F5_F8_type_C 1243..1365 CDD:419973 24/136 (18%)
MIB_HERC2 1452..1509 CDD:399589 6/56 (11%)
HECTc 2221..2648 CDD:238033 163/559 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10145at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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