DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and herc-1

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_490834.1	Gene:	herc-1 / 171700	WormBaseID:	WBGene00021685	Length:	1019	Species:	Caenorhabditis elegans

Alignment Length:	959	Identity:	189/959 - (19%)
Similarity:	333/959 - (34%)	Gaps:	253/959 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  2259 QWKGGTVKIDPLAMVQAIERYLVVRGYGGIRADSDDDSEEDMDD-----NVAAVVLSQASFRHKL 2318
            |...|.:.||.|....:::....:.|.|.:.|...|:....:..     :..:..|.|..|..|:
Worm   216 QNNSGELGIDDLRPQTSVQHVHQMDGLGVVEAACGDNHTVLLTHCGRTFSFGSDALGQCGFGKKV 280

  Fly  2319 Q---------FTIGDHV----------------LPYNMTVYQAVKQFSPLVSEQPETDNESETLL 2358
            :         ..||.||                .||...:                   .|...|
Worm   281 EKRTNPTAVSDLIGSHVTRIAAGACHTIAICKGAPYPFGL-------------------NSSGQL 326

  Fly  2359 GNASIWVQQHTIHYRPVEE-EVTSGAAAGAASSSSSCSSGVQKQQSSSSSASSCVNATSSCSSSS 2422
            ||..|..|...   |..:| :..:|..||...:....|||..:|...         ...||....
Worm   327 GNGKIMTQSTP---RKTDELDHVTGVFAGYHQTFFVRSSGTIEQNEI---------VGPSCPMQY 379

  Fly  2423 GVASGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVISALKPFLSS------------------- 2468
            .:        |..|:|..|       |..||.|..|:|.::...||
Worm   380 PI--------KLDHESLKK-------LLDEGDALEVMSLIESVFSSLASMNMSFLYKDERRYNVG 429

  Fly  2469 -----SLPADVVTVQDASL--DALCMLR-----VIHALN---RHW-DHLYG--CVVRQNIIPQSD 2515
                 |...|:..|.:|.:  |...|.|     ::.:|.   :.| ::|.|  |:....::|...
Worm   430 FCFERSHGIDMDQVMEAFMLFDEYPMKRQYMELIVDSLKIAFQEWSENLKGIECLRVLLMLPWLP 494

  Fly  2516 FIHPKIMAKANRQLQDPLV----IMTGN----LPQWLPQIGMACPFLFPFETRHLLFYATSFDRD 2572
            .....:..:..:.:..|.|    ::||:    |.:|..|:          .|||.....|.|  .
Worm   495 IFTENVNVQTIKNVHTPFVDAMCLITGDLRAALEKWWTQL----------STRHFRRMVTVF--K 547

  Fly  2573 RALQRLLDTTPDLNAAESSERVAPRLDRRK--RAISRTEILKQAEHILQDFGHSKALLEIQYENE 2635
            .|::.:|           ..:..|| |..|  ..:.:..::.:..||:.        ||..|.:|
Worm   548 TAIKAML-----------KAKKGPR-DCHKFILIMQKLSLINKTYHIIP--------LETFYIDE 592

  Fly  2636 VGTGLGPTLEF-YALVSAELQRTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQ 2699
            :.|.:...||: ..|...:..:|:|..|. ...:..|.|       |...::.:|..|..|...|
Worm   593 LNTSVDLKLEYVLELTRQDPNKTELDYWT-HFPFLLNGV-------AKGELIFVEAWLMQTLRRQ 649

  Fly  2700 NTPAVAGASLVSSSTTTTTTTAQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMV 2764
                   :||.:::..|..     .:.|....:.|...:.|....|       .||.:|:.|...
Worm   650 -------SSLFNTAHGTII-----FELPHLELTVRREFIVSDTMNQ-------MAGLSESDLQKP 695

  Fly  2765 IAQQFSDTNSANPAAIDNPSSTTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLF----PLPL 2825
            :....:..::.:...:...........::|.:                     :|:|    ...|
Worm   696 LKVNIAGEDADDAGGVRKEFFILVMRKILQSD---------------------YGMFSEDEESHL 739

  Fly  2826 GKSSKLPQMTKAKAKFKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQ 2890
            ...|.||.....:.:|..||:.:..::.:..::..||.|..|::|:.....  |.||..::|...
Worm   740 VWFSGLPSEFCDREQFHQLGRLVGLSIYNHSIVPFPFPLALYKYLLDTPPD--LEDLCELSPSEG 802

  Fly  2891 NTLVRLQDLVRQREYILSDPNIDAMEKTEKIEQLDLDGCPIADLGLDFVLPGHAN-IELCRGGRD 2954
            ..|          :.:||      .|:.:..:...|:.|      :.|.:.|..: .||..||.:
Worm   803 KGL----------KMLLS------YEEDDVEDVFGLNFC------ISFNILGETHTTELLSGGTE 845

  Fly  2955 TPVTVHNLHQYISLVTYWFLIEG----VQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGS 3015
            .|||..|..:|:.|..:..|..|    :.:|....|:||......:.||.|.|.||:.:..|:.:
Worm   846 KPVTNANRDEYVRLYVHHRLELGYNGEIAQQALLFRKGFSESLHSRTLRFFQPCELKEMIVGNEN 910

  Fly  3016 EQQHSRWEIKMLQESCRTDHGFHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKAL 3080
            ...:...:|.|.:....:.|      ..||..::...:...||:|.||||:|||.|:|..|::.|
Worm   911 YDWNEFRDILMYRGEYSSSH------PTIQAFWKAFFALTDDERRKFLQFLTGSTRIPVSGWEEL 969

  Fly  3081 TPPLTIVRKTLDENQNPNDYLPSVMTCVNYLKLPDYSSREVMRQKLKVA 3129
            .   ..::.:..|:      ||...||.|.|.||:.:....:.::|:::
Worm   970 H---AAIQPSAPES------LPVAHTCFNLLDLPNIADDVELLRRLRIS 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	78/321 (24%)
herc-1	NP_490834.1	ATS1	2..359	CDD:227511	30/164 (18%)
herc-1	NP_490834.1	HECTc	667..1016	CDD:238033	86/410 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900