DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ctrip and Trip12

DIOPT Version :9

Sequence 1:NP_001189170.1 Gene:ctrip / 40596 FlyBaseID:FBgn0260794 Length:3140 Species:Drosophila melanogaster
Sequence 2:XP_011236956.1 Gene:Trip12 / 14897 MGIID:1309481 Length:2074 Species:Mus musculus


Alignment Length:2701 Identity:1023/2701 - (37%)
Similarity:1391/2701 - (51%) Gaps:695/2701 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   499 GGERQQPQRATNNAK---------------KTKNNTPAVAAASTIKA-----TTTATTSSGYQQR 543
            ||..::.||.|..|:               |.|...|..:..|..||     .||:..|.|:..:
Mouse    10 GGSLRRSQRNTAGAQPQDDSIGGRSHLGQAKRKGYIPPESRKSNFKAPKVQSNTTSELSRGHLSK 74

  Fly   544 AAPHGQGAAPGAGGGGPRATRSSNSNSSNNVVDYSIMPHLTTVATTTPHALTPQQHQQQRQPPQP 608
                                ||.:|:|:      .|:|.     ...|......:.|:..|.|:.
Mouse    75 --------------------RSCSSSSA------VIVPQ-----PEDPDRANTSERQKTGQVPKK 108

  Fly   609 PSHQ------QQQVHQQQQPPQLLPTHQFAHLSSFVTPTAAAAAAAAAAHYPPASAAAAYFAQQQ 667
            .:.:      ....::...|........|.|:.||           :..:.|.:.:         
Mouse   109 DNSRGVKRSASPDYNRTNSPSSAKKPRAFQHIESF-----------SETNKPHSKS--------- 153

  Fly   668 HHQHQHQHQQQHVQQAQAPQPHYYHSSVAVLHQPPPHHFTSTGAGPPPALFQQQAPPQLTRYTPA 732
              :.:|..|:|.::.||.|.....|:.            .|..||......:::......:....
Mouse   154 --KKRHLDQEQQLKSAQLPSTSKAHTR------------KSVAAGSSRNQKRKRTESSCVKSGSG 204

  Fly   733 TATTAATFVPPQQQQVVYNPQQQQHSSLRRSSRGKTGSCVSSAAAAQQQQHHQQQQHSSAAAAVQ 797
            :.:|.|              :::....::.:|:..|.:....:..............|||.|:  
Mouse   205 SESTGA--------------EERSAKPIKLASKSATSAKAGCSTITDSSSAASTSSSSSAIAS-- 253

  Fly   798 QQLLPPPGTYQYQQVGGNTVVVAVRHQQQLQQQQQQQQQLALHHQHQQQQHQQQQQQHQQQQH-- 860
                           ..:||....|.:|...|.:.::.:.|.....::...:::|.:......  
Mouse   254 ---------------ASSTVPAGARVKQGKDQNKARRSRSASSPSPRRSSREKEQSKTGGSSKFD 303

  Fly   861 ---QQQQRATLVQPGFLFSYRSNQPQQQQQPAQQIHQGPKVTHSSAASDALTYSLMAQQPPSGPP 922
               :...:.:|  |....|...:...:..:|      ||....:..||...:....::.||:..|
Mouse   304 WAARFSPKVSL--PKTKLSLPGSSKSETSKP------GPSGLQAKLASLRKSTKKRSESPPAELP 360

  Fly   923 --HAGGQQITPGANSANLSIVAAALSAARDVGGGSDGGGSAGGATPATGASASSVGNTSAVGASS 985
              ....:|.|.|         :.|.::.|..|.|..|...|    ......|....|...|.:|:
Mouse   361 SLRRSTRQKTTG---------SCASTSRRGSGLGKRGAAEA----RRQEKMADPESNQETVNSSA 412

  Fly   986 SSNSSAGQAASSNSNNVTATGSGSAPGGGPTSTGTTSGTQHGSGSGAAAAVDSESDDSEVGRLQA 1050
            :....|.|.|:::|:...|.|.            ||||             :|||||||:|||||
Mouse   413 ARTDEAPQGAAASSSVAGAVGM------------TTSG-------------ESESDDSEMGRLQA 452

  Fly  1051 LLEARGLPPHLFGALGPRVTHILHRTIGNSSSSKANQLLQGLQSHDESQQLQAAIEMCQMLVMGN 1115
            |||||||||||||.||||::.:.|||||:.:||||.|||||||:.||||||||.|||||:|||||
Mouse   453 LLEARGLPPHLFGPLGPRMSQLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGN 517

  Fly  1116 EDTLAGFPIKQVVPALIQLLRMEHNFDIMNNACRALAYMLEALPRSSGTVVEAVPVFLEKLQVIQ 1180
            |:||.|||:|.||||||.||:|||||||||:|||||.||:|||||||..||:|:|||||||||||
Mouse   518 EETLGGFPVKSVVPALITLLQMEHNFDIMNHACRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQ 582

  Fly  1181 CMDVAEQSLSALEILSRRHNKAILQANGISACLTYLDFFSIVAQRAALAIAANCCLNMHPEEFHF 1245
            |:|||||:|:|||:|||||:||||||.|::.||.||:||||.|||.|||||||||.::.|:||||
Mouse   583 CIDVAEQALTALEMLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHF 647

  Fly  1246 VAESLPLLARLLSQQDKKCIESVCSAFCRLVESFQHDGQRLQQIASPDLLKNCQQLLLVTPAILN 1310
            ||:|||||.:.|:.||||.:||.|..|.|||::|||:...|||:||.|||.|.||||:|||.||:
Mouse   648 VADSLPLLTQRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTPPILS 712

  Fly  1311 TGTFTAVVRMLSLMCCSCPDLAISLLR---NDIAATLLYLLTGNAEPAAASATHVELISRSPSEL 1372
            :|.|..||||.||||.:||.||:.|::   .|||.||.:||.|.:.  .:....::|:.|||.||
Mouse   713 SGMFIMVVRMFSLMCSNCPTLAVQLMKQSFTDIAETLHFLLCGASN--GSCQEQIDLVPRSPQEL 775

  Fly  1373 YELTCLIGELMPRLPLDGIFAVDSLLDRPTLNTQDQVHWQWRDDRGSWHNYSTIDSRLIE-AANQ 1436
            ||||.||.||||.||.:||||||::|.:......|...||||||||.||.|:.||||:|| ||:|
Mouse   776 YELTSLICELMPCLPKEGIFAVDTMLKKGNAQNTDGAIWQWRDDRGLWHPYNRIDSRIIEVAAHQ 840

  Fly  1437 SSEDEISLSTFGRTYTVDFHAMQQINEDTGTTRPVQRRLNHNYVAPMSAGQDLTTTSAGSAAAGG 1501
            ..||||||||.||.||:||::||||||||||.|.:||:.|     |::                 
Mouse   841 VGEDEISLSTLGRVYTIDFNSMQQINEDTGTARAIQRKPN-----PLA----------------- 883

  Fly  1502 ASTSAAAAAASSNNNNNNNNNPPGNSVNLNQVKRRPSLDARIACLKEERGLAADFIKHIFNVLYE 1566
                              |:|..|.|    ::|:.   |||...:||:..||..|||.:|.||||
Mouse   884 ------------------NSNTSGYS----ELKKD---DARAQLMKEDPELAKSFIKTLFGVLYE 923

  Fly  1567 VYSSSAGPNVRYKCLRALLRMVYYATPELLRQVLKYQLVSSHIAGMLGSNDLRIVVGALQMAEIL 1631
            ||||||||.||:|||||:||::|:|..|||:.|||...||||||.||.|.||:||||||||||||
Mouse   924 VYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDLKIVVGALQMAEIL 988

  Fly  1632 MRQLPDVFGTHFRREGVIYQFTQLTDPNNPICANPSPKPLSATATPTANAGGSQSAPASANSLQV 1696
            |::|||:|..:||||||::|...|.:..:.:           |:.|.|...||.|.         
Mouse   989 MQKLPDIFSVYFRREGVMHQVKHLAESESLL-----------TSPPKACTNGSGSL--------- 1033

  Fly  1697 NPFFMDSAPGLSSASTTPSSSKHQSYSVKSFSHAMNALTASAKGTPSGALDATSSSTTAGGYNYS 1761
                         .||||:||                      ||.:.|.:|             
Mouse  1034 -------------GSTTPASS----------------------GTATAATNA------------- 1050

  Fly  1762 SSAPSSSSGAPAAYFVTQQGDPRQYVHFQQPAVPAPPPQQELLPSGVQQQGQQVPQVIYQPHHQQ 1826
                |:..|:|:..            |.:..::       :|.|.|                   
Mouse  1051 ----SADLGSPSLQ------------HSRDDSL-------DLSPQG------------------- 1073

  Fly  1827 PAHLVLASTSSGAASSSSSSSSSSSASALQHKMTDMLKRKAPPKRKSQSGGRAKSRQEDAAVAPA 1891
                                           :::|:||||..|||    |.|.            
Mouse  1074 -------------------------------RLSDVLKRKRLPKR----GPRR------------ 1091

  Fly  1892 GSGPGGAPPSSSGSAMHELLSRATSLGSGNGGRSTPNSGGGSGSSKSRFNAGNSSNAGSSKSSFL 1956
               |..:||.......::..|..|:                                .|.|||||
Mouse  1092 ---PKYSPPRDDDKVDNQAKSPTTT--------------------------------QSPKSSFL 1121

  Fly  1957 ASLNPARWGRQTHQNHHHHHQQSQQQHHGLSKDSGNSNSTGSGSGAGLAYTVSQHGAGSGAGGLN 2021
            |||||..|||.:.|:                    |||:......||::             ||.
Mouse  1122 ASLNPKTWGRLSAQS--------------------NSNNIEPARTAGVS-------------GLA 1153

  Fly  2022 AAAVAASISKSISHANLLAAANRERARQWVREQAVDFVKRYTEQEAKRSKAASESGATQSGSSGV 2086
            .||...:||.           |||:.:.|::|||..||:||...|                    
Mouse  1154 RAASKDTISN-----------NREKIKGWIKEQAHKFVERYFSSE-------------------- 1187

  Fly  2087 GLSSTGNTPLSTAGSTNVLERLSSILFKLNGSYHDCLDALLELKTILLESDISPFEVNHSGLIKA 2151
              :..|:.|     :.|||:||.:...:||.......:.|:|:::|:.|||:|.||:.|||.:|.
Mouse  1188 --NMDGSNP-----ALNVLQRLCAATEQLNLQVDGGAECLVEIRSIVSESDVSSFEIQHSGFVKQ 1245

  Fly  2152 MLNYMTS--ETGLVERDARLRSFMHVFAGLPL---EPL--LQNVGQMPTIEPIAFGAFVAKLNGC 2209
            :|.|:||  |...|.|:.||:.|:|||...||   ||:  ::.||..|.:      |.|.|:|.|
Mouse  1246 LLLYLTSKNEKDAVGREIRLKRFLHVFFSSPLPGEEPVGRVEPVGHAPLL------ALVHKMNNC 1304

  Fly  2210 VTQLEQFPVKVHDFPAGPG-------GRSNQSALRFFNTHQLKCNLQRHPQCNNLRQWKGGTVKI 2267
            ::|:|||||||||||:|.|       .|.:| ||:|||||||||.|||||.|.|::|||||.|||
Mouse  1305 LSQMEQFPVKVHDFPSGNGAGGSFSLNRGSQ-ALKFFNTHQLKCQLQRHPDCANVKQWKGGPVKI 1368

  Fly  2268 DPLAMVQAIERYLVVRG---YGGIR---ADSDDD-SEEDMDDNVAAVVLSQASFRHKLQFTIGDH 2325
            ||||:||||||||||||   ||.:|   .||||| |:|::|:::||..|:..:.||:|||.||:|
Mouse  1369 DPLALVQAIERYLVVRGIFRYGRVREDDEDSDDDGSDEEIDESLAAQFLNSGNVRHRLQFYIGEH 1433

  Fly  2326 VLPYNMTVYQAVKQFSPLVSEQPETDNESETLLGNASIWVQQHTIHYRPVEEEVTSGAAAGAASS 2390
            :|||||||||||:|||....::.|:.::....||.|.||.:.|||.|:||.|:         ..|
Mouse  1434 LLPYNMTVYQAVRQFSVQAEDERESTDDESNPLGRAGIWTKTHTIWYKPVRED---------EES 1489

  Fly  2391 SSSCSSGVQKQQSSSSSASSCVNATSSCSSSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEGIA 2455
            :..|..|.:.:..::.:.:|..||                             :|..||||:|:.
Mouse  1490 TKDCVGGKRGRAQTAPTKTSPRNA-----------------------------KKHDELWHDGVC 1525

  Fly  2456 PVVISALKPFLSSSLPADVVTVQDASLDALCMLRVIHALNRHWDHLYGCVVRQNIIPQSDFIHPK 2520
            |.|.:.|:.:|..: |.:.:|.:|.|||.:.:|||:||::|:|.:||...:.:.|||.|:||:.|
Mouse  1526 PSVANPLEVYLIPT-PPENITFEDPSLDVILLLRVLHAISRYWYYLYDNAMCKEIIPTSEFINSK 1589

  Fly  2521 IMAKANRQLQDPLVIMTGNLPQWLPQIGMACPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDL 2585
            :.|||||||||||||||||:|.||.::|..|||.|||:||.:|||.|:||||||:||||||.|::
Mouse  1590 LTAKANRQLQDPLVIMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEI 1654

  Fly  2586 NAAESSE-RVAPRLDRRKRAISRTEILKQAEHILQDFGHSKALLEIQYENEVGTGLGPTLEFYAL 2649
            |.::|.: ||||||||:||.::|.|:|||||.::||.|.|:|:||||||||||||||||||||||
Mouse  1655 NQSDSQDSRVAPRLDRKKRTVNREELLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTLEFYAL 1719

  Fly  2650 VSAELQRTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSST 2714
            ||.||||.||.||.|.:      ||:                                       
Mouse  1720 VSQELQRADLCLWRGEE------VTL--------------------------------------- 1739

  Fly  2715 TTTTTTAQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAA 2779
                                                |:..|:.|.                    
Mouse  1740 ------------------------------------SNPKGSQEG-------------------- 1748

  Fly  2780 IDNPSSTTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKAKFKFL 2844
                                           |.|:..:.|||.||.|:::|...:.|.|.||:||
Mouse  1749 -------------------------------TKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRFL 1782

  Fly  2845 GKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSD 2909
            ||.||||:||.|::|||..||||:|::.:|.|:...||..:.|.|..::..|:|:|||::.:..|
Mouse  1783 GKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQD 1847

  Fly  2910 PNIDAMEKTEKIEQLDLDGCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFL 2974
            .:.........:|.|.::||.:.||||||.|||..||||.:||:|.|||:|||.:|:.||.:|.|
Mouse  1848 KSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWAL 1912

  Fly  2975 IEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFHQ 3039
            .|||.:||::.|:||:||||:..|:.||||||:.:.|||.::    .|:.|.|.|.||.|||:..
Mouse  1913 NEGVCRQFDSFRDGFESVFPLCHLQYFYPEELDQLLCGSKAD----TWDAKTLMECCRPDHGYTH 1973

  Fly  3040 DSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSV 3104
            ||:|:::|:|||:|::.::||.||||||||||||.|||::|.|||||||||.:..:||:|:||||
Mouse  1974 DSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSV 2038

  Fly  3105 MTCVNYLKLPDYSSREVMRQKLKVAANEGSMSFHLS 3140
            ||||||||||||||.::||.||.:||.||..|||||
Mouse  2039 MTCVNYLKLPDYSSIDIMRDKLLIAAREGQQSFHLS 2074

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ctripNP_001189170.1 Extensin_2 <688..731 CDD:252669 4/42 (10%)
WWE 1409..1481 CDD:128922 48/72 (67%)
FAM199X <1985..2074 CDD:292442 23/88 (26%)
HECTc <2818..3138 CDD:294058 169/319 (53%)
Trip12XP_011236956.1 SRP1 489..>714 CDD:227396 164/224 (73%)
WWE 814..876 CDD:397111 45/61 (74%)
HECTc 1672..2072 CDD:238033 223/535 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 562 1.000 Domainoid score I238
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1702 1.000 Inparanoid score I75
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0004709
OrthoInspector 1 1.000 - - oto94944
orthoMCL 1 0.900 - - OOG6_102181
Panther 1 1.100 - - LDO PTHR45670
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3704
SonicParanoid 1 1.000 - - X3310
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.940

Return to query results.
Submit another query.