|
Fly 499 GGERQQPQRATNNAK---------------KTKNNTPAVAAASTIKA-----TTTATTSSGYQQR 543
||..::.||.|..|: |.|...|..:..|..|| .||:..|.|:..:
Mouse 10 GGSLRRSQRNTAGAQPQDDSIGGRSHLGQAKRKGYIPPESRKSNFKAPKVQSNTTSELSRGHLSK 74
Fly 544 AAPHGQGAAPGAGGGGPRATRSSNSNSSNNVVDYSIMPHLTTVATTTPHALTPQQHQQQRQPPQP 608
||.:|:|: .|:|. ...|......:.|:..|.|:.
Mouse 75 --------------------RSCSSSSA------VIVPQ-----PEDPDRANTSERQKTGQVPKK 108
Fly 609 PSHQ------QQQVHQQQQPPQLLPTHQFAHLSSFVTPTAAAAAAAAAAHYPPASAAAAYFAQQQ 667
.:.: ....::...|........|.|:.|| :..:.|.:.:
Mouse 109 DNSRGVKRSASPDYNRTNSPSSAKKPRAFQHIESF-----------SETNKPHSKS--------- 153
Fly 668 HHQHQHQHQQQHVQQAQAPQPHYYHSSVAVLHQPPPHHFTSTGAGPPPALFQQQAPPQLTRYTPA 732
:.:|..|:|.::.||.|.....|:. .|..||......:::......:....
Mouse 154 --KKRHLDQEQQLKSAQLPSTSKAHTR------------KSVAAGSSRNQKRKRTESSCVKSGSG 204
Fly 733 TATTAATFVPPQQQQVVYNPQQQQHSSLRRSSRGKTGSCVSSAAAAQQQQHHQQQQHSSAAAAVQ 797
:.:|.| :::....::.:|:..|.:....:..............|||.|:
Mouse 205 SESTGA--------------EERSAKPIKLASKSATSAKAGCSTITDSSSAASTSSSSSAIAS-- 253
Fly 798 QQLLPPPGTYQYQQVGGNTVVVAVRHQQQLQQQQQQQQQLALHHQHQQQQHQQQQQQHQQQQH-- 860
..:||....|.:|...|.:.::.:.|.....::...:::|.:......
Mouse 254 ---------------ASSTVPAGARVKQGKDQNKARRSRSASSPSPRRSSREKEQSKTGGSSKFD 303
Fly 861 ---QQQQRATLVQPGFLFSYRSNQPQQQQQPAQQIHQGPKVTHSSAASDALTYSLMAQQPPSGPP 922
:...:.:| |....|...:...:..:| ||....:..||...:....::.||:..|
Mouse 304 WAARFSPKVSL--PKTKLSLPGSSKSETSKP------GPSGLQAKLASLRKSTKKRSESPPAELP 360
Fly 923 --HAGGQQITPGANSANLSIVAAALSAARDVGGGSDGGGSAGGATPATGASASSVGNTSAVGASS 985
....:|.|.| :.|.::.|..|.|..|...| ......|....|...|.:|:
Mouse 361 SLRRSTRQKTTG---------SCASTSRRGSGLGKRGAAEA----RRQEKMADPESNQETVNSSA 412
Fly 986 SSNSSAGQAASSNSNNVTATGSGSAPGGGPTSTGTTSGTQHGSGSGAAAAVDSESDDSEVGRLQA 1050
:....|.|.|:::|:...|.|. |||| :|||||||:|||||
Mouse 413 ARTDEAPQGAAASSSVAGAVGM------------TTSG-------------ESESDDSEMGRLQA 452
Fly 1051 LLEARGLPPHLFGALGPRVTHILHRTIGNSSSSKANQLLQGLQSHDESQQLQAAIEMCQMLVMGN 1115
|||||||||||||.||||::.:.|||||:.:||||.|||||||:.||||||||.|||||:|||||
Mouse 453 LLEARGLPPHLFGPLGPRMSQLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGN 517
Fly 1116 EDTLAGFPIKQVVPALIQLLRMEHNFDIMNNACRALAYMLEALPRSSGTVVEAVPVFLEKLQVIQ 1180
|:||.|||:|.||||||.||:|||||||||:|||||.||:|||||||..||:|:|||||||||||
Mouse 518 EETLGGFPVKSVVPALITLLQMEHNFDIMNHACRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQ 582
Fly 1181 CMDVAEQSLSALEILSRRHNKAILQANGISACLTYLDFFSIVAQRAALAIAANCCLNMHPEEFHF 1245
|:|||||:|:|||:|||||:||||||.|::.||.||:||||.|||.|||||||||.::.|:||||
Mouse 583 CIDVAEQALTALEMLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHF 647
Fly 1246 VAESLPLLARLLSQQDKKCIESVCSAFCRLVESFQHDGQRLQQIASPDLLKNCQQLLLVTPAILN 1310
||:|||||.:.|:.||||.:||.|..|.|||::|||:...|||:||.|||.|.||||:|||.||:
Mouse 648 VADSLPLLTQRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTPPILS 712
Fly 1311 TGTFTAVVRMLSLMCCSCPDLAISLLR---NDIAATLLYLLTGNAEPAAASATHVELISRSPSEL 1372
:|.|..||||.||||.:||.||:.|:: .|||.||.:||.|.:. .:....::|:.|||.||
Mouse 713 SGMFIMVVRMFSLMCSNCPTLAVQLMKQSFTDIAETLHFLLCGASN--GSCQEQIDLVPRSPQEL 775
Fly 1373 YELTCLIGELMPRLPLDGIFAVDSLLDRPTLNTQDQVHWQWRDDRGSWHNYSTIDSRLIE-AANQ 1436
||||.||.||||.||.:||||||::|.:......|...||||||||.||.|:.||||:|| ||:|
Mouse 776 YELTSLICELMPCLPKEGIFAVDTMLKKGNAQNTDGAIWQWRDDRGLWHPYNRIDSRIIEVAAHQ 840
Fly 1437 SSEDEISLSTFGRTYTVDFHAMQQINEDTGTTRPVQRRLNHNYVAPMSAGQDLTTTSAGSAAAGG 1501
..||||||||.||.||:||::||||||||||.|.:||:.| |::
Mouse 841 VGEDEISLSTLGRVYTIDFNSMQQINEDTGTARAIQRKPN-----PLA----------------- 883
Fly 1502 ASTSAAAAAASSNNNNNNNNNPPGNSVNLNQVKRRPSLDARIACLKEERGLAADFIKHIFNVLYE 1566
|:|..|.| ::|:. |||...:||:..||..|||.:|.||||
Mouse 884 ------------------NSNTSGYS----ELKKD---DARAQLMKEDPELAKSFIKTLFGVLYE 923
Fly 1567 VYSSSAGPNVRYKCLRALLRMVYYATPELLRQVLKYQLVSSHIAGMLGSNDLRIVVGALQMAEIL 1631
||||||||.||:|||||:||::|:|..|||:.|||...||||||.||.|.||:||||||||||||
Mouse 924 VYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDLKIVVGALQMAEIL 988
Fly 1632 MRQLPDVFGTHFRREGVIYQFTQLTDPNNPICANPSPKPLSATATPTANAGGSQSAPASANSLQV 1696
|::|||:|..:||||||::|...|.:..:.: |:.|.|...||.|.
Mouse 989 MQKLPDIFSVYFRREGVMHQVKHLAESESLL-----------TSPPKACTNGSGSL--------- 1033
Fly 1697 NPFFMDSAPGLSSASTTPSSSKHQSYSVKSFSHAMNALTASAKGTPSGALDATSSSTTAGGYNYS 1761
.||||:|| ||.:.|.:|
Mouse 1034 -------------GSTTPASS----------------------GTATAATNA------------- 1050
Fly 1762 SSAPSSSSGAPAAYFVTQQGDPRQYVHFQQPAVPAPPPQQELLPSGVQQQGQQVPQVIYQPHHQQ 1826
|:..|:|:.. |.:..:: :|.|.|
Mouse 1051 ----SADLGSPSLQ------------HSRDDSL-------DLSPQG------------------- 1073
Fly 1827 PAHLVLASTSSGAASSSSSSSSSSSASALQHKMTDMLKRKAPPKRKSQSGGRAKSRQEDAAVAPA 1891
:::|:||||..||| |.|.
Mouse 1074 -------------------------------RLSDVLKRKRLPKR----GPRR------------ 1091
Fly 1892 GSGPGGAPPSSSGSAMHELLSRATSLGSGNGGRSTPNSGGGSGSSKSRFNAGNSSNAGSSKSSFL 1956
|..:||.......::..|..|: .|.|||||
Mouse 1092 ---PKYSPPRDDDKVDNQAKSPTTT--------------------------------QSPKSSFL 1121
Fly 1957 ASLNPARWGRQTHQNHHHHHQQSQQQHHGLSKDSGNSNSTGSGSGAGLAYTVSQHGAGSGAGGLN 2021
|||||..|||.:.|: |||:......||:: ||.
Mouse 1122 ASLNPKTWGRLSAQS--------------------NSNNIEPARTAGVS-------------GLA 1153
Fly 2022 AAAVAASISKSISHANLLAAANRERARQWVREQAVDFVKRYTEQEAKRSKAASESGATQSGSSGV 2086
.||...:||. |||:.:.|::|||..||:||...|
Mouse 1154 RAASKDTISN-----------NREKIKGWIKEQAHKFVERYFSSE-------------------- 1187
Fly 2087 GLSSTGNTPLSTAGSTNVLERLSSILFKLNGSYHDCLDALLELKTILLESDISPFEVNHSGLIKA 2151
:..|:.| :.|||:||.:...:||.......:.|:|:::|:.|||:|.||:.|||.:|.
Mouse 1188 --NMDGSNP-----ALNVLQRLCAATEQLNLQVDGGAECLVEIRSIVSESDVSSFEIQHSGFVKQ 1245
Fly 2152 MLNYMTS--ETGLVERDARLRSFMHVFAGLPL---EPL--LQNVGQMPTIEPIAFGAFVAKLNGC 2209
:|.|:|| |...|.|:.||:.|:|||...|| ||: ::.||..|.: |.|.|:|.|
Mouse 1246 LLLYLTSKNEKDAVGREIRLKRFLHVFFSSPLPGEEPVGRVEPVGHAPLL------ALVHKMNNC 1304
Fly 2210 VTQLEQFPVKVHDFPAGPG-------GRSNQSALRFFNTHQLKCNLQRHPQCNNLRQWKGGTVKI 2267
::|:|||||||||||:|.| .|.:| ||:|||||||||.|||||.|.|::|||||.|||
Mouse 1305 LSQMEQFPVKVHDFPSGNGAGGSFSLNRGSQ-ALKFFNTHQLKCQLQRHPDCANVKQWKGGPVKI 1368
Fly 2268 DPLAMVQAIERYLVVRG---YGGIR---ADSDDD-SEEDMDDNVAAVVLSQASFRHKLQFTIGDH 2325
||||:|||||||||||| ||.:| .||||| |:|::|:::||..|:..:.||:|||.||:|
Mouse 1369 DPLALVQAIERYLVVRGIFRYGRVREDDEDSDDDGSDEEIDESLAAQFLNSGNVRHRLQFYIGEH 1433
Fly 2326 VLPYNMTVYQAVKQFSPLVSEQPETDNESETLLGNASIWVQQHTIHYRPVEEEVTSGAAAGAASS 2390
:|||||||||||:|||....::.|:.::....||.|.||.:.|||.|:||.|: ..|
Mouse 1434 LLPYNMTVYQAVRQFSVQAEDERESTDDESNPLGRAGIWTKTHTIWYKPVRED---------EES 1489
Fly 2391 SSSCSSGVQKQQSSSSSASSCVNATSSCSSSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEGIA 2455
:..|..|.:.:..::.:.:|..|| :|..||||:|:.
Mouse 1490 TKDCVGGKRGRAQTAPTKTSPRNA-----------------------------KKHDELWHDGVC 1525
Fly 2456 PVVISALKPFLSSSLPADVVTVQDASLDALCMLRVIHALNRHWDHLYGCVVRQNIIPQSDFIHPK 2520
|.|.:.|:.:|..: |.:.:|.:|.|||.:.:|||:||::|:|.:||...:.:.|||.|:||:.|
Mouse 1526 PSVANPLEVYLIPT-PPENITFEDPSLDVILLLRVLHAISRYWYYLYDNAMCKEIIPTSEFINSK 1589
Fly 2521 IMAKANRQLQDPLVIMTGNLPQWLPQIGMACPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDL 2585
:.|||||||||||||||||:|.||.::|..|||.|||:||.:|||.|:||||||:||||||.|::
Mouse 1590 LTAKANRQLQDPLVIMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEI 1654
Fly 2586 NAAESSE-RVAPRLDRRKRAISRTEILKQAEHILQDFGHSKALLEIQYENEVGTGLGPTLEFYAL 2649
|.::|.: ||||||||:||.::|.|:|||||.::||.|.|:|:||||||||||||||||||||||
Mouse 1655 NQSDSQDSRVAPRLDRKKRTVNREELLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTLEFYAL 1719
Fly 2650 VSAELQRTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSST 2714
||.||||.||.||.|.: ||:
Mouse 1720 VSQELQRADLCLWRGEE------VTL--------------------------------------- 1739
Fly 2715 TTTTTTAQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAA 2779
|:..|:.|.
Mouse 1740 ------------------------------------SNPKGSQEG-------------------- 1748
Fly 2780 IDNPSSTTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKAKFKFL 2844
|.|:..:.|||.||.|:::|...:.|.|.||:||
Mouse 1749 -------------------------------TKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRFL 1782
Fly 2845 GKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSD 2909
||.||||:||.|::|||..||||:|::.:|.|:...||..:.|.|..::..|:|:|||::.:..|
Mouse 1783 GKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQD 1847
Fly 2910 PNIDAMEKTEKIEQLDLDGCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFL 2974
.:.........:|.|.::||.:.||||||.|||..||||.:||:|.|||:|||.:|:.||.:|.|
Mouse 1848 KSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWAL 1912
Fly 2975 IEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFHQ 3039
.|||.:||::.|:||:||||:..|:.||||||:.:.|||.:: .|:.|.|.|.||.|||:..
Mouse 1913 NEGVCRQFDSFRDGFESVFPLCHLQYFYPEELDQLLCGSKAD----TWDAKTLMECCRPDHGYTH 1973
Fly 3040 DSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSV 3104
||:|:::|:|||:|::.::||.||||||||||||.|||::|.|||||||||.:..:||:|:||||
Mouse 1974 DSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSV 2038
Fly 3105 MTCVNYLKLPDYSSREVMRQKLKVAANEGSMSFHLS 3140
||||||||||||||.::||.||.:||.||..|||||
Mouse 2039 MTCVNYLKLPDYSSIDIMRDKLLIAAREGQQSFHLS 2074
| 
