DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and PLEKHA7

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	XP_024304124.1	Gene:	PLEKHA7 / 144100	HGNCID:	27049	Length:	1365	Species:	Homo sapiens

Alignment Length:	1019	Identity:	187/1019 - (18%)
Similarity:	323/1019 - (31%)	Gaps:	365/1019 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SQSLSALTEGQH------DDGGSTATSATLANKTSGTNTTSASNHSSQRRRNNNTNSNRNKSHHK 65
            ||..|.|.:.:|      .|..|.....||..:..|.:.:...|:.:..:      |.|:.|...
Human   426 SQRKSNLAQVEHWARAQKGDSRSLPLDQTLPRQGPGQSLSFPENYQTLPK------STRHPSGGS 484

  Fly    66 N-EKRNAPATSGPAVSSSVDVVPATSTAS----ATSTRRS--------------RSQGRHSSAAA 111
            : ..||.|:          |...|...||    ::..||:              |.|.||.|..|
Human   485 SPPPRNLPS----------DYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTA 539

  Fly   112 ---LSSKESQIPKRSVGAIRSPSS----PAFNSIPVVSDQSLSPGSRKRQLNQHNNSNNKASSSH 169
               |.|.|.....||...:..|.|    |:.:.||......:.|..|                .|
Human   540 PICLGSPEFTDQGRSRSMLEVPRSISVPPSPSDIPPPGPPRVFPPRR----------------PH 588

  Fly   170 QSAPGGDQLVCAPLKKRRLQQSLGSGICEGAVEINLGAASFDHTPRQASGDCVAQRTRSKTISPE 234
            ..|   :::...|..:||            :|:|:||     .:||:|.|
Human   589 TPA---ERVTVKPPDQRR------------SVDISLG-----DSPRRARG--------------- 618

  Fly   235 ELPSTSSAAAARHHQIRPSASSTSFSSSHRNKRKASIGGSIAAVETTPHRGTAAARAGRS----- 294
                         |.::        :|||.::|      |:.::....|..:|.:..|:|
Human   619 -------------HAVK--------NSSHVDRR------SMPSMGYMTHTVSAPSLHGKSLEELS 656

  Fly   295 ---GNLLNYYRKTRKVSHTRSSQKSEKQ----SIPAEDTTANRNGSAGSGSSSKSGVIPKNRKSL 352
               ..|..:..|...|.:...||..:.|    :..|:||..                  :.:|.|
Human   657 LLLTRLRRHQAKLASVRNFAISQLLQHQLTFPTCQADDTYL------------------QLKKDL 703

  Fly   353 RHSQQNLLDTEAA-----EVESAAAETGGEQQSEHGNLDVIDQLPTPEAGPNQSEASGIHNQSQL 412
            .:....:.:.|..     :|...:|.....::|..|.    |.|......|.:...|....:..:
Human   704 EYLDLKIKNNEPLINVLYKVLKKSARGCRPRRSMTGR----DLLKDRSLKPVKIAESDTDVKLSI 764

  Fly   413 EADRQPVVQDEDDEEDDEEEEEEEEEEVGFYGIVNSAGSSYEEDTQIVAEEDEITTEEEVDDEDD 477
            ..::..|:||.:|:....:|.:::.|.|  ..:::.....|.:..|.:   ::|..::::..||.
Human   765 FCEQDRVLQDLEDKIRALKENKDQLESV--LEVLHRQMEQYRDQPQHL---EKIAYQQKLLQEDL 824

  Fly   478 DEIEEEDLSESEFAQQLIGELGGERQQPQRATNNAKKTKNNTPAVAAASTIKATTTATTSSGYQQ 542
            ..|.              .||..|..:.:.|.|...|.:|:      ...:|.|...      |.
Human   825 VHIR--------------AELSRESTEMENAWNEYLKLEND------VEQLKQTLQE------QH 863

  Fly   543 RAAPHGQGAAP-----------GAGGGGPRATRSSNSNSSNNVVDYSIMPHLTTVATTTPHALTP 596
            |.|...|..:.           .||       .|:|..:...:|:....|...|| ...||...|
Human   864 RRAFFFQEKSQIQKDLWRIEDVTAG-------LSANKENFRILVESVKNPERKTV-PLFPHPPVP 920

  Fly   597 QQHQQQRQPPQPPS----------------HQQQQVHQQQQPPQLLPTHQFAHLSSFVTPTAAAA 645
            .....:.:||..||                ..|..|..:..||||...     .|...:||.|
Human   921 SLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKV-----TSPLQSPTKA-- 978

  Fly   646 AAAAAAHYPPASAAAAYFAQQQHHQHQHQHQQQHVQQAQAPQPHYYHSSVAVLHQPPPHHFTSTG 710
                                           :..||:.:||              |.|
Human   979 -------------------------------KPKVQEDEAP--------------PRP------- 991

  Fly   711 AGPPPALFQQQAPPQLTRYTPATATTAATFVPPQQQQVVYNPQQQQHSSLR--------RSSRGK 767
              |.|.|:..:..|      ||        |||..::...    .:|:|:|        |....:
Human   992 --PLPELYSPEDQP------PA--------VPPLPREATI----IRHTSVRGLKRQSDERKRDRE 1036

  Fly   768 TGSCVSSAAAAQQQQHHQQQQHSSAAAAVQQ------------QLLPPPG----TYQYQQVGGNT 816
            .|.||:..:..:.:.:..:.:.::.:..:.|            |.||..|    |.:.||  .:|
Human  1037 LGQCVNGDSRVELRSYVSEPELATLSGDMAQPSLGLVGPESRYQTLPGRGLSGSTSRLQQ--SST 1099

  Fly   817 VVVAVRHQQQLQQQQQQ----QQQLALHH----QHQQQQHQQQQQQHQQQQHQ----QQQRATLV 869
            :...|..::.|..:..:    :.:.||..    .||:.:...::|..:.::||    ::::.||.
Human  1100 IAPYVTLRRGLNAESSKATFPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLG 1164

  Fly   870 Q----------------PGFLFSYRSNQPQQQQQPAQQIHQGPK 897
            |                ||.|.|::..| ....|..:::.||.|
Human  1165 QGERTGLPSSRYLSRPLPGDLGSWKREQ-DFDLQLLERVVQGEK 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669	6/42 (14%)
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058
PLEKHA7	XP_024304124.1	WW	11..40	CDD:306827
		WW	56..85	CDD:306827
		PH_PEPP1_2_3	159..281	CDD:270068
		NESP55	<299..460	CDD:115071	9/33 (27%)
		DUF1640	779..905	CDD:311647	27/163 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900