DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and HECTD2

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_001271203.2	Gene:	HECTD2 / 143279	HGNCID:	26736	Length:	780	Species:	Homo sapiens

Alignment Length:	944	Identity:	183/944 - (19%)
Similarity:	321/944 - (34%)	Gaps:	336/944 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  2341 SPLVSEQPETDNESETLLGNASIWVQQHTIHYRPVEEEVTSGAAA---------GAASSSSSCSS 2396
            :|...|:...::|.|.|               .|:   |::||.|         |..|:.||..|
Human    18 APAPEERKGKESEREKL---------------PPI---VSAGAGATAGLDRGAKGQISTFSSFIS 64

  Fly  2397 GVQKQQSSSSSASS------------------CVNA-----TSSCSSSSGVASGGGSLTKKAHKS 2438
            .|..::.::.:.||                  |::.     ||..:|||
Human    65 AVSPKKEAAENRSSPAHLVFPNIKNVREPPPICLDVRQKQRTSMDASSS---------------- 113

  Fly  2439 SSKFMRKKTELWHEGIAPVVISALKPF-----------------------------LSSSLPADV 2474
                 ..|..:..|.|.|:....:|.|                             |:::...|.
Human   114 -----EMKAPVLPEPILPIQPKTVKDFQEDVEKVKSSGDWKAVHDFYLTTFDSFPELNAAFKKDA 173

  Fly  2475 V----TVQDASLDA-------------------LCMLRVIHALNRHW------DHL--------- 2501
            .    |::|:.::|                   ..:..:|::|.|.|      |.|
Human   174 TASFNTIEDSGINAKFVNAVYDTLLNTPQDVQKTVLKGIINSLLREWKGPRTKDDLRAYFILLQN 238

  Fly  2502 -----------YGCVVRQ-NIIPQSD---FIH------PKIMAKANRQLQDPLV-IMTGNL---- 2540
                       |..::|| ..:.::|   .:|      .::..|..:||.:.|: .::..|
Human   239 PQFNNTSTYVIYAHLLRQIATLVEADHHFLVHWFKKQYSRLSQKRFKQLVERLLQFISLRLFPAK 303

  Fly  2541 PQWLPQIGMACPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDLNAAESSERVAPRLDRRKRAI 2605
            |:..|.| ..|.:..|...:.|              .||:|..:|    ....:.|..|.....:
Human   304 PEEFPPI-TKCSWWIPSAAKVL--------------ALLNTANNL----VHPPLIPYTDFYNSTL 349

  Fly  2606 SRTEILKQAEHILQDFGHSKALLEIQYENEVGTGLGPTLEFYALVSAE---LQRTDLGLWNGSDS 2667
            ...::::: .|..|:||:|......||            .|...|:|:   :||         ||
Human   350 DHIDLMEE-YHTWQNFGNSHRFSFCQY------------PFVISVAAKKIIIQR---------DS 392

  Fly  2668 YKQNSVTIVDVVKANSAVLHIEDALEATTTDQN----TPAVAGASLVSSSTTTTTTTAQQHQHPP 2728
            .:|    ::::.:.:.    ::........|.|    ...|....|||.|....|.
Human   393 EQQ----MINIARQSL----VDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDELTR--------- 440

  Fly  2729 TRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPSSTTTATTVV 2793
            .|:..:..:..:..|:..::    ..|..:....::|.|.|
Human   441 KRADLKKKLKVTFVGEAGLD----MGGLTKEWFLLLIRQIF------------------------ 477

  Fly  2794 QHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAK----AKFKFLGKFMAKAVMD 2854
                                 |..:|:|  ...|.|.....:..|    ::|:.:|..|..||.:
Human   478 ---------------------HPDYGMF--TYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYN 519

  Fly  2855 SRMLDLPFSLPFYRWLVS-------EEHSIGLA-----DLMRVAPEVQNTLVRLQDLVRQREYIL 2907
            |..||:.|....|:.|:|       :...:|:.     ||.::.||:.:.|         .|.:.
Human   520 SITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGL---------SELLS 575

  Fly  2908 SDPNIDA-MEKTEKIEQLDLDGCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTY 2971
            .:.|::. ...|.::.|        .:.|:      ..:..|..||....||..|..:|:.|.|.
Human   576 HEGNVEEDFYSTFQVFQ--------EEFGI------IKSYNLKPGGDKISVTNQNRKEYVQLYTD 626

  Fly  2972 WFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHG 3036
            :.|.:.:.|||.|...||.||.....|.:..|||:|.:.|||.....|:      ||.|.:.| |
Human   627 FLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPDLDMHA------LQRSTQYD-G 684

  Fly  3037 FHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYL 3101
            :.:....|:|.::::..:..|.|:..|.|.|||.|:|.||...|       ...:.:|:...:.|
Human   685 YAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADL-------NFKISKNETSTNCL 742

  Fly  3102 PSVMTCVNYLKLPDYSSREVMRQKL--KVAANEG 3133
            |...||.|.|.||.|.|::.::|||  .::.:||
Human   743 PVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEG 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	90/335 (27%)
HECTD2	NP_001271203.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		10/45 (22%)
HECTD2	NP_001271203.2	HECTc	421..778	CDD:238033	103/453 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900