DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and Magi2

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_446073.2	Gene:	Magi2 / 113970	RGDID:	621855	Length:	1277	Species:	Rattus norvegicus

Alignment Length:	916	Identity:	162/916 - (17%)
Similarity:	273/916 - (29%)	Gaps:	298/916 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 EVESAAA--ETGGEQQSEHGN-----------LDVIDQLPTPEAGPNQSEASGIHNQSQLEADRQ 417
            |:|.:.|  |:|..:.:.:|.           |:|.||: .|.|.|: :|.....|:|....::.
  Rat   165 ELEKSGALLESGTYEDNYYGTPKPPAEPAPLLLNVTDQI-LPGATPS-AEGKRKRNKSVTNMEKA 227

  Fly   418 PVVQDEDDEEDDEEEEEEEEEEVGFYGIV----------NSAGSSYEEDTQ-----IVAEEDEIT 467
            .:        :..||||||...|...|:|          .|||:|.|..:|     :.::.:|:
  Rat   228 SI--------EPPEEEEEERPVVNGNGVVITPESSEHEDKSAGASGETPSQPYPAPVYSQPEEL- 283

  Fly   468 TEEEVDDEDDDEIEEEDLSES-----EFAQQLIGE-----------------LGGERQQPQRATN 510
             ::::||....:.||.:.|:.     |.|....||                 |..:.:..:....
  Rat   284 -KDQMDDTKSTKPEENEDSDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPAEECKE 347

  Fly   511 NA----------------------KKTKNNTPAVAAASTIKATTTATTSSGYQQRAAPHGQ-GAA 552
            |.                      ::|:...|.:.|...:            ||...||.: |..
  Rat   348 NELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKL------------QQHNMPHTELGTK 400

  Fly   553 PGAGGG---GPRATR----------SSNSNSSNNVVDYSIMPHLTTVATTTPHALTPQQHQQQRQ 604
            |....|   .|..||          |:....||....::|:           ....|.:..|.:.
  Rat   401 PLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTII-----------GGDEPDEFLQVKS 454

  Fly   605 P-PQPPSHQQQQVHQQQQPPQLLPTHQFAHLSSFV------TPTAAAAAAAAAAHYP-------P 655
            . |..|:.|..::........:.......|..:.|      .|...:........||       |
  Rat   455 VIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDP 519

  Fly   656 ASAAAAYFAQQQ-------HHQHQHQHQQQHVQQAQAPQPHYYHSSVAVLHQPPPHHFTS----- 708
            |::.....|..:       :.:|.::...:::.:..        .||..:...|||...|
  Rat   520 ANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTS--------QSVPDITDRPPHSLHSMPADG 576

  Fly   709 --TGAGPPPALFQQQAPPQLTRYTPATATTAATFVPPQQQ---QVVYNPQQQQHSSLRRSSRGKT 768
              .|..||| :.........:..|.|...| .|.|...|.   .:..:|..|:...: ...:|..
  Rat   577 QLDGTYPPP-VHDDNVSVASSGATQAELMT-LTIVKGAQGFGFTIADSPTGQRVKQI-LDIQGCP 638

  Fly   769 GSCVSSAAAAQQQQHHQQQQHSSAAAAVQQQLLPPPGTYQYQQVGGNTVVVAVR----------- 822
            |.|.........||:.|...|:.....::.  .|         ||..|.::..|
  Rat   639 GLCEGDLIVEINQQNVQNLSHTEVVDILKD--CP---------VGSETSLIIHRGGFFSPWKTPK 692

  Fly   823 -HQQQLQQQQQQQQQL-------------ALHHQ-----------HQQQQHQQQQQQHQQQQHQQ 862
             ...:.:.|...|..|             |||..           .:...::..::.....:.:|
  Rat   693 PMVDRWENQGSPQTSLSAPAVPQSLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQ 757

  Fly   863 QQRATLVQPGFLFSYRSNQPQQQQ--------------------QPAQQIHQGPKVTHSSAASDA 907
            |     |.|...|...|:.|..::                    :|.|.|..|..:...||..|
  Rat   758 Q-----VPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRD- 816

  Fly   908 LTYSLMAQQPPSGPPHAGGQQI----TPGANSANLSIVAAALSAARDVGGGSDGGGS-------- 960
                        |..|.|.:.:    .|.|...:..::.....|||:        |.
  Rat   817 ------------GRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARN--------GQVNLTVRRK 861

  Fly   961 ---AGGATPATGASASSVGNTSAVGASSSSNSSAGQAASSNSNNVTATGSGSAPGGGPTSTGTTS 1022
               .|...|..|.|..||       ::..|:..:..|..:|||:...:.:.|.|.|..:.:..||
  Rat   862 VLCGGEPCPENGRSPGSV-------STHHSSPRSDYATYANSNHAAPSSNASPPEGFASHSLQTS 919

  Fly  1023 GT--QHGSGSGAAAAVDSESDDSEVGRLQALLEARGLPPHLFGALGPRVTHILHRTIGNSSSSKA 1085
            ..  ......|....:.|..:..|.|       |....||..|           |.|..|.:.:.
  Rat   920 DVIIHRKENEGFGFVIISSLNRPESG-------ATITVPHKIG-----------RIIDGSPADRC 966

  Fly  1086 NQLLQG 1091
            .:|..|
  Rat   967 AKLKVG 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669	10/49 (20%)
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058
Magi2	NP_446073.2	PDZ_signaling	22..96	CDD:238492
		GuKc	118..291	CDD:214504	34/137 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..308		27/113 (24%)
		Interaction with DDN. /evidence=ECO:0000250	302..381		8/78 (10%)
		WW	304..333	CDD:395320	4/28 (14%)
		WW	350..381	CDD:197736	2/30 (7%)
		PDZ	428..509	CDD:214570	11/91 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..575		6/18 (33%)
		PDZ	602..683	CDD:214570	18/93 (19%)
		MAGI_u5	687..758	CDD:406953	6/70 (9%)
		PDZ	775..861	CDD:214570	16/106 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..913		13/50 (26%)
		PDZ_signaling	920..1007	CDD:238492	13/71 (18%)
		PRK10263	<1007..>1135	CDD:236669
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1011..1130
		PDZ_signaling	1140..1220	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900