DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and Plekha5

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	XP_006506926.1	Gene:	Plekha5 / 109135	MGIID:	1923802	Length:	1270	Species:	Mus musculus

Alignment Length:	923	Identity:	162/923 - (17%)
Similarity:	273/923 - (29%)	Gaps:	255/923 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SLSALTEGQHDDGGSTATSATLANKTSGTNTTSASNHSSQRRRNNNTNSN-----------RNKS 62
            ||:.:..|.|.:.|..||.|.  .....||:........:.::.......           ||..
Mouse   389 SLADVRGGSHPNAGPLATEAD--RVIQRTNSMQQLEQWIKVQKGRGLEEEPRGVISYQTLPRNMP 451

  Fly    63 HHKNE--------KRNAPATSGPAVSSSVDVVPATSTASATSTRRSRSQGRHSSAAALSS----- 114
            .|:.:        .|..|..|.....|...|..:....:.......|...|..:...|..
Mouse   452 SHRAQILARCPEGYRTLPRNSKTRPESICSVTSSGHEKTGPGAEEKRRSMRDDTMWQLYEWQQRQ 516

  Fly   115 ---KESQIPKRSVGAIRSP------SSPAFNSIP-------VVSDQSLSPGSRKR---------- 153
               |:|.:|:.  |.:.||      |....:|||       ..:.|..||....|
Mouse   517 FYHKQSTLPRH--GCLSSPKAMVQVSDQTMHSIPTSPSHGSAAAYQGFSPQRTYRSEVTSPIQRG 579

  Fly   154 -----QLNQHNNSNNKASSSHQSAPGG----------------DQLVCAPLKKRRLQQSLGSGIC 197
                 :.::.::..:...:..:|.|.|                ::|....:|.||.|..| |.:.
Mouse   580 DVTIDRRHRPHHPKHVYVADRRSMPAGLTLQAVSPQSLQGRTPEELTLLLIKLRRQQAEL-SSVR 643

  Fly   198 EGA----VEINLGAASFDHTPRQASGDCVAQRTRSKTI-SPEELPSTSSAAAARHHQIRPSASST 257
            |..    :::.|.|    |:|:   .:.::...:..|| ...::..........|..|..||...
Mouse   644 EHTLAQLMQLKLEA----HSPK---NEILSHHLQRNTIYLDHQMKENEPIITMVHTMIENSALRP 701

  Fly   258 S-FSSSHRNKRKASIGGSIAAVETTPHRGT-------AAARAGRSGNLLNYYRKTRKVSHTRSSQ 314
            . :....|.|.|.    |:..:.....|||       .|....:...|....:..|.:.......
Mouse   702 QLYQQFLRQKNKI----SLYCLSQDECRGTLYKYRPEEAGIDAKLSRLCEQDKVVRALEEKLQQL 762

  Fly   315 KSEKQSIPAEDTTANRNGSAGSGSSSKSGVIPKNRKSLRHSQQNLLDT------EAAEVESAAAE 373
            ..||.::.....:|::.....:.:.:....:...|..|   |..||.|      ..||:|.|..|
Mouse   763 HKEKYTLEQALLSASQEIEMNADNPAAIQTVVLQRDDL---QNGLLSTCRELSRATAELERAWRE 824

  Fly   374 TG--------------------GEQQSEHGNL-------------DVIDQLPTPEAGPNQSEASG 405
            ..                    ||.|||...:             ||::.|...:.....||..|
Mouse   825 YDKLEYDVTVTRDQMQGQLDRLGEVQSESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGSSETVG 889

  Fly   406 I------------HNQSQLEADRQPVVQDEDDEE---------DDEEE------------EEEEE 437
            :            ..:.::...|.|:.:..|..|         .|...            |:::.
Mouse   890 LAGSKPFSSVKYKSEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEDKKI 954

  Fly   438 EEVGFYGIVNSAGSSYEEDTQIVAEEDEITTEEEVDDEDDDEIEEEDLSESEFAQQLIGE----- 497
            .:|..|   ...||....|.::...|.|:||..|||:.:.:| :.|.:||:| |..:.|.
Mouse   955 HQVQGY---PRNGSHCGPDYRLYKSEPELTTVAEVDESNGEE-KSEPVSETE-APVVKGSHFPVG 1014

  Fly   498 --LGGERQQPQRAT-------NNAKK-----TKNNTPAVAAASTIKATTTATTSSGYQQRAAPHG 548
              |..:...|:.:|       ...||     |:....||......::.....|.....:|...|.
Mouse  1015 VPLRTKSPTPESSTIASYVTLRKTKKMVELRTERPRSAVEQLCLAESARPRMTVEEQLERIRRHQ 1079

  Fly   549 QG-------AAPGAGGGGPRATRSS------NSNSSNNVVDY-------SIMPHLTTVATTTPHA 593
            |.       .....|...|...|.|      .....:||.:.       .:.|...|.|....|.
Mouse  1080 QACLREKKKGLSVLGASDPSDVRDSPLRLTQTLRRDDNVKELDTVHRENDVKPDYETPAAQCAHL 1144

  Fly   594 --LTPQ--------QHQQQRQPPQPPSHQQQQVHQQQQPPQLLPTHQFAHLSSFVTPTAAAAAAA 648
              ..||        :..:....|:|.....::|.::::..:.:      |.....:|....|...
Mouse  1145 EDAEPQNADIGRKLKRSEMLYTPEPNGMASEEVTEKERQKEQV------HADGSCSPQEETAMTE 1203

  Fly   649 AAAHYPPASAAAAYFAQQQHHQHQHQHQQQHVQQAQAPQPHYYHSSVAVLHQPPPHHFTSTGAGP 713
            .....||..|             :..|:::....:..|.|.....:...:....|...:||.|.|
Mouse  1204 HQMEGPPEEA-------------ESLHEEEETLASCEPAPEIPRENQTTVRSLSPSPDSSTAADP 1255

  Fly   714 PPALFQQQAPPQL 726
            |       .||||
Mouse  1256 P-------TPPQL 1261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669	11/39 (28%)
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058
Plekha5	XP_006506926.1	WW	13..42	CDD:366073
		WW	59..88	CDD:366073
		PH_PEPP1_2_3	165..268	CDD:270068
		Smc	<623..>864	CDD:224117	47/255 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900