DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and Ube3c

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	NP_598668.1	Gene:	Ube3c / 100763	MGIID:	2140998	Length:	1083	Species:	Mus musculus

Alignment Length:	1206	Identity:	237/1206 - (19%)
Similarity:	394/1206 - (32%)	Gaps:	436/1206 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  2105 LERLSSILFKLNGSYHDCLDALLE-------LKTILLESDISPFEVNHS---GLIKAMLNYMTSE 2159
            ::||.|:..:|   ..:|.|..|.       |:....|:...|...:.|   .:|:.:|:||. .
Mouse   144 IKRLMSLCCRL---LQNCSDDSLNVALPMRMLEVFTSENTYLPVLQDSSYVVSVIEQILHYMV-H 204

  Fly  2160 TGLVER-----DARLRSFMHVFAGLPLEP----LLQNVGQMPTIEPI--------------AFGA 2201
            :|....     :::|.|.:. ::.|...|    ||:||     ::|:              .|.|
Mouse   205 SGYYRSLYLLINSKLPSSIE-YSDLSRVPIAKILLENV-----LKPLHFTYSSCPEASRHQVFSA 263

  Fly  2202 FVAKLNGC--VTQLEQFPVKVHD-----FPAGPGGRSNQSALRFFNTHQLKCNLQRHPQCNNL-- 2257
            |..:..|.  ..|:..|.:....     ||..|          |.|. .|....|...:|:.:
Mouse   264 FTEEFLGAPFTDQIFHFVIPAFADAQTVFPYEP----------FLNA-LLLLESQSSKRCSGVPW 317

  Fly  2258 ---------RQWKGGTVKIDPLAMVQAIERYL-------VVRGYGGIRADSDDDSEE------DM 2300
                     ..:.|...:...|..::.::.:|       ...|.....:||:||:||      ..
Mouse   318 LFYFVLTVGENYLGALSEDGLLVYLRVLQTFLSQLPASPTGTGCPDSTSDSEDDNEETDQPNSPE 382

  Fly  2301 DDNVAAVVLSQASFRHKLQFTIGDHVLPYNMTVYQAVKQFSPLVSEQPETDNESETLLGNASIWV 2365
            |..|:|..:::...| ||                              :|..::.|||.  .:|.
Mouse   383 DGRVSAPYITEECLR-KL------------------------------DTKQQTNTLLN--LVWR 414

  Fly  2366 QQHTIHYRPVEEEVTSGAAAGAASSSSSCSSGVQKQQSSSSSA----SSCVNATSSCSSSSGVAS 2426
            ..       ..|||.:..|       |.|.:.:.:.:......    |...||
Mouse   415 DS-------ASEEVFTRMA-------SICHTLMVQHRMMVPKVRLLYSLAFNA------------ 453

  Fly  2427 GGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVISALKPFLSSSLPADVVTVQDASLDALCMLRVI 2491
                          :|:|   .||              ||.||:...::|..        |:.::
Mouse   454 --------------RFLR---HLW--------------FLISSMTTQMITGS--------MVPLL 479

  Fly  2492 HALNRHWDHLYGCVV----RQNIIP-----QSDFIHPKIMAKANRQLQDPLVIMTGNLPQWLPQI 2547
            ..::|      |..:    ...|||     .|.|.|..|....|....||:.:           :
Mouse   480 QLISR------GSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEV-----------V 527

  Fly  2548 GMACPFLFPFETRHLLFYATSFDRDRALQRLL----DTTPD-----------LNAAESSE----- 2592
            |.....:.||....|:..:... ||..|..:.    :|.|:           :....:||
Mouse   528 GQRQSSMMPFTLEELILLSRCL-RDACLGIIKLAYPETKPEVREEYVTAFQSIGVTTNSEMQQCI 591

  Fly  2593 -----------RVAPRL-------DRRKRAISRTEILKQAEHILQD------------------- 2620
                       :|...|       |.|:........|.:.|.|..|
Mouse   592 QMEQKRWVQLFKVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRM 656

  Fly  2621 --FGHSKALLEIQYEN-----------EVGTGLG---PTLE----FYALVSAELQRTDLGLWNGS 2665
              .|..::.||:..|:           .:.|.|.   |..|    |..|:.|:.|..
Mouse   657 GRIGPLQSTLEVGLESLPLSVSEERQLAILTELPFVVPFEERVKIFQRLIYADKQEV-------- 713

  Fly  2666 DSYKQNSVTIVDVVKANSAVLHI-EDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQHQHPPT 2729
                |.....:|.:.......:| |||.     |:.:|                     ...|..
Mouse   714 ----QGDGPFLDGINVTIRRNYIYEDAY-----DKLSP---------------------ENEPDL 748

  Fly  2730 RSSSRSHVLRSGAGQQPVEHSSSSAGAN-----ENALNMVIAQQFSDTNSANPAAIDNPSSTTTA 2789
            :...|.|:|.:        |....||.:     ...||.::...|            ||:.....
Mouse   749 KKRIRVHLLNA--------HGLDEAGIDGGGIFREFLNELLKSGF------------NPNQGFFK 793

  Fly  2790 TTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKA---KFKFLGKFMAKA 2851
            ||         |..:               |:|.|..      ||....:   .:.|||:.:.||
Mouse   794 TT---------NEGL---------------LYPNPAA------QMLVGDSFARHYYFLGRMLGKA 828

  Fly  2852 VMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDAME 2916
            :.::.:::|||:..|...|:.....:.:..|..:.|||...|:.|:..
Mouse   829 LYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYRNLLFLKSY----------------- 876

  Fly  2917 KTEKIEQLDLDGCPIADLGLDFVLP----GHAN-IELCRGGRDTPVTVHNLHQYISLVTYWFLIE 2976
             .|.:|          :|||:|.:.    |.|. :||..||:|.|||..|...||.||..:.|.:
Mouse   877 -EEDVE----------ELGLNFTVVNNDLGEAQVVELKFGGKDIPVTGANRIAYIHLVADYRLNK 930

  Fly  2977 GVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDH--GFHQ 3039
            .::....|.|:|..:|..::.||||..:|::.:.  ||::...|..::|..     |::  |:..
Mouse   931 QIRPHCLAFRQGLANVVSLEWLRMFDQQEIQVLI--SGAQVPVSLEDLKSF-----TNYSGGYSA 988

  Fly  3040 DSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSV 3104
            |...|:..:.::..:..:|:|..|:|||...|.|..|||.|.|...|.....|..:     ||:.
Mouse   989 DHPVIKIFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLER-----LPTA 1048

  Fly  3105 MTCVNYLKLPDYSSREVMRQKLKVAANEGSMSFHLS 3140
            .||:|.||||::....::|.|| :.|.|.:..|.||
Mouse  1049 STCMNLLKLPEFYDEALLRSKL-LYAIECAAGFELS 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442
		HECTc	<2818..3138	CDD:294058	89/329 (27%)
Ube3c	NP_598668.1	Cis-determinant of acceptor ubiquitin-binding. /evidence=ECO:0000250	1..60
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..386		8/31 (26%)
		HECTc	723..1081	CDD:238033	110/474 (23%)
		HECTc	747..1080	CDD:214523	103/423 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900