DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ctrip and HUWE1

DIOPT Version :9

Sequence 1:NP_001189170.1 Gene:ctrip / 40596 FlyBaseID:FBgn0260794 Length:3140 Species:Drosophila melanogaster
Sequence 2:XP_016884680.1 Gene:HUWE1 / 10075 HGNCID:30892 Length:4501 Species:Homo sapiens


Alignment Length:3351 Identity:607/3351 - (18%)
Similarity:1014/3351 - (30%) Gaps:1198/3351 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SVKSQSLSALTEGQHDDGGSTATSATLANKTSGTNTTSASNHSSQRRRNNNTNSNRNKSHHKNEK 68
            |:.||..:|       ||.||.|||  :..:.|..:|...:...::.:..:..|...|...|..|
Human  2135 SINSQVFAA-------DGASTETSA--SGTSQGEASTPEESRDGKKDKEGDRASEEGKQKGKGSK 2190

  Fly    69 RNAPATS-----GPAVSSSVDV-------------------------------VPATSTASATST 97
            ...|.::     ...|.|.|.:                               :|.|..|....|
Human  2191 PLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQSELIKEDCSVLAFVLDHLLPHTQNAEDKDT 2255

  Fly    98 RRSRSQGRHSSAAALSSKESQIP-----KRSVG----------------AIRSPSSPAFNSIPVV 141
            .........|.|||.|..::|:.     |.::|                |:....|....|.|..
Human  2256 PALARLFLASLAAAGSGTDAQVALVNEVKAALGRALAMAESTEKHARLQAVMCIISTIMESCPST 2320

  Fly   142 SDQSLSPGSRKRQLNQHNNSNNKASSSHQSAPGGDQLVCAPLKKRRLQQSLGSGICEGAVEINLG 206
            |....|..::    .|||..||                   :.:..|::.|.:.:......::|.
Human  2321 SSFYSSATAK----TQHNGMNN-------------------IIRLFLKKGLVNDLARVPHSLDLS 2362

  Fly   207 AASFDHTPRQASGDCVAQRTRSKTIS-PEELPSTSSAAAARHHQIRPSASSTSFSSSHRNKRKAS 270
            :.:..:|...|   .....|.|:.:: |..|..:.||::....:.....:|...||   |::...
Human  2363 SPNMANTVNAA---LKPLETLSRIVNQPSSLFGSKSASSKNKSEQDAQGASQDSSS---NQQDPG 2421

  Fly   271 IGGSIAAVETTPHRGTAAARAGRSGNLLNYYRKTRKVSHTRSSQKSEKQSIPAE-------DTTA 328
            ..|. |.|:...|..|....|  .|::::...:|..|......:....|.:..|       |...
Human  2422 EPGE-AEVQEEDHDVTQTEVA--DGDIMDGEAETDSVVIAGQPEVLSSQEMQVENELEDLIDELL 2483

  Fly   329 NRNGSAGSGSSSKSGVIPKNRKSLRHSQQNLLDTEAAEVESAAAETGGEQQSEHGNLDVIDQLPT 393
            .|:|  |||:|:    |..:|.....||:::|..||....|.|:..   |.:...:::::|  |.
Human  2484 ERDG--GSGNST----IIVSRSGEDESQEDVLMDEAPSNLSQASTL---QANREDSMNILD--PE 2537

  Fly   394 PEAGPNQSEASGIHNQSQLEADRQPVVQDEDDEEDDEEEEEEEEEEVGFYGIVNSAGSSYEEDTQ 458
            .|....|.|.|...|            :||||.:|:||||||:                 |||.|
Human  2538 DEEEHTQEEDSSGSN------------EDEDDSQDEEEEEEED-----------------EEDDQ 2573

  Fly   459 IVAEEDEITTEEEVDDEDDDEIEEEDLSE-------------SEFAQQLIGELGGERQQPQRATN 510
               |:||   .||.|::|||:..|.:|.|             ..|.::  .:|..|......:..
Human  2574 ---EDDE---GEEGDEDDDDDGSEMELDEDYPDMNASPLVRFERFDRE--DDLIIEFDNMFSSAT 2630

  Fly   511 NAKKTKNNTPAVAAASTIKATTTATTSSGYQQRAAPHGQGAAPGAGGGGPRATRSSNSNSSNNVV 575
            :...:..|.|               |:.....|.|.| .....|:|....|.|:....:...   
Human  2631 DIPPSPGNIP---------------TTHPLMVRHADH-SSLTLGSGSSTTRLTQGIGRSQRT--- 2676

  Fly   576 DYSIMPHLTTVATTTPHALTPQQHQQQRQPPQPPSHQQQQVHQQQQPPQLLPTHQFAHLSSFVTP 640
                   |..:...|.|.:                |.....::|..||.:        |...:.|
Human  2677 -------LRQLTANTGHTI----------------HVHYPGNRQPNPPLI--------LQRLLGP 2710

  Fly   641 TAAAAAAAAAAHYPPASAAAAYFAQQQHHQHQHQHQQQHVQQAQAPQPHYYHSSVAVLHQPPPHH 705
            :|||.....::..|..|...|.........|........:..      .::|.......|     
Human  2711 SAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLD------DFFHDQSTATSQ----- 2764

  Fly   706 FTSTGAGPPPALFQQQAPPQLTRYT------------PATATTAATFVPPQQQQVVYNPQQQQHS 758
                 ||...::     |..|||:|            ...:....:.|  ...:.:.:.:.::..
Human  2765 -----AGTLSSI-----PTALTRWTEECKVLDAESMHDCVSVVKVSIV--NHLEFLRDEELEERR 2817

  Fly   759 SLRRSSRGKTGSCVSSAAAAQQQQHHQQQQHSSAAA--AVQQQL---LPPPGTYQYQQVGGNTVV 818
            ..||....:..:.::......::...|..|.:::.:  :.:|.|   .|.|.:  |.....:|..
Human  2818 EKRRKQLAEEETKITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDS--YPTTPSSTDA 2880

  Fly   819 VAVRHQQQLQQQQQQQQQLALHHQHQQQQHQQQQQQHQQQQHQQQQRATLVQPGFLFSYRSNQPQ 883
            .....::.|...|..|||                             .||..|..|    ...||
Human  2881 ATSESKETLGTLQSSQQQ-----------------------------PTLPTPPAL----GEVPQ 2912

  Fly   884 QQQQPAQQIHQGPKVTHSSAASDALTYSLMAQQP-------PSGPPHAGGQQITPGANSANLSIV 941
            :.|.||.:             ..:.|..||..:|       |||.......:::|.....:||..
Human  2913 ELQSPAGE-------------GGSSTQLLMPVEPEELGPTRPSGEAETTQMELSPAPTITSLSPE 2964

  Fly   942 AA----ALSAARDVGGGSDGGGSAGGATPATGASASSVGNTSAVGASSSSNSSAGQAASSNSNNV 1002
            .|    ||:|......||          |...:|.:|.....|||.:|::.||....|.|     
Human  2965 RAEDSDALTAVSSQLEGS----------PMDTSSLASCTLEEAVGDTSAAGSSEQPRAGS----- 3014

  Fly  1003 TATGSGSAPGGGPTSTGTTSGTQHGSGSGAAAAVDSE---SDDSEVGRLQAL----LEARGLPPH 1060
                  |.||..|.:.....|...|||..|....||.   |.:|...|..|:    .::||    
Human  3015 ------STPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADSRG---- 3069

  Fly  1061 LFGALGPRVTHILHRTIGNSSSSKANQLLQGLQSHDESQQLQAAIEMCQMLVMGNEDTLAGFPIK 1125
                       ||...:.::||.:                               ||.|||..:.
Human  3070 -----------ILEEPLPSTSSEE-------------------------------EDPLAGISLP 3092

  Fly  1126 Q-VVPALIQLLRMEHNFDIMNNACRALAYMLEALP--RSSGTVVEAVPVFLEKLQVIQCMDVAEQ 1187
            : |.|:.:..|..:...:::.|       .|...|  |::.:...:.|..:....|   .:|:.:
Human  3093 EGVDPSFLAALPDDIRREVLQN-------QLGIRPPTRTAPSTNSSAPAVVGNPGV---TEVSPE 3147

  Fly  1188 SLSAL------EILSRRHNKAILQANGISACLTYLDFFSIVAQRAALAIAANCCLNMHPEEFHFV 1246
            .|:||      |:|:::..:                     .||..||..|:....|.|..|   
Human  3148 FLAALPPAIQEEVLAQQRAE---------------------QQRRELAQNASSDTPMDPVTF--- 3188

  Fly  1247 AESLPLLARLLSQQDKKCIESVCSAFCRLVESFQHDGQRLQQIASPDLLKNCQ---------QLL 1302
            .::||...|....:|.:  :||.:                  :..||:....|         |..
Human  3189 IQTLPSDLRRSVLEDME--DSVLA------------------VMPPDIAAEAQALRREQEARQRQ 3233

  Fly  1303 LVTPAIL---NTGTFTAVVRMLSLMCCSCPDLAISLLRNDIAATLLYLLTGNAEPAAASATHVEL 1364
            |:...:.   :|...:|::|..:.......:..:...|..:.....:.:.|::.....|.::|:.
Human  3234 LMHERLFGHSSTSALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDT 3298

  Fly  1365 ISRSPSELY----ELTCLIGELMPRLPLDGIFAVDSLLDRPTLNTQ-------------DQVHWQ 1412
            :.|....|.    .|:||:              |...:|.|.|||.             ...||.
Human  3299 LLRLRGRLLLDHEALSCLL--------------VLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWV 3349

  Fly  1413 WRDDRGSWHNYSTIDSRLIEAANQSSEDEISLSTFGRTYTVDFHAMQQINEDTGTTRPVQRRLNH 1477
            .|.              |:....:|||.|:.:.|  ...|......::.::..|::....|.|:.
Human  3350 IRS--------------LLSILQRSSESELCIET--PKLTTSEEKGKKSSKSCGSSSHENRPLDL 3398

  Fly  1478 NYVAPMSAGQDLTTTSAGSAAAGGASTSAAAAAASSNNNNNNNNNPPGNSVNLNQVKRRPSLDAR 1542
            .:.....:...|:..|....||.|..|:......|....:...:...|::|:::     |.. |.
Human  3399 LHKMESKSSNQLSWLSVSMDAALGCRTNIFQIQRSGGRKHTEKHASGGSTVHIH-----PQA-AP 3457

  Fly  1543 IACLKEERGLAADFIKHIFNVLYEVYSSSAGPNVRYKCLRALLRMVYYATPELLRQVLKYQLVSS 1607
            :.|            :|:.:.|.                                          
Human  3458 VVC------------RHVLDTLI------------------------------------------ 3468

  Fly  1608 HIAGMLGSNDLRIVVGALQMAEILMRQLPDVFGTHFRREGVIYQFTQLTDPNNPICANPSPKPLS 1672
                                      ||..||.:||.:        |.|...|  |.:...:   
Human  3469 --------------------------QLAKVFPSHFTQ--------QRTKETN--CESDRER--- 3494

  Fly  1673 ATATPTANAGGSQSAPASANSLQVNPFFMDSAPGLSSASTTPSSSKHQSYSVKSFSHAMNALTAS 1737
                     |....:|.|:.|         |:.|:        .:......||     ::.:..|
Human  3495 ---------GNKACSPCSSQS---------SSSGI--------CTDFWDLLVK-----LDNMNVS 3528

  Fly  1738 AKGTPSGALDATSSSTTAGGYNYSSSAPSSSSGAPAAYFVTQQGDP--RQYVHFQQPAVPAPPPQ 1800
            .||..|    ..|...:|||...:|  |.|...:|....:.....|  |:.....:..:......
Human  3529 RKGKNS----VKSVPVSAGGEGETS--PYSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLI 3587

  Fly  1801 QELLPSGVQQQGQQVPQVIYQPHHQQPAHLVLASTSSGAASSSSSSSSSSSASALQHKMTDMLKR 1865
            ...||.....:.|                   |::.|||:|:::::|::|:.:......|     
Human  3588 SIALPENKVSEAQ-------------------ANSGSGASSTTTATSTTSTTTTTAASTT----- 3628

  Fly  1866 KAPPKRKSQSGGRAKSRQEDAAVAPAGSGPGGAPPSSSGSAMHELLSRATSLGSGNGGRSTPNSG 1930
            ..||                  .||.        |.:|..|:....:.:|.:.:.:...:||.: 
Human  3629 PTPP------------------TAPT--------PVTSAPALVAATAISTIVVAASTTVTTPTT- 3666

  Fly  1931 GGSGSSKSRFNAGNSSNAGSSKSSFLASLNPARWGRQTHQNHHHHHQQSQQQHHGLSKDSGNSNS 1995
                                  ::...|::|                                .:
Human  3667 ----------------------ATTTVSISP--------------------------------TT 3677

  Fly  1996 TGSGSGAGLAYTVSQHGAGSG-----AGGLNAAAVAASISKSISHANLLAAANRERARQWVREQA 2055
            .||.|.|    .||..|:.|.     :.||....:..|:....||                    
Human  3678 KGSKSPA----KVSDGGSSSTDFKMVSSGLTENQLQLSVEVLTSH-------------------- 3718

  Fly  2056 VDFVKRYTEQEAKRSKAASESGATQSGSSGVGLSSTGNTPLS-TAGSTNVLERLSSILFKLNGSY 2119
                            :.||.          ||....|..|. :.|.:...:.:..:|  |||:.
Human  3719 ----------------SCSEE----------GLEDAANVLLQLSRGDSGTRDTVLKLL--LNGAR 3755

  Fly  2120 HDCLDALLELKTILLESDISPFEVNHSGLIKAMLNYMTSETGLVERDARLRSFMHVFAGLPLE-P 2183
            |.......::.|:|.|..    |.|.....:|....::.:                  |||.| |
Human  3756 HLGYTLCKQIGTLLAELR----EYNLEQQRRAQCETLSPD------------------GLPEEQP 3798

  Fly  2184 LLQNV-GQMPTIEPIAFGAFVAKLNGCVTQLEQFPVKVHDFPAGPGGR-----------SNQSAL 2236
            ....: |:|.:       .|....|..:...::.|:         |||           |..|..
Human  3799 QTTKLKGKMQS-------RFDMAENVVIVASQKRPL---------GGRELQLPSMSMLTSKTSTQ 3847

  Fly  2237 RFFNTHQLKCNLQRHPQCNNLRQWKGGTVKIDPLAMVQAIERYLVVRGYGGIRADSDDDSEEDMD 2301
            :||                              |.::|.|   :.:|          ||:.    
Human  3848 KFF------------------------------LRVLQVI---IQLR----------DDTR---- 3865

  Fly  2302 DNVAAVVLSQASFRHKLQFTIGDHVLPYNMTVYQAVKQFSPLVSEQPETDNESETLLGNASIWVQ 2366
                     :|:.:.|....:|...|....::..||:|.          :.|::.::        
Human  3866 ---------RANKKAKQTGRLGSSGLGSASSIQAAVRQL----------EAEADAII-------- 3903

  Fly  2367 QHTIHYRPVEEEVTSGAAA-----GAASSSSSCSSGVQKQQSSSSSASSCVNATS-SCSSSSGVA 2425
                      :.|..|..|     .|.|.||...:.|::::|...     |:..| |...:..:|
Human  3904 ----------QMVREGQRARRQQQAATSESSQSEASVRREESPMD-----VDQPSPSAQDTQSIA 3953

  Fly  2426 SGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVISALKPFLSSSLPADVVTVQDASLDALCMLRV 2490
            |.|   |.:..|...:   :..||              |.||..|          |||.|     
Human  3954 SDG---TPQGEKEKEE---RPPEL--------------PLLSEQL----------SLDEL----- 3983

  Fly  2491 IHALNRHWDHLYGCVVRQNIIPQSDFIHPKIMAKANRQLQDPLVIMTGNLPQWLPQIGMACPFLF 2555
                   ||.|..|:                  |...:..|...::.                |.
Human  3984 -------WDMLGECL------------------KELEESHDQHAVLV----------------LQ 4007

  Fly  2556 PFETRHLLFYATSFD--------RDRALQRLLDTTPDLNAAESSERVAPRLDR-RKRAISRTEIL 2611
            |......|.:||..:        |:..|..:.|..|.|:.|..:......||. ..|..|...|.
Human  4008 PAVEAFFLVHATERESKPPVRDTRESQLAHIKDEPPPLSPAPLTPATPSSLDPFFSREPSSMHIS 4072

  Fly  2612 KQAEHILQDF-----GHSKALLEIQYENEVGTGLGPTLEFYALVS---------------AELQR 2656
            .......|.|     .|...|.:|..::......||   |..||.               .||:|
Human  4073 SSLPPDTQKFLRFAETHRTVLNQILRQSTTHLADGP---FAVLVDYIRVLDFDVKRKYFRQELER 4134

  Fly  2657 TDLGLWNGSDSYKQNSVTIVDVVKANSAVLHI------EDALEATTTDQNTPAVAGASLVSSSTT 2715
            .|.||                  :.....:|:      ||:..                      
Human  4135 LDEGL------------------RKEDMAVHVRRDHVFEDSYR---------------------- 4159

  Fly  2716 TTTTTAQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAI 2780
                  :.|:..|....:|.:::..|       .....||.......|:|:::           :
Human  4160 ------ELHRKSPEEMKNRLYIVFEG-------EEGQDAGGLLREWYMIISRE-----------M 4200

  Fly  2781 DNPSSTTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKAKFKFLG 2845
            .||......|:.....|.|.|.|........||                           |||:|
Human  4201 FNPMYALFRTSPGDRVTYTINPSSHCNPNHLSY---------------------------FKFVG 4238

  Fly  2846 KFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYIL-SD 2909
            :.:||||.|:|:|:..|:..||:.::.:  |:...|:..........||          |:| :|
Human  4239 RIVAKAVYDNRLLECYFTRSFYKHILGK--SVRYTDMESEDYHFYQGLV----------YLLEND 4291

  Fly  2910 PNIDAMEKTEKIEQLDLDGCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFL 2974
            .:....:.|...|..:...|.:.||     .|..|||         .||..|..:|:.||....:
Human  4292 VSTLGYDLTFSTEVQEFGVCEVRDL-----KPNGANI---------LVTEENKKEYVHLVCQMRM 4342

  Fly  2975 IEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFHQ 3039
            ...::||..|..|||..:.|.:.:.:|..:|||.:..|..:      .:|..|:.:... |.:..
Human  4343 TGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPT------IDIDDLKSNTEY-HKYQS 4400

  Fly  3040 DSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSV 3104
            :|..||:.:..|.|:::.::..|||||||:.::|..||.||.....|.:..:..:....|.|||.
Human  4401 NSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSA 4465

  Fly  3105 MTCVNYLKLPDYSSREVMRQKLKVAANEGSMSFHLS 3140
            .||.|.|.||.|.|.|.:|..|.:|..|.|..|.|:
Human  4466 HTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA 4501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ctripNP_001189170.1 Extensin_2 <688..731 CDD:252669 9/54 (17%)
WWE 1409..1481 CDD:128922 13/71 (18%)
FAM199X <1985..2074 CDD:292442 13/93 (14%)
HECTc <2818..3138 CDD:294058 87/320 (27%)
HUWE1XP_016884680.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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