DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and hecw2b

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	XP_003197660.3	Gene:	hecw2b / 100331355	ZFINID:	ZDB-GENE-101001-3	Length:	1472	Species:	Danio rerio

Alignment Length:	1629	Identity:	300/1629 - (18%)
Similarity:	487/1629 - (29%)	Gaps:	578/1629 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1619 RIVVGALQMAEILMRQLP--DVFG-THFRRE----------GVIYQFTQLT-DPNNPICANPSPK 1669
            |...|...::..|.|:||  .|.| .|||.|          |.:...:.:. ||.:|.......:
Zfish   304 RHTAGDQHVSYTLCRRLPTEHVSGQLHFRVEITFNGHEDAMGSLLGASAMNGDPGSPSDDEDVLQ 368

  Fly  1670 PLSATA---TPTANAGGSQSAPASANSLQVNP----FFMDSAPGLSSASTTPSSSKHQSYSVKSF 1727
            |:|...   :||.:.|.........:...::|    ...|.||.|  |...|:.:..|| |:..:
Zfish   369 PVSRMVRGPSPTGSEGSLHGDAFRPDECMMDPEEDRLLRDGAPDL--AEGAPAHTHRQS-SLNDY 430

  Fly  1728 SHAMNALTASAKGTPSGALDATSSSTTAGGYNYSSSAPSSSSGAP------AAYFVTQQGDPRQY 1786
                              |||..:....|.....:|:|...|..|      |...:....|...:
Zfish   431 ------------------LDAIEAPKPPGDRPLGASSPKLRSSFPTDTRLNAMLHIDSDEDEEGH 477

  Fly  1787 VHFQQPAVPAPPPQQELLPSGVQQQGQQVPQVIYQPHHQQPAHLVLASTSSGAASSSSSSSSSSS 1851
            .. :..|:....|:.|...|..:.:|:.         |.:....:.:..:|.|..:.:::|.|||
Zfish   478 AS-RDTALTNGMPRPEGHASSERGKGEV---------HVKNRERLESEAASSATDTEATASVSSS 532

  Fly  1852 ASALQHKMTDMLKRKAPPKRKSQSGGRAKSRQEDAAVA------------PA---GSGPGGAPPS 1901
            .:.                 |||:||.|:..||.||::            ||   ....|.||.:
Zfish   533 GTT-----------------KSQNGGGAEGGQEGAAISGGLTQSISSFQQPALRIQDEEGAAPQA 580

  Fly  1902 SS---GSAMHELLSRATSLGSGNGGRSTPNSGGGSGSSK--SRFNAGNSSNAGSSKSSFLASLNP 1961
            ||   ||:....:|.|::     ....|.|..||:.::.  .|.|:...:|........
Zfish   581 SSRTEGSSEAPAVSEASA-----SAIYTVNEVGGATATNQPERMNSSEMTNQEEEDEEI------ 634

  Fly  1962 ARWGRQTHQNHHHHHQQSQQQHHGLSKDSGNSNSTGSGSGAGLAYTVSQHGAGSGAGGLNAAAVA 2026
              |.|:      ...|.|..:....:.:.||.....:........|..:.||.:...|.......
Zfish   635 --WQRR------RSLQASGNESQAEAMELGNEVRRTADEAQAALITDGETGACAQVNGHQPMRSL 691

  Fly  2027 ASISKSISHANLLAAANRERARQWVREQAVDFVKRYTEQEAKRSKAASESGATQSGSSGVGLSST 2091
            .|:...||                 |.|.||      |......:|..:|.........|..::|
Zfish   692 PSVRHDIS-----------------RYQRVD------EPLPPNWEARIDSHGRIFYVDHVNRTTT 733

  Fly  2092 GNTPLSTAGSTNVLERLSSI--LFKLNGSYHDCLDALLELKTILLESDISPFEVNHSGLIKAMLN 2154
            ...| :...:..||:|.:||  :.:||..|......:...:|....:::.|.::..|.|    |:
Zfish   734 WQRP-TAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTITNERTEEQAAEMPPDDLTTSDL----LH 793

  Fly  2155 YMTSETGLVERD-----ARLRSFMHVFAGLPLEPLLQNVGQMPTI--EPIAFGAFVAKLNGC--- 2209
            :...|   ..||     |..||.:.:....|....|.:......:  .|.|:..|.:  |.|
Zfish   794 HSIPE---YRRDGVVGPASSRSRLTLLLQSPSAKFLTSPDFFTVLHSNPSAYRMFTS--NTCLKH 853

  Fly  2210 ---------------------VTQLEQFPVKVHDFPAGPGGRSNQSALRFFNTHQLKCNLQRHPQ 2253
                                 |..|..|..|..|.|.|...:.:.:...||..|..:
Zfish   854 MISKVRRDAHHFERYQHNRDLVAFLNMFANKQLDLPRGWEMKHDHTGKPFFVDHNCR-------- 910

  Fly  2254 CNNLRQWKGGTVKIDPLAMVQAIERYLVVRGYGGIRADSDDDSEEDMDD--NVAAVVLSQAS--- 2313
                     .|..|||...:|:.....::.....:.......:.|..||  :....||.:.|
Zfish   911 ---------ATTFIDPRLPLQSARPSSLLAHRQHLSRQRSHSAGEVGDDPRHAGPAVLPRPSNTF 966

  Fly  2314 --FRHKLQFTIGDHVLPYNMTVYQAVKQ---FSPLVSEQPETDNESETLLGNASIWVQQHTIHYR 2373
              .|::.|..:   .:.||..:...::|   |..|...|||.              ::.|::  |
Zfish   967 TANRNQCQDLV---PVAYNEKIVAFLRQPNIFDILQERQPEL--------------IRNHSL--R 1012

  Fly  2374 PVEEEVTSGAAAGAASSSSSCSSGVQKQQSSSSSASSCVNATSSCSSSSGVASGGGSLTKKAHKS 2438
            ...:.:.:..|:|.|..||...
Zfish  1013 EKVQFIRNEGASGLARLSSDAD------------------------------------------- 1034

  Fly  2439 SSKFMRKKTELWHEGIAPVVISALKPFLSSSLPADVVTVQDASLDALCMLRVIHALNRHWDHLYG 2503
                            ..:::|..:..:.|.:|.                   |||
Zfish  1035 ----------------LVILLSLFEEEVMSYVPP-------------------HAL--------- 1055

  Fly  2504 CVVRQNIIPQSDFIHPKIMAKANRQLQDPLVIMTGNLPQWLPQIGMA-----CPFLFPFETRHLL 2563
                         :||.       ..|.|......: ||..|....|     .|:...||.:...
Zfish  1056 -------------LHPS-------YCQSPRGSPVSS-PQNSPGTQRANARAPAPYKRDFEAKLRN 1099

  Fly  2564 FYATSFDRDRALQRLLDTTPDLNAAESSERVAPRLDRRKRAISRTEILKQAEHIL-----QDFGH 2623
            ||           |.|:|.   ...:...:|       |..|.|..:|:.|.:.:     :|...
Zfish  1100 FY-----------RKLETK---GYGQGPGKV-------KLIIRRDHLLEDAFNQIMCYSRKDLQR 1143

  Fly  2624 SKALLEIQYENEVGTGL-GPTLEFYALVSAELQRTDLGLWNGSDSYKQNSVTIVDVVKANSAVLH 2687
            ||  |.:.:..|.|... ||:.||:.|||.||.....||:    .|..|....|.:
Zfish  1144 SK--LYVSFVGEEGLDYSGPSREFFFLVSRELFNPYYGLF----EYSANDTYTVQI--------- 1193

  Fly  2688 IEDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSS 2752

Zfish  1194 ----------------------------------------------------------------- 1193

  Fly  2753 SAGANENALNMVIAQQFSDTNSANPAAIDNPSSTTTATTVVQHNTTTNNSSIITTTTTTSYVHAV 2817
                                 |...|.:||            |:..
Zfish  1194 ---------------------SPMSAFVDN------------HHEW------------------- 1206

  Fly  2818 HGLFPLPLGKSSKLPQMTKAKAKFKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADL 2882
                                   |:|.|:.:..|::...:||..|:.|||:.|:  .....|:||
Zfish  1207 -----------------------FRFSGRILGLALIHQYLLDAFFTRPFYKGLL--RIPCDLSDL 1246

  Fly  2883 MRVAPEVQNTLVRLQDLVRQREYILSDPNIDAMEKTEKIEQLDLDGCPIADLGLDFVLPGHANI- 2946
            ..:..|...:|..::|                    ..||.:           ||.....:..:
Zfish  1247 EYLDEEFHQSLQWMKD--------------------NDIEDM-----------LDLTFTVNEEVF 1280

  Fly  2947 ------ELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFEALREGFDSVFPIQRLRMFYPEE 3005
                  ||..||.:.||:..|..:||..:..|.:..||.:|.|:|..||..|...:.:.:|...|
Zfish  1281 GQITERELKPGGANIPVSEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARE 1345

  Fly  3006 LECVFCGSGSEQQHSRWEIKMLQESCRTDH--GFHQDSQAIQYLYEILASYNRDEQRAFLQFVTG 3068
            ||.|..|:.        ||.:......|::  |:|.:...|::.:..:..:|.:::...||||||
Zfish  1346 LELVIAGTA--------EIDLGDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTG 1402

  Fly  3069 SPRLPTGGFKAL---TPPLTIVRKTLDENQNPNDYLPSVMTCVNYLKLPDYSSREVMRQKLKVAA 3130
            :..:|..||.:|   ..|    |:...|.......||...||.|.|.||.|.|..::.:|:..|.
Zfish  1403 TSSIPYEGFASLRGSNGP----RRFCVEKWGKITSLPRAHTCFNRLDLPPYPSFSMLYEKMLTAV 1463

  Fly  3131 NEGS 3134
            .|.|
Zfish  1464 EETS 1467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442	15/88 (17%)
		HECTc	<2818..3138	CDD:294058	79/329 (24%)
hecw2b	XP_003197660.3	HECW_N	58..177	CDD:318711
		C2_NEDL1-like	198..334	CDD:176073	11/29 (38%)
		LGT	<491..633	CDD:320995	38/172 (22%)
		WW	708..737	CDD:306827	4/28 (14%)
		WW	887..919	CDD:197736	10/48 (21%)
		HECTc	1117..1470	CDD:238033	109/551 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000