Protein Alignment ctrip and trip12

DIOPT Version :10

• Sequence 1: NP_649496.3
• Gene: ctrip / 40596
• FlyBaseID: FBgn0260794
• Length: 3140
• Species: Drosophila melanogaster
• Sequence 2: NP_001136384.1
• Gene: trip12 / 100158539
• XenbaseID: XB-GENE-6071044
• Length: 2056
• Species: Xenopus tropicalis
• Alignment Length: 2756
• Identity: 1034/2756 - (37%)
• Similarity: 1391/2756 - (50%)
• Gaps: 780/2756 - (28%)

  Fly   447 NSAGSSYEEDTQIVAEEDEITTEEEVDDEDDDEIEEEDLSESEFAQQLIGELGGERQQPQRATN- 510
            |:||:..:|||                                         .|.|...::|.|
 Frog    19 NTAGAQPQEDT-----------------------------------------AGGRSNLEQAENK 42

  Fly   511 -----NAKKTKNNTPAVAAASTIKATTTATTSSGYQQRAAPHGQGAAPGAGGGGPRATRSSNSNS 570
                 .::|:...||.|      ::.||:..|.|:..:.........|     .|..|...|:..
 Frog    43 THSLPESRKSHFKTPKV------QSNTTSGPSKGHSSKRGCSSSNLLP-----NPEDTERINTTD 96

  Fly   571 SNNV-------VDYSIMP-HLTTVATTT---PHALTPQQHQQQRQPPQPPSHQQQQVHQQQQPPQ 624
            :...       |..|..| |..|.:.::   |.||   ||.:....|:.|:::.::....|:.|
 Frog    97 TQRPKKDHVRGVKRSASPDHSRTNSPSSAKKPKAL---QHPEPSSGPRRPNNKPKKRQGSQEQP- 157

  Fly   625 LLPTHQFAHLSSFVTPTAAAAAAAAAAHYPPASAAAAYFAQQQHHQHQHQHQQQHVQQAQAP--- 686
                                        :|.||..:...|          |.::...|..:|
 Frog   158 ----------------------------FPSASLPSTSKA----------HSRKGGSQGTSPLPK 184

  Fly   687 ------QPHYYHSSVAVLHQPPPHHFTSTGAGPPPALFQQQAPPQLTRYTPATATTAATFVPPQQ 745
                  .|....||.||:         ||||        :..||:|::....:||:|
 Frog   185 RKRTELSPCVKSSSAAVI---------STGA--------EDRPPKLSKLASKSATSA-------- 224

  Fly   746 QQVVYNPQQQQHSSLRRSSRGKTGSCVSSAAAAQQQQHHQQQQHSSAAAAVQQQLLPPPGTYQYQ 810
                    :...|::..||...:.|..|||.|             |.:||       |||
 Frog   225 --------KAGCSNITDSSSSASTSSSSSAVA-------------SVSAA-------PPG----- 256

  Fly   811 QVGGNTVVVAVRHQQQLQQQQQQQQQLALHHQHQQQQHQQQQQQHQQQQH-----QQQQRATLVQ 870
                      .|.:|...|.:.::.:.|.....::...:::|.:......     :...:.:|
 Frog   257 ----------ARVKQGKDQNKARRSRSASSPSPRRSSREKEQTKTSSSSKFDWAARFSPKVSL-- 309

  Fly   871 PGFLFSYRSNQPQQQQQPAQQIHQGPKVTHSSAASDALTYSLMAQQPPSGPP--HAGGQQITPGA 933
            |....|...:...:..:|      ||....:..|:...:....::.||:..|  ....:|.|.|
 Frog   310 PKTKLSLPGSSKTETSKP------GPSGLQAKLANLRKSTKKRSESPPAELPSLRRSTRQKTTG- 367

  Fly   934 NSANLSIVAAALSAARDVGGGSDGGGSAGGATPATGASASSVGNTSAVGASSSSNSSAGQAASSN 998
                        |.|.....|| |.|....|........:...|.....:|::......|.|:::
 Frog   368 ------------SCASTSRRGS-GLGKRAAAEARRQEKMADPDNQEGANSSAARTDETAQGAAAS 419

  Fly   999 SNNVTATGSGSAPGGGPTSTGTTSGTQHGSGSGAAAAVDSESDDSEVGRLQALLEARGLPPHLFG 1063
            |:...|.|.            ||||             :|||||||:||||||||||||||||||
 Frog   420 SSVAGAVGM------------TTSG-------------ESESDDSEMGRLQALLEARGLPPHLFG 459

  Fly  1064 ALGPRVTHILHRTIGNSSSSKANQLLQGLQSHDESQQLQAAIEMCQMLVMGNEDTLAGFPIKQVV 1128
            .||||::.:.|||||:.:||||.|||||||:.||||||||.|||||:||||||:||.|||:|.||
 Frog   460 PLGPRMSQLFHRTIGSGASSKAQQLLQGLQATDESQQLQAVIEMCQLLVMGNEETLGGFPVKSVV 524

  Fly  1129 PALIQLLRMEHNFDIMNNACRALAYMLEALPRSSGTVVEAVPVFLEKLQVIQCMDVAEQSLSALE 1193
            ||||.||:|||||||||:|||||.||:|||||||..||:|:||||||||||||:|||||:|:|||
 Frog   525 PALITLLQMEHNFDIMNHACRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQCIDVAEQALTALE 589

  Fly  1194 ILSRRHNKAILQANGISACLTYLDFFSIVAQRAALAIAANCCLNMHPEEFHFVAESLPLLARLLS 1258
            :|||||:||||||.|::.||.||:||||.|||.|||||||||.::.|:||||||:|||||.:.|:
 Frog   590 MLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAANCCQSISPDEFHFVADSLPLLTQRLT 654

  Fly  1259 QQDKKCIESVCSAFCRLVESFQHDGQRLQQIASPDLLKNCQQLLLVTPAILNTGTFTAVVRMLSL 1323
            .||||.:||.|..|.|||::|||:...|||:||.|||.|.||||:|||.||::|.|..||||.||
 Frog   655 HQDKKSVESTCLCFARLVDNFQHEENLLQQVASRDLLTNIQQLLVVTPPILSSGMFIMVVRMFSL 719

  Fly  1324 MCCSCPDLAISLLRNDIAATLLYLLTGNAEPAAASATHVELISRSPSELYELTCLIGELMPRLPL 1388
            ||.:||.||:.|::.:||.||.:||.|.:.  .:....::|:.|||.||||||.||.||||.||.
 Frog   720 MCSNCPTLAVQLMKQNIAETLHFLLCGASN--GSCLEQIDLVPRSPQELYELTSLICELMPCLPK 782

  Fly  1389 DGIFAVDSLLDRPTLNTQDQVHWQWRDDRGSWHNYSTIDSRLIEAANQSSEDEISLSTFGRTYTV 1453
            :||||||::|.:......|...||||||||.||.||.||||:||||:|..||||||||.||.||:
 Frog   783 EGIFAVDTMLKKGNAQNTDGAIWQWRDDRGLWHPYSRIDSRIIEAAHQVGEDEISLSTLGRVYTI 847

  Fly  1454 DFHAMQQINEDTGTTRPVQRRLNHNYVAPMSAGQDLTTTSAGSAAAGGASTSAAAAAASSNNNNN 1518
            ||::||||||||||.|.:||:.|     |::
 Frog   848 DFNSMQQINEDTGTARAIQRKPN-----PVA---------------------------------- 873

  Fly  1519 NNNNPPGNSVNLNQVKRRPSLDARIACLKEERGLAADFIKHIFNVLYEVYSSSAGPNVRYKCLRA 1583
             |.|..|:|    ::||.   |||...:||:..||..|||.:|.||||||||||||.||:|||||
 Frog   874 -NANTTGHS----ELKRD---DARAQLMKEDPELAKSFIKTLFGVLYEVYSSSAGPAVRHKCLRA 930

  Fly  1584 LLRMVYYATPELLRQVLKYQLVSSHIAGMLGSNDLRIVVGALQMAEILMRQLPDVFGTHFRREGV 1648
            :||::|:|..|||:.|||...||||||.||.|.||:|||||||||||||::|||:|..:||||||
 Frog   931 ILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDLKIVVGALQMAEILMQKLPDIFSVYFRREGV 995

  Fly  1649 IYQFTQLTDPNNPICANPSPKPLSATATPTANAGGSQSAPASANSLQVNPFFMDSAPGLSSASTT 1713
            ::|
 Frog   996 MHQ-------------------------------------------------------------- 998

  Fly  1714 PSSSKHQSYSVKSFSHAMNALTASAKGTPSGALDATSSSTTAGGYNYSSSAPSSSSGAPAAYFVT 1778
                      ||:.:.:...||:..|...:|:....|::|
 Frog   999 ----------VKNLAESEALLTSPPKVCTNGSGSLASTTT------------------------- 1028

  Fly  1779 QQGDPRQYVHFQQPAVPAPPPQQELLPSGVQQQGQQVPQVIYQPHHQQPAHLVLASTSSGAASSS 1843
                                                                  .||.||.||.:
 Frog  1029 ------------------------------------------------------ISTGSGTASGN 1039

  Fly  1844 SSSSSSSSASALQH-----------KMTDMLKRKAPPKRKSQSGGRAKSRQEDAAVAPAGSGPGG 1897
            |::...|  .:|||           :::|:||||..|||    |.|.               |..
 Frog  1040 SAADLGS--PSLQHRDDSLDLSPPGRLSDVLKRKRLPKR----GPRR---------------PKY 1083

  Fly  1898 APPSSSGSAMHELLSRATSLGSGNGGRSTPNSGGGSGSSKSRFNAGNSSNAGSSKSSFLASLNPA 1962
            :||.......::..|..|:                                 .|..||||||||.
 Frog  1084 SPPRDEDKVDNQAKSPTTT---------------------------------QSPKSFLASLNPK 1115

  Fly  1963 RWGRQTHQNHHHHHQQSQQQHHGLSKDSGNSNSTGSGSGAGLAYTVSQHGAGSGAGGLNAAAVAA 2027
            .|||.:.|:                    |||:......||::             ||..||...
 Frog  1116 TWGRLSTQS--------------------NSNNIEPARTAGVS-------------GLARAASKD 1147

  Fly  2028 SISKSISHANLLAAANRERARQWVREQAVDFVKRYTEQEAKRSKAASESGATQSGSSGVGLSSTG 2092
            :||.           ||||.|.|::|||..||:||...|                      :..|
 Frog  1148 TISN-----------NRERIRGWIKEQAHKFVERYFSSE----------------------NMDG 1179

  Fly  2093 NTPLSTAGSTNVLERLSSILFKLNGSYHDCLDALLELKTILLESDISPFEVNHSGLIKAMLNYMT 2157
            :.|     :.|||:||.:...:||......::.|:|:::|:.|||:|.||:.|||.:|.:|.|:|
 Frog  1180 SNP-----ALNVLQRLCNATEQLNLQVDGGVECLVEIRSIVSESDVSSFEIQHSGFVKQLLLYLT 1239

  Fly  2158 SET--GLVERDARLRSFMHVFAGLPL---EPLLQNVGQMPTIEPIAFGAFVAKLNGCVTQLEQFP 2217
            |::  .:|.||.||:.|:|||.|.||   |||    .::...|.....|.|.|:|.|::|:||||
 Frog  1240 SKSDKDIVSRDIRLKRFLHVFFGTPLPGEEPL----AKLDPTENRHLLALVHKMNNCLSQMEQFP 1300

  Fly  2218 VKVHDFPAGPG-GRSNQSALRFFNTHQLKCNLQRHPQCNNLRQWKGGTVKIDPLAMVQAIERYLV 2281
            |||||||:|.| |.....||:|||||||||.|||||.|.|::|||||.|||||||:|||||||||
 Frog  1301 VKVHDFPSGNGTGSRGSQALKFFNTHQLKCQLQRHPDCTNVKQWKGGPVKIDPLALVQAIERYLV 1365

  Fly  2282 VRGYGGIR---ADSDDD-SEEDMDDNVAAVVLSQASFRHKLQFTIGDHVLPYNMTVYQAVKQFSP 2342
            |||||.:|   .||||| |:|::|:::||..|:..:.||:|||.||||:|||||||||||:|:|.
 Frog  1366 VRGYGRVREDDEDSDDDGSDEEIDESLAAQFLNSGNVRHRLQFYIGDHLLPYNMTVYQAVRQYSI 1430

  Fly  2343 LVSEQPETDNESETLLGNASIWVQQHTIHYRPVEEEV-----TSGAAAGAASSSSSCSSGVQKQQ 2402
            ...|:.|:.::....||.|.||.:.|||.|:||.||.     |.|...|.|.::.:
 Frog  1431 QTEEERESTDDESNPLGRAGIWTKTHTIWYKPVREEEESAKDTVGGKRGRAQTAPT--------- 1486

  Fly  2403 SSSSSASSCVNATSSCSSSSGVASGGGSLTKKAHKSSSKFMRKKTELWH--EGIAPVVISALKPF 2465
                                              |:|.:..:|..||||  :|:.|.:::.|:.:
 Frog  1487 ----------------------------------KTSPRNSKKHDELWHGKDGVCPRILNPLEVY 1517

  Fly  2466 LSSSLPADVVTVQDASLDALCMLRVIHALNRHWDHLYGCVVRQNIIPQSDFIHPKIMAKANRQLQ 2530
            |.|. |.:.:|..|.|||.:.:|||:||::|:|.:||...|.:.|||.|:|.:.|:.||||||||
 Frog  1518 LISG-PPENITFDDPSLDVVILLRVLHAISRYWYYLYDNAVCKEIIPTSEFNNSKLTAKANRQLQ 1581

  Fly  2531 DPLVIMTGNLPQWLPQIGMACPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDLNAAESSE-RV 2594
            |||||||||:|.||.::|.:|||.|||:||.:|||.|:||||||:||||||.|::|.::|.: ||
 Frog  1582 DPLVIMTGNIPTWLTELGKSCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSRV 1646

  Fly  2595 APRLDRRKRAISRTEILKQAEHILQDFGHSKALLEIQYENEVGTGLGPTLEFYALVSAELQRTDL 2659
            ||||||:||.::|.::|||||.::||.|.|:|:||||||||||||||||||||||||.||||.||
 Frog  1647 APRLDRKKRTVNREDLLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTLEFYALVSQELQRADL 1711

  Fly  2660 GLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQH 2724
            |||.|.:
 Frog  1712 GLWRGEE---------------------------------------------------------- 1718

  Fly  2725 QHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPSSTTTA 2789
                                                                 ..:.||..:...
 Frog  1719 -----------------------------------------------------VTLPNPKGSQEG 1730

  Fly  2790 TTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKAKFKFLGKFMAKAVMD 2854
                                 |.|:|.:.|||.||.|:::|...:.|.|.||:||||.||||:||
 Frog  1731 ---------------------TKYIHNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMD 1774

  Fly  2855 SRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDAMEKTE 2919
            .|::|:|..||||:|::.:|.|:...||:.:.|.|..::..|:|:|||::.:..|..........
 Frog  1775 FRLVDIPLGLPFYKWMLRQESSLATHDLVNIDPVVAKSVYHLEDIVRQKKRLEQDKAQTKESLQF 1839

  Fly  2920 KIEQLDLDGCPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFEA 2984
            .:|.|:::||.:.||||||.|||..||||.:||:|.|||:|||..|:.||.||.|.|||.:|.::
 Frog  1840 ALESLNMNGCSVEDLGLDFTLPGFPNIELKKGGKDVPVTIHNLEDYVRLVIYWALNEGVSRQLDS 1904

  Fly  2985 LREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFHQDSQAIQYLYE 3049
            .|:||:||||:..|:.||||||:.:.|||.::.    |::|.|.|.||.|||:..||:|:::|:|
 Frog  1905 FRDGFESVFPLNHLQYFYPEELDQLLCGSRADP----WDVKTLMECCRPDHGYTHDSRAVKFLFE 1965

  Fly  3050 ILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSVMTCVNYLKLP 3114
            ||:|:::::||.||||||||||||.|||::|.|||||||||.:..:||:|:||||||||||||||
 Frog  1966 ILSSFDKEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFEATENPDDFLPSVMTCVNYLKLP 2030

  Fly  3115 DYSSREVMRQKLKVAANEGSMSFHLS 3140
            ||||.:.||:||.:||.||..|||||
 Frog  2031 DYSSIDNMREKLLMAAREGQQSFHLS 2056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_649496.3	Extensin_2	<688..731	CDD:252669	12/42 (29%)
		SRP1	1087..>1312	CDD:227396	164/224 (73%)
		WWE	1409..1481	CDD:128922	49/71 (69%)
		HECTc	<2818..3138	CDD:474882	168/319 (53%)
trip12	NP_001136384.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..440		113/629 (18%)
		PHA03307	84..>462	CDD:223039	115/539 (21%)
		SRP1	483..>708	CDD:227396	164/224 (73%)
		WWE	804..867	CDD:460715	46/62 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1027..1147		49/285 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1465..1500		10/77 (13%)
		K-box. /evidence=ECO:0000250	1560..1634		51/73 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1632..1651		9/18 (50%)
		HECTc	1654..2054	CDD:238033	220/535 (41%)