DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ctrip and hecw2a

DIOPT Version :9

Sequence 1:	NP_001189170.1	Gene:	ctrip / 40596	FlyBaseID:	FBgn0260794	Length:	3140	Species:	Drosophila melanogaster
Sequence 2:	XP_009302976.1	Gene:	hecw2a / 100150269	ZFINID:	ZDB-GENE-090311-22	Length:	1475	Species:	Danio rerio

Alignment Length:	1855	Identity:	352/1855 - (18%)
Similarity:	542/1855 - (29%)	Gaps:	689/1855 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1571 SAG----PNVRY----KCLRALLRM--VYYATPELLRQVLKYQLVSSHIAGMLGSNDLRIVVGAL 1625
            |||    ||||:    :.||:|...  ...|...|||......||||.....|.::.|...:...
Zfish    14 SAGRRRSPNVRHTLSPENLRSLAERGGAEQAGVGLLRANSDTDLVSSQGRSSLTASTLEFTLCRG 78

  Fly  1626 QMAEILMRQLPDVFGTHFRREGVIYQFTQLTDPNNPICANPSPKPLSATATPTANAGGSQSAPAS 1690
            |...|......:|..|.:..   :|...:....|...|.|             ....|:|....
Zfish    79 QNLVISWDIKEEVDATDWIG---LYHIDETCPSNVWDCKN-------------RGVNGTQCGQI- 126

  Fly  1691 ANSLQVNPFFMDSAP--------GLSSA--STTPS-SSKHQSYSVKSFSHAMNALTASAKGTPSG 1744
            ...|:|.|:|::|..        |:|.|  :|||. :.|:...||........|..:|.|
Zfish   127 VWRLEVGPYFLESETRICFKYYHGVSGALRATTPCITVKNPRASVDGQGEGQQASDSSRK----- 186

  Fly  1745 ALDATSSSTTAGG-----------YNYSSSAPSSSSGAPAAYFVTQQ---------------GDP 1783
            .:..|.|...|.|           |...|..|...|..|......|:               |:.
Zfish   187 LVSFTLSDIRAVGLKKGMFFNPDPYLKMSIHPGKRSCFPTFSHHGQERRSGITTNTTNPVWHGEK 251

  Fly  1784 RQYVHFQQPAVPAPPPQQELLPSGVQQQGQQVPQVI--YQPHHQQPAHLVLASTSSGAASSSSSS 1846
            ..:|..          ..::|...|:.:..:...:|  :......|..|:|...|:|..|.|.|
Zfish   252 HTFVAL----------MTDVLVIEVKDKFAKSRPIIKRFLGQLNIPVQLLLERHSTGNQSLSFS- 305

  Fly  1847 SSSSSASALQHKMTDMLKRKAPPKRKSQSGGRAKSRQEDAAVAPAGSGP---------GGAP--P 1900
                            |.|:.|....|   |:...:.:..::.|....|         .|||  |
Zfish   306 ----------------LCRRLPTDHVS---GQMHFKVDVTSMGPDDVSPETILGAAALNGAPGTP 351

  Fly  1901 SSSGSAMHEL-LSRA-----TSLGSG-NG-GRSTPNSG----GGS-------------GSSKSRF 1940
            |......|.| :|.|     .||||. || |.|.|:..    ||:             ||...:.
Zfish   352 SDDEELPHPLPISSAGPSPTASLGSNRNGEGSSIPSPDTEIYGGTLDDEAPSSPDLLQGSFSEQL 416

  Fly  1941 NAGNSSNAGSSKSSFLASLNPARWGRQTHQNHHHHHQQSQQQHHGLSKDSGNSNST----GSGSG 2001
            :|..:......:.  |.:.:|     :...:...|.:.|...|....:|...|.:|    .:.:|
Zfish   417 DAIEAPKGPGDRP--LGAASP-----KLRSSFPTHTRLSAMLHIDSDEDEDRSAATEATLSTFNG 474

  Fly  2002 AGLAYTVSQHGAGSGA---GG----------------LNAA--------AVAASISKSISHANLL 2039
            ...:|......|..||   ||                |||.        .|.:|::..:..|:|:
Zfish   475 IPRSYQTPPKAAARGAVFDGGIEEPSEEAGLESEVETLNAGEEVPPEPEVVPSSVAPEVETASLM 539

  Fly  2040 AAANRERARQWVREQAVDFVKRYTEQEAKRSKAASESGATQSGSS-------------------- 2084
                 ||..:..||..|       |:|.:...|.||..||:...|
Zfish   540 -----ERQEEQGREVEV-------EEEEEEGLARSEELATEVDISSMASDCCPGPASASQEAEQG 592

  Fly  2085 --------GVGLSSTGNTPLSTAGS------TNVLERLSSILFKLNGSYHDCLDAL--------- 2126
                    |..||....|....|.:      ||..||.:...........:|.|..
Zfish   593 AEAAIDPGGEDLSDDPPTTYEVAETAEETHLTNEPEREAPKPEPPTNEEEECEDVTEDTMSRRWS 657

  Fly  2127 LELKTILLESDISPFEVNHSGLIKAMLNYMTSETGLVERDARLRSFMHVFAGLPLEPLLQNVGQM 2191
            ||....:.:.|......:..|      ..:.|||.:.|.::.|        |:|.....|.|..:
Zfish   658 LEATAGVSQEDEDELIPSGDG------ESVDSETFVTETESEL--------GVPQVNGDQRVNSL 708

  Fly  2192 PTIEPIAFGAFVAKLNGCVTQLEQFPVKVH-----DFPAGPG--GRSNQSALRFFNTHQLKCNLQ 2249
            |::..                      .:|     |.|..|.  .|.:.....||..|
Zfish   709 PSVRQ----------------------DIHRYQRVDEPLPPNWEARIDSHGRIFFVDH------- 744

  Fly  2250 RHPQCNNLRQW---------KGGTVKIDPLAMVQAIERYLVVRGYGGIRADSDDDSEEDMDDNVA 2305
                .|....|         :|.|.....|.|.|...||..:|     |..:.:.|||
Zfish   745 ----VNRTTTWQRPTGPPAPQGLTRSSSILQMEQLNRRYQSIR-----RTMTSERSEE------- 793

  Fly  2306 AVVLSQASFRHKLQFTIGDHVLPYNMTVYQAVKQFSPLVSEQP--ETDNESETLLGNASIWVQQH 2368
                                                |.|.:.|  |||..::::
Zfish   794 ------------------------------------PRVEDPPADETDVLAQSI----------- 811

  Fly  2369 TIHYRPVEEEVTSGAAAGAASSSSSCSSGVQKQQSSSSSASSCVNATSSCSSSSGVASGGGSL-- 2431
                    .|.......|.:||.|..:..:|...:...|:....:...|..|:..:.:....|
Zfish   812 --------SEYRRDGIIGQSSSRSRLALLLQSPGAKFLSSPDFFSVLHSNPSAYRMFTSNTCLKH 868

  Fly  2432 -TKKAHKSSSKFMR----------------KKTEL---W-----HEGIAPVVISALK--PFLSSS 2469
             ..|..:.:..|.|                |:.||   |     |.|.|..|....:  .|:...
Zfish   869 MISKVRRDAQHFERYQHNRDLVNFLNLFSNKQLELPRGWEMKHDHTGKAFFVDHNCRATTFIDPR 933

  Fly  2470 LPADVVTVQDASLDALCMLRVIHALNRHWDHLYGCVVRQNIIPQSDFIHPKIMAKANR--QLQDP 2532
            ||     :|::....|...|  ..|:|...|..|.|...:..|.     |.:..:::|  |.||.
Zfish   934 LP-----LQNSRSSGLLAHR--QHLSRQRSHSAGEVGDDSRSPS-----PPVQGRSSRNSQYQDL 986

  Fly  2533 L-VIMTGNLPQWLPQIGMACPFLF-------PFETR-HLLFYATSFDRDRALQRL--LDTTPDL- 2585
            : |.....:..:|.|     |.:|       |...| |.|.....|.|:.....|  |.:..||
Zfish   987 VPVAYNDKIVAFLRQ-----PNIFEILQERQPELVRNHSLREKVQFIRNEGATGLTRLSSDADLV 1046

  Fly  2586 -------------------------NAAESSERVAPRLDRR-----KRAI--------------- 2605
                                     :|:..|....||.:.|     ||..
Zfish  1047 MLLSLFEEEVMSYVPPNALLLSSYCHASPQSSPGTPRANARAPAPYKRDFEAKLRNFYRKMETKG 1111

  Fly  2606 -----SRTEILKQAEHILQD-FGH---------SKALLEIQYENEVGTGL-GPTLEFYALVSAEL 2654
                 .:.:::.:.:|:|:| |..         .::.|.:.:..|.|... ||:.||:.|||.||
Zfish  1112 YGQGPGKVKLIIRRDHLLEDAFNQIMCYSRKDLQRSRLYVSFVGEEGLDYSGPSREFFFLVSREL 1176

  Fly  2655 QRTDLGLWNGSDSYKQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTT 2719
            .....||:    .|..|....|.:
Zfish  1177 FNPYYGLF----EYSANDTYTVQI----------------------------------------- 1196

  Fly  2720 TAQQHQHPPTRSSSRSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPS 2784
                                                                  |...|.:||
Zfish  1197 ------------------------------------------------------SPMSAFVDN-- 1205

  Fly  2785 STTTATTVVQHNTTTNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKAKFKFLGKFMA 2849
                      |:..                                          |:|.|:.:.
Zfish  1206 ----------HHEW------------------------------------------FRFSGRILG 1218

  Fly  2850 KAVMDSRMLDLPFSLPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDA 2914
            .|::...:||..|:.|||:.|:  .....|:||..:..|...:|..::|
Zfish  1219 LALIHQYLLDAFFTRPFYKGLL--RIPCDLSDLEFLDEEFHQSLQWMKD---------------- 1265

  Fly  2915 MEKTEKIEQLDLDGCPIADLGLDFVLPGHANI-------ELCRGGRDTPVTVHNLHQYISLVTYW 2972
                ..||.:           ||.....:..:       ||..||....|:..|..:||..:..|
Zfish  1266 ----NDIEDM-----------LDLTFTVNEEVFGQITERELKPGGSGIAVSDKNKKEYIERMVKW 1315

  Fly  2973 FLIEGVQKQFEALREGFDSVFPIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGF 3037
            .:..||.:|.|:|..||..|..::.:.:|...|||.|..|: :|...|.|     :.:.....|:
Zfish  1316 RIERGVAQQTESLVRGFYEVVDVRLVSVFDARELELVIAGT-AEIDLSDW-----RNNTEYRGGY 1374

  Fly  3038 HQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKAL---TPPLTIVRKTLDENQNPND 3099
            |.:...|::.:..:..:|.:::...||||||:..:|..||.:|   ..|    |:...|......
Zfish  1375 HDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGP----RRFCVEKWGKVT 1435

  Fly  3100 YLPSVMTCVNYLKLPDYSSREVMRQKLKVAANEGS 3134
            .||...||.|.|.||.|.|..::.:|:..|..|.|
Zfish  1436 SLPRAHTCFNRLDLPPYPSFSMLYEKMVTAVEETS 1470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctrip	NP_001189170.1	Extensin_2	<688..731	CDD:252669
		WWE	1409..1481	CDD:128922
		FAM199X	<1985..2074	CDD:292442	25/119 (21%)
		HECTc	<2818..3138	CDD:294058	78/327 (24%)
hecw2a	XP_009302976.1	HECW_N	50..169	CDD:318711	29/135 (21%)
		C2_NEDL1-like	188..323	CDD:176073	28/164 (17%)
		WW	724..756	CDD:197736	8/42 (19%)
		WW	903..934	CDD:197736	7/30 (23%)
		HECTc	1120..1473	CDD:238033	104/547 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900