DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17387 and Ccdc39

DIOPT Version :9

Sequence 1:	NP_649495.1	Gene:	CG17387 / 40595	FlyBaseID:	FBgn0037276	Length:	967	Species:	Drosophila melanogaster
Sequence 2:	NP_080498.1	Gene:	Ccdc39 / 51938	MGIID:	1289263	Length:	937	Species:	Mus musculus

Alignment Length:	972	Identity:	222/972 - (22%)
Similarity:	460/972 - (47%)	Gaps:	90/972 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EAMASVGWAVDSDIPMASAENLAILKELTALRALKLELQQHMNSLDEREMAVERHTRNIEGTIQQ 82
            |.::.:.|.....||:|:.||..:..:|..||..|..||..::..:||..::..|.:|:......
Mouse     4 EFLSELHWEDGFAIPVANQENKILEDQLAKLREEKSNLQDQLHDYEERINSMTSHLKNVNQEFLF 68

  Fly    83 NLTLYSSLKDDVIKEAHNVQLVILERNKIKEDLRKNNKELEEYTEYVKVTERKICQSKREIDELT 147
            ..:||.:.:.::..|.|...:...|..::|.:.:...||:....|.....|..|.::.:::|:|.
Mouse    69 TQSLYKARESEIESEEHFKAIAERELGRVKNETQLLEKEMAIIRERKSQMENNIFKTTQKLDDLK 133

  Fly   148 SRIKSAKTTLVEWTEAMEDGNKGYQLIEKYYLDDQQKARELNIKRQLLQADIDKRRKQVVLLYDE 212
            .::...:..|..|.|.....:.....::||...|..|.|.|.::.:.|..:.:::||.:.....|
Mouse   134 CQMNWDQQALEAWLEESAHKDSDSLTLQKYSQQDDNKIRALTLQLEKLTMEYNEKRKLLDSELTE 198

  Fly   213 QMTLEKNLERTACLYRSAHAERRQMVETWKSAVNQMTQREHDIQRSEIECAELAQKAQQTAQTYK 277
            .::.:..|::.|..:|..|.||:::::.|::.:.||.:|:.:|....:..:.:.|:|::.....|
Mouse   199 TLSAQLELDKAAQDFRKIHLERQELIQQWENTIEQMQRRDQEIDNCALALSRIKQEAREKEGVVK 263

  Fly   278 E----YDNQLTEVIENNRQVELAIESLNEESSDMK----NQIQILIDATLLKEREIDGLRRELEN 334
            |    .:|::...||..|::.:|...:::...|.:    |:.|       ||: |:|.|:..|..
Mouse   264 EKIKFLENEVENNIEYERKISVAERKVSKCRMDYQRHEGNRSQ-------LKD-ELDTLKTTLNR 320

  Fly   335 LSNRVHLQRMDNRSQMKKR--DEKAKELENFASVMEKVNARLKSVQNKALNAEQRLQILEEMMQA 397
            .|:.:...| .|.|::||.  ||..: |:......|.|..:||.:..|.|:.|::...:|:|::.
Mouse   321 TSSDLQALR-KNISKVKKDIFDETLR-LQKLKHHNEVVKHKLKMITEKTLSIEEKATNMEDMLKE 383

  Fly   398 EETALRNLDKEQEKVNEMLYRTQRQVIELQDE---EKVLKVQNDSLNSNLAAINRNQQQVNNELK 459
            ||..|:.::.:...|.::|:   ::|.|||:|   ||.|..:.:...|:|..:|:...:::.|..
Mouse   384 EEKGLKEVEVQLGIVKDVLF---KKVQELQNEIAKEKALVSEIEGTRSSLKHLNKQLHKLDFETL 445

  Fly   460 RQTEIHYSLSFKCLEAERRLAEIKGLADDPEVEATNMARLNTLEQEYEKLQRLIATTEAQNKKLN 524
            :|.||.||..|...:.|||::.:||..:..|.:|.. |::..|::..::.:..::..|:|.|||:
Mouse   446 KQQEIMYSQDFYIQQVERRMSRLKGEINSEEKQALE-AKILELKKTMDEKKSTLSLLESQIKKLH 509

  Fly   525 YNMNNLVVQYNADEKELEMVRFKIKEAQVYCEGTVKRLRQIRYENSELIVDLNMVKMRCSDLEVG 589
            .::..:......:..|.|.:..||.|..::.:.:.|.|.:.:....:::::.|::|::.......
Mouse   510 NDLYFIKKSNGKNNDEKESLMNKISELNLFIDRSEKELSKAKAVKEDMMIEDNLLKLQVKRAREL 574

  Fly   590 IGGCEQGTYDLEQHRLAFRRAIKDRTVELRSQEDVLLLKKKHLNEELSTLRADLGERKKQIEAMK 654
            :....:....||:.:....:.:::|..|::..:.:|..:.:.:.::..|:.::..||..:|:.:|
Mouse   575 LYSKAEEVLSLEKRKQQLGKDMEERAEEIKVHKAMLTSQIRCVEQQRKTMSSEFHERLSKIDKLK 639

  Fly   655 ARFELTAQLLGKNEDGSIMTSTQLKVVSAQERQMLADEGDALNKKVLKAEKEVVALENTLRQFDK 719
            .|:|:...::...|.....|.:...:.:|||::.|..|||:|:.|:.|||||:.||:|||:..:.
Mouse   640 NRYEILTVVMLPPEGEEEKTQSYYVIKAAQEKEELQREGDSLDAKINKAEKEIYALQNTLQVLNS 704

  Fly   720 SNDNYRKTFRSVDENSKDRERAELELKELEAAYCRELEKLKVLRCKAQHYQQKHAAQRAEEEDLI 784
            .|.||:::|:.|..:| |....:::|:|.:             |...:.|:.|....|..:||:.
Mouse   705 CNSNYKQSFKKVTPSS-DEYALKIQLEEQK-------------RTADERYRCKQRQIRELQEDIQ 755

  Fly   785 SK----------IEKAKASRAEHSAVLEKIERELDDQRMKLDRANREIRTQLREIKARPFSEEYL 839
            |.          ...||....|...:..::.:|.::|:.||.|..::.....|||:....::...
Mouse   756 SMENTFEVIGHLANNAKEKLTEKQTLAFQLRKETEEQKPKLQRITKQCGRLRREIRILKQTDNET 820

  Fly   840 AQFERDLSLQELEARNTKALNMITDLANSDESGTDIIGILLRKGIKLPMHLKRTCSRVSWNSSSS 904
            .: |:|:.|:|:...:.....|:.:...:.|..........:.|::||              ::.
Mouse   821 LE-EQDIQLREIIQFHKDIDQMLVNAMENAEIHAIFKTYFEQNGLELP--------------TAR 870

  Fly   905 GKSSQGQDTASYLNVKGKKFSCDGASARSSVSDMSSLKDDT--SSTTSHSGLSIISLELPLP 964
            |.||:                  .:|..||:|...||:|.|  |..|:    .:|.|..|.|
Mouse   871 GPSSR------------------SSSQSSSLSSFRSLEDVTLQSPPTA----KVIQLRFPEP 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17387	NP_649495.1	Smc	200..>853	CDD:224117	160/675 (24%)
Ccdc39	NP_080498.1	Smc	22..704	CDD:224117	164/695 (24%)
Ccdc39	NP_080498.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	866..937		19/81 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849327
Domainoid	1	1.000	276	1.000	Domainoid score	I1722
eggNOG	1	0.900	-	-		E1_2C32D
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12149
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2919
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006077
OrthoInspector	1	1.000	-	-		oto93395
orthoMCL	1	0.900	-	-		OOG6_103837
Panther	1	1.100	-	-	LDO	PTHR18962
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5539
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780