DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17387 and CCDC39

DIOPT Version :9

Sequence 1:	NP_649495.1	Gene:	CG17387 / 40595	FlyBaseID:	FBgn0037276	Length:	967	Species:	Drosophila melanogaster
Sequence 2:	NP_852091.1	Gene:	CCDC39 / 339829	HGNCID:	25244	Length:	941	Species:	Homo sapiens

Alignment Length:	965	Identity:	231/965 - (23%)
Similarity:	465/965 - (48%)	Gaps:	76/965 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EAMASVGWAVDSDIPMASAENLAILKELTALRALKLELQQHMNSLDEREMAVERHTRNIEGTIQQ 82
            |.:|.:.|.....||:|:.||..:..:|:.|:..:..||..:...:||..::..|.:|::..:..
Human     4 EFLAELHWEDGFAIPVANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSI 68

  Fly    83 NLTLYSSLKDDVIKEAHNVQLVILERNKIKEDLRKNNKELEEYTEYVKVTERKICQSKREIDELT 147
            ..:|..:.:.:...|.|...:...|..::|:::::...|:....|.....|..|.::.:::|.|.
Human    69 TQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLK 133

  Fly   148 SRIKSAKTTLVEWTEAMEDGNKGYQLIEKYYLDDQQKARELNIKRQLLQADIDKRRKQVVLLYDE 212
            .::...:..|..|.|.....:.....::||...|..|.|.|.::.:.|..:.:::||.:.....|
Human   134 CQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTE 198

  Fly   213 QMTLEKNLERTACLYRSAHAERRQMVETWKSAVNQMTQREHDIQRSEIECAELAQKAQQTAQTYK 277
            .::.:..|::.|..:|..|.||:::::.|::.:.||.:|:.||....:|.|.:.|:.::.....|
Human   199 TISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVK 263

  Fly   278 EYDNQLTEVIENNRQVELAIESLNEESSDMKNQIQILIDATLLKEREIDGLRRELENLSNRVHLQ 342
            |....|...|.||.:.|..|...:.:....:...|....:.:..:.|:|.|:..:...|:.:...
Human   264 EKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEAL 328

  Fly   343 RMDNRSQMKKR-DEKAKELENFASVMEKVNARLKSVQNKALNAEQRLQILEEMMQAEETALRNLD 406
            | .|.|::||. .|:...|:...:..|.:..:||.:..|.::.|::...||:|::.||..::.:|
Human   329 R-KNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVD 392

  Fly   407 KEQEKVNEMLYRTQRQVIELQDE---EKVLKVQNDSLNSNLAAINRNQQQVNNELKRQTEIHYSL 468
            .:...:..:|::..:   |||.|   ||.:..:.:...|:|..:|...|:::.|..:|.||.||.
Human   393 VQLNLIKGVLFKKAQ---ELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQ 454

  Fly   469 SFKCLEAERRLAEIKGLADDPEVEATNMARLNTLEQEYEKLQRLIATTEAQNKKLNYNMNNLVVQ 533
            .|...:.|||::.:||..:..|.:|.. |::..|.:..|:.:......|.|.|||:.::..:...
Human   455 DFHIQQVERRMSRLKGEINSEEKQALE-AKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKA 518

  Fly   534 Y--NADEKELEMVRFKIKEAQVYCEGTVKRLRQIRYENSELIVDLNMVKMRCSDLEVGIGGCEQG 596
            :  |:|||:..|.  ||.|..::.:.:.|.|.:.:....:|:::.|::|:........:....:.
Human   519 HSKNSDEKQSLMT--KINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEE 581

  Fly   597 TYDLEQHRLAFRRAIKDRTVELRSQEDVLLLKKKHLNEELSTLRADLGERKKQIEAMKARFELTA 661
            ...||:.:.....|:::||.|::..:.:|..:.:::::|...:..:..||..:||.:|.|:|:..
Human   582 VLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILT 646

  Fly   662 QLLGKNEDGSIMTSTQLKVVSAQERQMLADEGDALNKKVLKAEKEVVALENTLRQFDKSNDNYRK 726
            .::...|.....|.....:.:|||::.|..|||.|:.|:.|||||:.||||||:..:..|:||::
Human   647 VVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQ 711

  Fly   727 TFRSVDENSKDRERAELELKELEAAYCRELEKLKVLRCKAQHYQQKHAAQRAEEEDL------IS 785
            :|:.|..:|.     |.|||       .:||:.|  |...:.|:.|....|..:||:      :.
Human   712 SFKKVTPSSD-----EYELK-------IQLEEQK--RAVDEKYRYKQRQIRELQEDIQSMENTLD 762

  Fly   786 KIE----KAKASRAEHSAVLEKIERELDDQRMKLDRANREIRTQLREIKARPFSEEYLAQFERDL 846
            .||    ..|...:|..|...::.:|.::|:.||:|..::.....:||:....:::...: |:|:
Human   763 VIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETME-EQDI 826

  Fly   847 SLQELEARNTKALNMITDLANSDESGTDIIGIL----LRKGIKLPMHLKRTCSRVSWNSSSSGKS 907
            .|:|::..:.....|:.|:.   |..|:|..||    .:.|::||             ::|:..|
Human   827 KLREMKQFHKVIDEMLVDII---EENTEIRIILQTYFQQSGLELP-------------TASTKGS 875

  Fly   908 SQGQDTASYLNVKGKKFSCDGASARSSVSDMSSLKDDTSSTTSHSGLSIISLELP 962
            .|...:.|:.::          |||||.|        ||::||.|.:.::.|:.|
Human   876 RQSSRSPSHTSL----------SARSSRS--------TSTSTSQSSIKVLELKFP 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17387	NP_649495.1	Smc	200..>853	CDD:224117	167/668 (25%)
CCDC39	NP_852091.1	Smc	22..848	CDD:224117	200/850 (24%)
CCDC39	NP_852091.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	868..941		18/76 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158947
Domainoid	1	1.000	290	1.000	Domainoid score	I1554
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12149
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2804
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177902at33208
OrthoFinder	1	1.000	-	-		FOG0006077
OrthoInspector	1	1.000	-	-		oto89822
orthoMCL	1	0.900	-	-		OOG6_103837
Panther	1	1.100	-	-	LDO	PTHR18962
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5539
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.930