DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17387 and Ccdc39

DIOPT Version :9

Sequence 1:	NP_649495.1	Gene:	CG17387 / 40595	FlyBaseID:	FBgn0037276	Length:	967	Species:	Drosophila melanogaster
Sequence 2:	XP_017446344.1	Gene:	Ccdc39 / 310315	RGDID:	1306277	Length:	934	Species:	Rattus norvegicus

Alignment Length:	975	Identity:	223/975 - (22%)
Similarity:	466/975 - (47%)	Gaps:	97/975 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EAMASVGWAVDSDIPMASAENLAILKELTALRALKLELQQHMNSLDEREMAVERHTRNIEGTIQQ 82
            |.::.:.|.....||:|:.||..:..:|..|...|..||..:...::|..::..|.:|:......
  Rat     4 EFLSELHWEDGFAIPVANQENKILEDQLAKLHKEKSNLQDQLRDYEDRINSMSSHLKNVNQEFLF 68

  Fly    83 NLTLYSSLKDDVIKEAHNVQLVILERNKIKEDLRKNNKELEEYTEYVKVTERKICQSKREIDELT 147
            ..:||.:.:.::..|.|...:...|..::|:::::..||:....|.....|..|.::.:::|.|.
  Rat    69 TQSLYKARECEIESEEHFKAIAERELGRVKDEIQQLEKEMAIILERKNDKENAIFKATQKLDGLK 133

  Fly   148 SRIKSAKTTLVEWTEAMEDGNKGYQLIEKYYLDDQQKARELNIKRQLLQADIDKRRKQVVLLYDE 212
            .::...:..|..|.|.....:.....::||...|..|.|.|.:|.:.|..:.:::||.:.....|
  Rat   134 CQMNWDQQALEAWLEESAHKDSDSLTLQKYSQQDNNKIRALTLKLEKLTMECNEKRKLLDNELTE 198

  Fly   213 QMTLEKNLERTACLYRSAHAERRQMVETWKSAVNQMTQREHDIQRSEIECAELAQKAQQTAQTYK 277
            .::.:..|::.|..:|..|.||:::::.|::.:.||.:|:.:|....:..|.:.|:|::.....:
  Rat   199 TLSAQLELDKAAQDFRKIHVERQELIQQWENTIEQMQRRDQEIDNCALALARIKQEAREKEGVVR 263

  Fly   278 E----YDNQLTEVIENNRQVELA--------IESLNEESSDMKNQIQILIDATLLKEREIDGLRR 330
            |    .:|::...:|..|::.:|        :|...:|::  :||         ||: |:|.|:.
  Rat   264 EKIKFLENEVGNNVEYERRISIAERKVSKCRMEYQRQEAN--RNQ---------LKD-ELDTLKT 316

  Fly   331 ELENLSNRVHLQRMDNRSQMKK--RDEKAKELENFASVMEKVNARLKSVQNKALNAEQRLQILEE 393
            .|...|:.:...| .|.|::||  .||..: |:......|.|..:||.:..|.::.|::...:|:
  Rat   317 TLNRTSSDLEALR-KNISKVKKDILDETGR-LQKLKHHNEIVKHKLKMITEKTISIEEKATNMED 379

  Fly   394 MMQAEETALRNLDKEQEKVNEMLYRTQRQVIELQD---EEKVLKVQNDSLNSNLAAINRNQQQVN 455
            |::.||..|:.::.:...|..:|:   ::|.|||.   :||.|..:.:...|:|..:|:...:::
  Rat   380 MLKEEEKNLKEVEVQLNIVKGVLF---KKVQELQSAITKEKALGSEIEGTRSSLKHLNQRLHKLD 441

  Fly   456 NELKRQTEIHYSLSFKCLEAERRLAEIKGLADDPEVEATNMARLNTLEQEYEKLQRLIATTEAQN 520
            .|..:|.||.||..|...:.|||::.:||..:..|.:|..: ::..|.:..|:.:..::..|.|.
  Rat   442 FETLKQQEIMYSQDFYIQQVERRMSRLKGEINSEEKQALEV-KIVELRKTMEERKSTLSLLEEQI 505

  Fly   521 KKLNYNMNNLVVQYNADEKELEMVRFKIKEAQVYCEGTVKRLRQIRYENSELIVDLNMVKMRCSD 585
            |||:.::..:......::.|.|.:..||.|..::.:.:.|.|.:.:....:|:::.|::|::...
  Rat   506 KKLHNDLYFIKKSNGKNKDEKESLMNKIGELHLFVDRSEKELNKAKAVKEDLMIEDNLLKLQVKR 570

  Fly   586 LEVGIGGCEQGTYDLEQHRLAFRRAIKDRTVELRSQEDVLLLKKKHLNEELSTLRADLGERKKQI 650
            ....:....:....||:.:.....|:::|..|::..:.:|..:.::::::..|:.::..||..:|
  Rat   571 ARELLYSKAEEVLSLEKRKQQLCTAMEERVEEIKVHKAMLTSQIRYVDQQRQTVSSEFHERLSKI 635

  Fly   651 EAMKARFELTAQLLGKNEDGSIMTSTQLKVVSAQERQMLADEGDALNKKVLKAEKEVVALENTLR 715
            :.:|.|:|:...::...|.....|.:...:.:|||::.|..|||:|:.|:.|||||:.||:|||:
  Rat   636 DKLKNRYEILTVVMLPPEGEEEKTQSYYVIKAAQEKEELQREGDSLDAKISKAEKEIYALQNTLQ 700

  Fly   716 QFDKSNDNYRKTFRSVDENSKDRERAELELKELEAAYCRELEKLKVLRCKAQHYQQKHAAQRAEE 780
            .....|:||:::|:.|..:| |....:::|:|.:             |...:.|:.|....|..:
  Rat   701 VLSSCNNNYKQSFKKVTPSS-DEYGIKIQLEEQK-------------RSADEKYRCKQRQIRELQ 751

  Fly   781 EDLISK------IE----KAKASRAEHSAVLEKIERELDDQRMKLDRANREIRTQLREIK-ARPF 834
            ||:.|.      ||    .|:...:|...:..::.:|.::|:.|:.|..::.....|||: .|..
  Rat   752 EDIQSMENTFEVIEHLANNAREKLSEKQTLSFQLRKETEEQKPKIQRVTKQCGRLRREIRILRQT 816

  Fly   835 SEEYLAQFERDLSLQELEARNTKALNMITDLANSDESGTDIIGILLRKGIKLPMHLKRTCSRVSW 899
            ::|.|.  |:|:.|:|:...:.....|:.:...:.|..........:.|::||
  Rat   817 NDETLE--EQDIQLREIIQFHKDIDQMLVNAMENAEIHVIFQTYFQQNGLELP------------ 867

  Fly   900 NSSSSGKSSQGQDTASYLNVKGKKFSCDGASARSSVSDMSSLKDDTSSTTSHSGLSIISLELPLP 964
              ::.|.||:                   :|::||:|.:.||:|  |...|.....:|.|..|.|
  Rat   868 --TAKGPSSR-------------------SSSQSSLSSIRSLED--SIPISPPTAKVIELRFPGP 909

Fly 965 964
Rat 910 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17387	NP_649495.1	Smc	200..>853	CDD:224117	163/680 (24%)
Ccdc39	XP_017446344.1	Smc	22..695	CDD:224117	158/690 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352942
Domainoid	1	1.000	277	1.000	Domainoid score	I1669
eggNOG	1	0.900	-	-		E1_2C32D
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12149
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2872
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177902at33208
OrthoFinder	1	1.000	-	-		FOG0006077
OrthoInspector	1	1.000	-	-		oto96937
orthoMCL	1	0.900	-	-		OOG6_103837
Panther	1	1.100	-	-	LDO	PTHR18962
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800