DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14655 and CG11902

DIOPT Version :9

Sequence 1:	NP_649494.1	Gene:	CG14655 / 40594	FlyBaseID:	FBgn0037275	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_651389.3	Gene:	CG11902 / 43070	FlyBaseID:	FBgn0028647	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	456	Identity:	105/456 - (23%)
Similarity:	150/456 - (32%)	Gaps:	153/456 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TSVLCPLCAVPSFGSIDALQ-----QRLIKAANGPLACPFAN-CKELFLGLDKLTIHLFSHTSLM 62
            :|..|.:|.:......:..|     .|:.|.::|..:|.|.: |.|           :.||
  Fly  1111 SSYTCNMCQLRCLRKFELYQHQQAMHRMEKISDGCDSCLFKSVCPE-----------IISH---- 1160

  Fly    63 AQEGNESPANGQPASSRGFLAAAPPKRRAKRTRSKPVVPTPPPVRTTPPAHCDICEFSFRNTELR 127
                                    .||.....|.|..             .|..|.:.|......
  Fly  1161 ------------------------HKRTQCENREKQF-------------KCTRCGYKFMWESNL 1188

  Fly   128 DMHVRLVHENAEGE--PKQKEPQQKEPDQE--PYKCHLCSKTFRMKGSLRIHLKVVHMMGVPCSN 188
            .:|:.|.|...|.:  .:.||....||..|  .::|.||::.:..|..|..|||..|       .
  Fly  1189 LLHMDLQHVKTEDQELDESKEASGDEPKTEGQVFQCGLCTRKYNRKDRLTAHLKKFH-------G 1246

  Fly   189 PNPNPNPSPTPASTTSAVTATPKLSICDRIRHTEPGALGNGNNSTCTASQPYALSGALSMLQQSP 253
            |:..|:.:.||                                                   ..|
  Fly  1247 PDCKPSTAKTP---------------------------------------------------NRP 1260

  Fly   254 SSPESGTATPKLWECDVCSKSFTTKYFLKKHKRLHTGEMPYTCEICARTFTFQQSYHKHLLYHSE 318
            .||:.    ||.:.|..|.|:.::...|..|.|.||||.|:.||.|...|........|...|:.
  Fly  1261 ISPKE----PKRFLCAFCGKAVSSSSNLIIHMRRHTGEKPFKCEYCTMAFPRSSDLQCHRRTHTG 1321

  Fly   319 VKPHVCGVCGRAFKELSTLHNHQRIHSGEKPFKCEVCGKCFRQRVSFLVHTRIHTGVMPYKCELC 383
            .:||||.||.:.|.....|..|.||||||:|:||..|.|.|.|.....:|.|.|||..||:|.:|
  Fly  1322 ERPHVCTVCQKGFARSYKLQQHMRIHSGERPYKCTYCEKSFTQSNDLTLHIRRHTGERPYQCGVC 1386

  Fly   384 QKTFRYKVSQRTHRCPTEEAQTPEQLIKAFLEGNDSHTQPSPASAEIAAINSSSIVDPEQEALLS 448
            .:.|....:.:.||.....          :.||.:|                   |:|.:..:|.
  Fly  1387 GERFIQGTALKNHRMQQSH----------YEEGQES-------------------VEPTRRTVLE 1422

  Fly   449 Q 449
            |
  Fly  1423 Q 1423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14655	NP_649494.1	C2H2 Zn finger	268..288	CDD:275368	6/19 (32%)
		zf-H2C2_2	281..304	CDD:290200	11/22 (50%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		zf-H2C2_2	339..361	CDD:290200	13/21 (62%)
		C2H2 Zn finger	352..372	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..389	CDD:290200	10/24 (42%)
		C2H2 Zn finger	380..396	CDD:275368	3/15 (20%)
CG11902	NP_651389.3	zf-AD	6..83	CDD:285071
		C2H2 Zn finger	208..228	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	384..405	CDD:275368
		C2H2 Zn finger	417..437	CDD:275368
		C2H2 Zn finger	447..463	CDD:275368
		C2H2 Zn finger	578..599	CDD:275368
		C2H2 Zn finger	610..629	CDD:275368
		C2H2 Zn finger	640..660	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	706..726	CDD:275368
		C2H2 Zn finger	762..782	CDD:275368
		C2H2 Zn finger	866..887	CDD:275368
		C2H2 Zn finger	896..918	CDD:275368
		C2H2 Zn finger	926..947	CDD:275368
		C2H2 Zn finger	967..987	CDD:275368
		C2H2 Zn finger	996..1016	CDD:275368
		C2H2 Zn finger	1044..1063	CDD:275368
		C2H2 Zn finger	1224..1244	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1271..1291	CDD:275368	6/19 (32%)
		zf-H2C2_2	1283..1306	CDD:290200	11/22 (50%)
		COG5048	1295..>1367	CDD:227381	29/71 (41%)
		C2H2 Zn finger	1299..1319	CDD:275368	5/19 (26%)
		zf-H2C2_2	1311..1336	CDD:290200	9/24 (38%)
		C2H2 Zn finger	1327..1347	CDD:275368	7/19 (37%)
		zf-H2C2_2	1340..1364	CDD:290200	14/23 (61%)
		C2H2 Zn finger	1355..1375	CDD:275368	7/19 (37%)
		zf-H2C2_2	1367..1392	CDD:290200	10/24 (42%)
		C2H2 Zn finger	1383..1401	CDD:275368	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100