DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14655 and Kr

DIOPT Version :9

Sequence 1:	NP_649494.1	Gene:	CG14655 / 40594	FlyBaseID:	FBgn0037275	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001261181.1	Gene:	Kr / 38012	FlyBaseID:	FBgn0001325	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	131/556 - (23%)
Similarity:	204/556 - (36%)	Gaps:	164/556 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 STSVLCPLCAVPSFGSIDALQQRLIKAANGPLACPFANCKELFLGLDKLTIHLFSHTSLMAQEGN 67
            :||........|:.|    |||....:|.|                      :.|.|.|:|
  Fly    41 NTSATSAAAIYPAMG----LQQAAAASAFG----------------------MLSPTQLLA---- 75

  Fly    68 ESPANGQPASSRGFLAAAP---------PKRRAKRTRSKPVVPTPPPVRT---TPPA--HCDICE 118
               ||.|.|:   |:|..|         |...|....:.....:.||..|   :|||  |..:
  Fly    76 ---ANRQAAA---FMAQLPMSTLANTLFPHNPAALFGAWAAQQSLPPQGTHLHSPPASPHSPL-- 132

  Fly   119 FSFRNTELRDMHVRLVHENAEGEPKQKEPQQKEPDQEPYKCHLCSKTFRMKGSLRIHLKVVHMMG 183
                :|.|......|...|:       .||..||.::..|..: .|.|:.:.|:.:: .:.|..|
  Fly   133 ----STPLGSGKHPLNSPNS-------TPQHHEPAKKARKLSV-KKEFQTEISMSVN-DMYHTSG 184

  Fly   184 VPCSNPNPNPNPSPTPASTTSAVTATPKLSICDRIRHTEPGALGNGNNSTCTASQPYALSGALSM 248
            .|.|.|:...:|:.|                     |.     |.|.|:.|..
  Fly   185 GPISPPSSGSSPNST---------------------HD-----GAGGNAGCVG------------ 211

  Fly   249 LQQSPSSPESGTATPKLWECDVCSKSFTTKYFLKKHKRLHTGEMPYTCEICARTFTFQQSYHKHL 313
            :.:.||..:|.|       |.:||:||..|:.|:.|:|.||||.|:.|..|.:.||.......|:
  Fly   212 VSKDPSRDKSFT-------CKICSRSFGYKHVLQNHERTHTGEKPFECPECHKRFTRDHHLKTHM 269

  Fly   314 LYHSEVKPHVCGVCGRAFKELSTLHNHQRIHSGEKPFKCEVCGKCFRQRVSFLVHTRIHTGVMPY 378
            ..|:..||:.|..|.|.|.:::.|..|.|:|:||:|:.||:|...|........|..:|.|..|:
  Fly   270 RLHTGEKPYHCSHCDRQFVQVANLRRHLRVHTGERPYTCEICDGKFSDSNQLKSHMLVHNGEKPF 334

  Fly   379 KCELCQKTFRYKVSQRTHRCPTEEAQTPEQLIKAFLEGNDSHTQPSPASAEIAAINSSS------ 437
            :||.|...||.:.....|:|..:...||  .:...:.|:      .|.:....||.:|:
  Fly   335 ECERCHMKFRRRHHLMNHKCGIQSPPTP--ALSPAMSGD------YPVAISAIAIEASTNRFAAM 391

  Fly   438 ---------IVD-----PEQEALL------SQSIDDIVVEQCQKLGICGVEPREEGQ----LISL 478
                     .||     ||.:..|      :.|:|          |.|....|.:.|    :..|
  Fly   392 CATYGGSNESVDMEKATPEDDGPLDLSEDGASSVD----------GHCSNIARRKAQDIRRVFRL 446

  Fly   479 QPVAVVHFSGNGSPLQQLQNLRIYSP------QQTE 508
            .|..:.|...:.....:.::|.::||      :||:
  Fly   447 PPPQIPHVPSDMPEQTEPEDLSMHSPRSIGSHEQTD 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14655	NP_649494.1	C2H2 Zn finger	268..288	CDD:275368	9/19 (47%)
		zf-H2C2_2	281..304	CDD:290200	10/22 (45%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		zf-H2C2_2	339..361	CDD:290200	10/21 (48%)
		C2H2 Zn finger	352..372	CDD:275368	5/19 (26%)
		zf-H2C2_2	364..389	CDD:290200	8/24 (33%)
		C2H2 Zn finger	380..396	CDD:275368	5/15 (33%)
Kr	NP_001261181.1	C2H2 Zn finger	224..244	CDD:275368	9/19 (47%)
		zf-H2C2_2	237..261	CDD:290200	11/23 (48%)
		C2H2 Zn finger	252..272	CDD:275368	5/19 (26%)
		zf-H2C2_2	264..289	CDD:290200	8/24 (33%)
		C2H2 Zn finger	280..300	CDD:275368	7/19 (37%)
		zf-H2C2_2	292..316	CDD:290200	10/23 (43%)
		C2H2 Zn finger	308..328	CDD:275368	5/19 (26%)
		zf-H2C2_2	321..345	CDD:290200	8/23 (35%)
		C2H2 Zn finger	336..352	CDD:275368	5/15 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	54	1.000	Inparanoid score	I1809
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.150