DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14655 and ZNF358

DIOPT Version :9

Sequence 1:	NP_649494.1	Gene:	CG14655 / 40594	FlyBaseID:	FBgn0037275	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_060553.4	Gene:	ZNF358 / 140467	HGNCID:	16838	Length:	568	Species:	Homo sapiens

Alignment Length:	382	Identity:	103/382 - (26%)
Similarity:	148/382 - (38%)	Gaps:	99/382 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 TRSKPVVPTPPPVRTTP-----PAHCDICEFSFRNTELRDMHVRLVHENAEGEPKQKEP------ 147
            |.:..|:.|.|.|...|     |..|..|..:||.:.....| |..|   .||...:.|
Human   128 TATPQVLATSPAVLPAPASPPRPFSCPDCGRAFRRSSGLSQH-RRTH---SGEKPYRCPDCGKSF 188

  Fly   148 -------QQK--EPDQEPYKCHLCSKTFRMKGSLRIHLKVVHMMGVPCSNPNPNPNPSPTPASTT 203
                   |.:  .....||:|..|.|.|..:.:|..|..         |:....|:..|
Human   189 SHGATLAQHRGIHTGARPYQCAACGKAFGWRSTLLKHRS---------SHSGEKPHHCP------ 238

  Fly   204 SAVTATPKLSICDRIRHTEPGALGNGNNSTCTASQPYALSGALSMLQQSPSSPESGTATPKLWEC 268
                      :|.:       |.|:|                 |:|.|...: ..|   |:..:|
Human   239 ----------VCGK-------AFGHG-----------------SLLAQHLRT-HGG---PRPHKC 265

  Fly   269 DVCSKSFTTKYFLKKHKRLHTGEMPYTCEICARTFTFQQSYHKHLLYHSEVKPHVCGVCGRAFKE 333
            .||:|.|.....|.||.|.||||.||.|..|.:.|....:..:|...|:..:|:.|..||:||.:
Human   266 PVCAKGFGQGSALLKHLRTHTGERPYPCPQCGKAFGQSSALLQHQRTHTAERPYRCPHCGKAFGQ 330

  Fly   334 LSTLHNHQRIHSGEKPFKCEVCGKCFRQRVSFLVHTRIHTGVMPYKCELCQKTFRYKVSQRTHRC 398
            .|.|.:|.|||:||:|:.|..|.|.|.|..:.|.|..:|:|..||:|:||.|.|....|...|
Human   331 SSNLQHHLRIHTGERPYACPHCSKAFGQSSALLQHLHVHSGERPYRCQLCGKAFGQASSLTKH-- 393

  Fly   399 PTEEAQTPEQLIKAFLEGNDSHTQPSPASAEIAA--------INSSSIVDPEQEALL 447
                        |...||..:....:.|:|..||        ::.:|::.|.|.:||
Human   394 ------------KRVHEGAAAAAAAAAAAAAAAAAGLGLGPGLSPASMMRPGQVSLL 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14655	NP_649494.1	C2H2 Zn finger	268..288	CDD:275368	9/19 (47%)
		zf-H2C2_2	281..304	CDD:290200	12/22 (55%)
		C2H2 Zn finger	324..344	CDD:275368	9/19 (47%)
		zf-H2C2_2	339..361	CDD:290200	11/21 (52%)
		C2H2 Zn finger	352..372	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..389	CDD:290200	11/24 (46%)
		C2H2 Zn finger	380..396	CDD:275368	6/15 (40%)
ZNF358	NP_060553.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..117
		COG5048	<35..339	CDD:227381	67/267 (25%)
		lambda-1	108..>174	CDD:212564	14/49 (29%)
		zf-C2H2	151..173	CDD:278523	6/22 (27%)
		C2H2 Zn finger	153..173	CDD:275368	6/20 (30%)
		zf-H2C2_2	166..190	CDD:290200	6/27 (22%)
		C2H2 Zn finger	181..201	CDD:275368	2/19 (11%)
		zf-H2C2_2	194..216	CDD:290200	6/21 (29%)
		C2H2 Zn finger	209..229	CDD:275368	6/28 (21%)
		zf-H2C2_2	222..244	CDD:290200	6/53 (11%)
		C2H2 Zn finger	237..257	CDD:275368	8/60 (13%)
		zf-H2C2_2	250..272	CDD:290200	8/25 (32%)
		C2H2 Zn finger	265..285	CDD:275368	9/19 (47%)
		zf-H2C2_2	277..300	CDD:290200	12/22 (55%)
		zf-C2H2_8	292..370	CDD:292531	27/77 (35%)
		C2H2 Zn finger	293..313	CDD:275368	4/19 (21%)
		zf-H2C2_2	305..328	CDD:290200	6/22 (27%)
		C2H2 Zn finger	321..341	CDD:275368	9/19 (47%)
		zf-H2C2_2	333..356	CDD:290200	11/22 (50%)
		C2H2 Zn finger	349..369	CDD:275368	7/19 (37%)
		zf-H2C2_2	361..384	CDD:290200	10/22 (45%)
		zf-C2H2	375..397	CDD:278523	9/35 (26%)
		C2H2 Zn finger	377..397	CDD:275368	8/33 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..568
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910