DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14655 and znf865

DIOPT Version :9

Sequence 1:	NP_649494.1	Gene:	CG14655 / 40594	FlyBaseID:	FBgn0037275	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001120386.1	Gene:	znf865 / 100145461	XenbaseID:	XB-GENE-5959428	Length:	942	Species:	Xenopus tropicalis

Alignment Length:	521	Identity:	125/521 - (23%)
Similarity:	192/521 - (36%)	Gaps:	110/521 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 CPLCAVPSFGSIDALQQRLIKAANGPLACPFANCKELFLGLDKLTIHLFSHTSLMAQEGNES--P 70
            |.:|......|...:|..|:.....|..|  ..|...:..:..|..|...|......|...|  |
Frog   174 CTVCQKSFKQSSHLVQHMLVHTGERPYEC--NTCGRTYNHISSLIRHRRCHKEETEAEVTNSVPP 236

  Fly    71 ANGQPASSRGFLAAAPP--KRRAKRTRSKPV------VPTPP--PVRTT---------------- 109
            .:|:.|::...:|||..  ...|..:...||      :|.|.  |...|
Frog   237 PDGEAAAAAAVVAAAAAAMSEAAAGSAEMPVTGSEQSIPLPQDGPFTCTLCWKVFKKQSHLHQHQ 301

  Fly   110 ------PPAHCDICEFSFRNTELRDMHVRLVHENAEGE---------------PKQKEPQQKEPD 153
                  .|..|.:|..||...|....||:...::.:.:               ..|.....:.||
Frog   302 IIHTGEKPFSCSVCAKSFNRRESLKRHVKTHSDSMKVQCEVCGKSFRDTSYLLKHQATHTGERPD 366

  Fly   154 QEPYKCHLCSKTFRMKGSLRIHLKVVHMMGVPCSNPNPNPNP--SPTPASTTSAVTATPKLSICD 216
               |||.||.|::....||..| |.||..|:....|......  |......||:||......:..
Frog   367 ---YKCELCGKSYAAPQSLLRH-KQVHEQGLALQQPMVQQQQPLSEVIKEPTSSVTIEAASLLGT 427

  Fly   217 RIRHTEPGALGNGNNSTCTASQPYALSGALSMLQQSPSSPESGTATPKLWECDVCSKSFTTKYFL 281
            .:.:..|.|:..........||        |.||:.||...:..   |.:.|:||.:.|..:..|
Frog   428 DVSNVGPAAISVIGKIGSFFSQ--------SSLQKPPSVINNAN---KNFCCNVCGRGFGRRETL 481

  Fly   282 KKHKRLHTGEMPYTCEICARTFTFQQSYH--KHLLYHSEVKPHVCGVCGRAFKELSTLHNHQRIH 344
            |:|:|:||||.|:.|.:|.:  .|::|:|  ||.:.|:..:|:.|.:||:.|....:|..|::||
Frog   482 KRHERIHTGEKPHQCSVCGK--RFRESFHLTKHHVVHTRERPYKCELCGKVFGYPQSLTRHKQIH 544

  Fly   345 SGEKP--------------FKCEVCGKCFRQRVSFLVHTRIHTGVMPYKCELCQKTFRY------ 389
            ..:.|              |.|..||:.|......:.|..:|....||.|:.|.|.|.:
Frog   545 RLQLPCTVATGTLPPDRLTFGCTDCGERFPDSFHLMNHKELHMNEKPYVCDTCGKCFGFIENLMW 609

  Fly   390 ------KVSQRTHRCPTEEAQ--TPEQLIKAFLEGNDSHTQPSPAS-AEIAAINSSS--IVDPEQ 443
                  ..::|.|  |..:.|  ...|.:...     ..|.||..| ||:||..:::  :..|.:
Frog   610 HKLVHQTAAERLH--PISQCQDVAESQQVNCL-----ETTAPSDVSGAEVAAAAAAAGVVASPFE 667

  Fly   444 E 444
            |
Frog   668 E 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14655	NP_649494.1	C2H2 Zn finger	268..288	CDD:275368	8/19 (42%)
		zf-H2C2_2	281..304	CDD:290200	11/22 (50%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		zf-H2C2_2	339..361	CDD:290200	9/35 (26%)
		C2H2 Zn finger	352..372	CDD:275368	5/19 (26%)
		zf-H2C2_2	364..389	CDD:290200	8/24 (33%)
		C2H2 Zn finger	380..396	CDD:275368	5/27 (19%)
znf865	NP_001120386.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	66..106
		COG5048	156..616	CDD:227381	110/460 (24%)
		C2H2 Zn finger	174..194	CDD:275368	5/19 (26%)
		C2H2 Zn finger	202..220	CDD:275368	4/19 (21%)
		C2H2 Zn finger	284..304	CDD:275368	1/19 (5%)
		C2H2 Zn finger	312..332	CDD:275368	7/19 (37%)
		C2H2 Zn finger	340..360	CDD:275368	1/19 (5%)
		C2H2 Zn finger	369..389	CDD:275370	8/20 (40%)
		COG5048	448..928	CDD:227381	67/241 (28%)
		C2H2 Zn finger	468..488	CDD:275368	8/19 (42%)
		zf-H2C2_2	481..503	CDD:290200	11/23 (48%)
		C2H2 Zn finger	496..516	CDD:275368	7/21 (33%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		C2H2 Zn finger	566..586	CDD:275368	5/19 (26%)
		C2H2 Zn finger	594..614	CDD:275368	4/19 (21%)
		C2H2 Zn finger	680..700	CDD:275368
		C2H2 Zn finger	708..728	CDD:275368
		C2H2 Zn finger	736..756	CDD:275368
		zf-H2C2_2	749..773	CDD:290200
		C2H2 Zn finger	764..784	CDD:275368
		C2H2 Zn finger	792..812	CDD:275368
		C2H2 Zn finger	820..840	CDD:275368
		zf-H2C2_2	832..855	CDD:290200
		C2H2 Zn finger	848..868	CDD:275368
		C2H2 Zn finger	876..893	CDD:275368
		C2H2 Zn finger	904..924	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910