DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment atms and paf1

DIOPT Version :9

Sequence 1:	NP_001262263.1	Gene:	atms / 40593	FlyBaseID:	FBgn0010750	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_989348.1	Gene:	paf1 / 394974	XenbaseID:	XB-GENE-5797651	Length:	520	Species:	Xenopus tropicalis

Alignment Length:	543	Identity:	269/543 - (49%)
Similarity:	329/543 - (60%)	Gaps:	29/543 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPPTINNSAVNSAAEKRPQRQT-ERKSEIICRVKYGNNLPDIPFDLKFLQYPFDSHRFVQYNPTS 64
            |.|||...|......:....:| ..:|.::|||||.|.|||||||.||:.||||.:|||||..||
Frog     1 MAPTIQTQAQREDGHRSSSHRTVPERSGVVCRVKYCNTLPDIPFDPKFITYPFDQNRFVQYKATS 65

  Fly    65 LERNFKYDVLTEHDLGVTVDLINRELYQADSMTLLDPADEKLLEEETLTPTDSVRSRQHSRTVSW 129
            ||:..|:|:|||.|||||:||||.:.|:.|....||.|||||||||...|:.|.||:||::.|.|
Frog    66 LEKQHKHDLLTEPDLGVTIDLINPDTYRIDPNVTLDIADEKLLEEEIQAPSSSKRSQQHAKVVPW 130

  Fly   130 LRKSEYISTEQTRFQPQNLENIEAKVGYNVKKSLREETLYLDREAQIKAIEKTFSDTKSEITKHY 194
            :||:||||||..|:...| |..|.|:|.:||:...||.:|.||::||.||||||.|.:..|::||
Frog   131 MRKTEYISTEFNRYGVSN-EKPEVKIGVSVKQQFTEEDIYKDRDSQISAIEKTFEDAQKPISQHY 194

  Fly   195 SKPNVVPVEVLPIFPDFTNWKFPCAQVIFDSDPAPAGKNVPAQLEEMSQAMIRGVMDESGEQFVA 259
            |||.|.||||:|:||||..|..|||||||||||||...:..|.|:.||||||||:|||.|.||||
Frog   195 SKPRVTPVEVMPVFPDFKMWINPCAQVIFDSDPAPKDASGSAALDMMSQAMIRGMMDEEGNQFVA 259

  Fly   260 YFLPTEQTLEKRRTDFINGELYKEEEEYEYKIAREYNWNVKTKASKGYEENYFFVMRQ-DGIYYN 323
            ||||.|:|:.||:.|...|..|..|:.|:||||||||||||.||||||||||||:.|: ||:|||
Frog   260 YFLPGEETMRKRKRDQEEGLDYMPEDIYDYKIAREYNWNVKNKASKGYEENYFFIFREGDGVYYN 324

  Fly   324 ELETRVRLNKRRVKVG-QQPNNTKLVVKHRPLDSMEHRMQRYRERQLE--VPGEEEEIVEEVREE 385
            ||||||||:|||||.| |...|..||||||.:...|...|..|..|||  .|.|||||  ||.:|
Frog   325 ELETRVRLSKRRVKAGVQSGTNAVLVVKHRDMHEKELEAQEARRAQLENHEPEEEEEI--EVDQE 387

  Fly   386 EQMQIIGETEKTSEDAAVGAQA-ASGADSPAQVARDRQSRSRSRTRSGSSSGSGSGSGSRASSRS 449
            .|.....:.||.|.....|:.| .||::|..:.|.:.:........|         |....::|.
Frog   388 TQGSDAEDGEKGSGSEKEGSGAEQSGSESEREEAEEEEKEDEEEKES---------SEEDRAARD 443

  Fly   450 KSGSRSGSGSRSRTNSPAGSQKSGSRSRSVSRSRSRSKSGSRSRSRSRSKSGSRSRSGSRSGSGS 514
            |..........|..:.|..|.:.|..|.  |........|.||||.|.|..||         ..|
Frog   444 KEEIFGSDDDDSDEDGPNESGQDGEDSG--SDDEEEKGQGRRSRSASSSPFGS---------DHS 497

  Fly   515 RSPSRSRSGSPSGSGSSSGSASD 537
            :..:..:|.|..|||||:||.||
Frog   498 QQENEDQSASDQGSGSSTGSDSD 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
atms	NP_001262263.1	Paf1	27..414	CDD:281915	229/391 (59%)
paf1	NP_989348.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		5/21 (24%)
		Paf1	30..409	CDD:367756	226/381 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	359..520		54/182 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	435	1.000	Domainoid score	I567
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5441
Inparanoid	1	1.050	463	1.000	Inparanoid score	I1516
OMA	1	1.010	-	-		QHG55946
OrthoDB	1	1.010	-	-		D418810at33208
OrthoFinder	1	1.000	-	-		FOG0004172
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23188
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R886
SonicParanoid	1	1.000	-	-		X5214
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110