DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG44098 and SLC22A13

DIOPT Version :9

Sequence 1:NP_001262264.1 Gene:CG44098 / 40590 FlyBaseID:FBgn0264907 Length:813 Species:Drosophila melanogaster
Sequence 2:NP_004247.2 Gene:SLC22A13 / 9390 HGNCID:8494 Length:551 Species:Homo sapiens


Alignment Length:606 Identity:139/606 - (22%)
Similarity:237/606 - (39%) Gaps:135/606 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   206 VDAVGQITGPWGKWQLRTVLLIFLCK---IPSSWFMACIIFTAPAPRHGEFFCKPPHTIGAQNQT 267
            |..:.:| |.:|::|::  |||.||.   :...:|.|.:......|.|........||.......
Human     5 VQVLAEI-GDFGRFQIQ--LLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNLSAAE 66

  Fly   268 QWI------KVSHPQKEESDDQEFSIDFCNVYQ------DAQEHAHHYYNYENSDQEP--RVWEK 318
            |.:      ...||:.            |.:::      ..|:...|.:|    :.:|  ..||.
Human    67 QLVLSVPLDTAGHPEP------------CLMFRPPPANASLQDILSHRFN----ETQPCDMGWEY 115

  Fly   319 PLHRNSNVIPCTEFQHESDYHSVVTQYDLVCSRDILVSVTQFFHLFGVLTGGILANQLLKYFSPR 383
            |    .|.:|           |:..:::|||.|..|...||...:.|:|.|.::...|......:
Human   116 P----ENRLP-----------SLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRK 165

  Fly   384 NVMLFGMITQIFCGNLTGHVASYELHVFFRCLSAVCCAQMYTAGGQIMADITGGKYRTCVSTLFE 448
            ..:|..::.....|..|..|.|:||::..|...|...|.:..:...::.:..|..:||....|.:
Human   166 ATILAQLLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQ 230

  Fly   449 QFWSIGVMMLPGVASFWSSWSHLYMAISWPTVILIYLWQWIPDSPRWLIARGRTQDAKKILLECV 513
            ..:|:|.|:|.|:|..:.:|..|.:..:.|.::|.:.:..:|:|.|||:.|||..:|.:::.:..
Human   231 CNFSLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAA 295

  Fly   514 EVNGTGYNLPHDIDQQL--ELQAQTAMDAPPPSGWWSMWKGERAVRH---------IVCVHLAWS 567
            .||          .::|  ||..|...:...|||     ......||         |.||   |.
Human   296 SVN----------RRKLSPELMNQLVPEKTGPSG-----NALDLFRHPQLRKVTLIIFCV---WF 342

  Fly   568 LYIVVYYGMLLNIRSFSRDHLYINTFFAGFSEMMGTFFGLFLILKTTRKWLWTGLFNIVAGCIAY 632
            :..:.|||:.|.:..|..| :|:.....|..|:......:|::.:..|||...|.. ::.|.:..
Human   343 VDSLGYYGLSLQVGDFGLD-VYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTL-VLGGLMCI 405

  Fly   633 CGWLVPKPSVIGLDPNVALLMCSAMVSKMAISTTLSILTTCTVELVSDDKKKITSFSTI------ 691
            ....:|      .|..|.:.|. |:|.|||.:...:|....:.||          |.||      
Human   406 IIIFIP------ADLPVVVTML-AVVGKMATAAAFTISYVYSAEL----------FPTILRQTGM 453

  Fly   692 ----CWARFWLLGAPFIGSTVVFGQ---LIPQTAFASLAILGG-LCTSLISSPRT---------- 738
                .::|...:..|.:   ::.|:   .:|...:.||.|:.| |||.|   |.|          
Human   454 GLVGIFSRIGGILTPLV---ILLGEYHAALPMLIYGSLPIVAGLLCTLL---PETHGQGLKDTLQ 512

  Fly   739 ------HPISRPSSPAAQGTQ 753
                  ||.|..|.|:.:.|:
Human   513 DLELGPHPRSPKSVPSEKETE 533

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG44098NP_001262264.1 2A0119 214..730 CDD:273328 126/557 (23%)
MFS 353..733 CDD:119392 96/404 (24%)
SLC22A13NP_004247.2 2A0119 12..510 CDD:273328 131/573 (23%)
MFS 139..500 CDD:119392 96/403 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 511..551 6/23 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165153435
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D704438at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.850

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