DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG44098 and SLC22A14

DIOPT Version :9

Sequence 1:	NP_001262264.1	Gene:	CG44098 / 40590	FlyBaseID:	FBgn0264907	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	XP_006713479.2	Gene:	SLC22A14 / 9389	HGNCID:	8495	Length:	675	Species:	Homo sapiens

Alignment Length:	674	Identity:	136/674 - (20%)
Similarity:	258/674 - (38%)	Gaps:	117/674 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 GTSAGDLEPKHLPLAP-NSPSNEQAKCEGPEGEANNNNSTSSNHNHNPNHIRTHRRQHEYQLYPN 185
            |..||.:....:.:.| |..:...|:..|.|.......|..::.|.|.:.:..|  .|.:.|  .
Human    56 GGRAGRVWRVEIMMTPGNFAAAFSAQMAGEENFKEELRSQDASRNLNQHEVAGH--PHSWSL--E 116

  Fly   186 DTFAQLEGKAPKPNTKMQTKVDAVGQITGPWGKWQLRTVLLIFLCKIPSSWFMAC--IIFTAPAP 248
            ....:|.....|.:.|....:||||:    :|.:|.|.|.|.|:..|.|::||..  .:|||..|
Human   117 MLLRRLRAVHTKQDDKFANLLDAVGE----FGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKP 177

  Fly   249 RHGEFFCKPPHTIGAQNQTQWIKVSHPQKEESDDQEFSID--------FCNVYQDAQEHAHH--Y 303
                 :|          .|.||....|...:::....:|.        .|.:|.....:...  .
Human   178 -----YC----------NTSWILAVGPHLSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQ 227

  Fly   304 YNYENSDQEPRVWEKPLHRNSNVIPCTEFQHESDYHSVVTQYDLVCSRDILVSVTQFFHLFGVLT 368
            :...::|.....|..|               ::...|::.::||||..:......|...:.|:..
Human   228 FGLNDTDTCQDGWIYP---------------DAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPI 277

  Fly   369 GGILANQLLKYFSPRNVMLFGMITQIFCGNLTGHVASYELHVFFR----------CLSAVCCAQM 423
            |.::...:.........:|..::..|..|..|..:.|:.|::|||          .:|::..|..
Human   278 GSLIFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATE 342

  Fly   424 YTAGGQIMADITGGKYRTCVSTLFEQFWSIGVMMLPGVASFWSSWSHLYMAISWPTVI--LIYLW 486
            :..          |::|.....|...|:::|.::|.|:|.....|..|:: :....||  :.|:|
Human   343 WLV----------GEHRAHAIILGHCFFAVGAVLLTGIAYSLPHWQLLFL-VGGILVIPFISYIW 396

  Fly   487 QWIPDSPRWLIARGRTQDAKKILLECVEVNGTGYNLPHDIDQQLELQAQTAMDAPPPSGWWSMWK 551
             .:|:|||||:.:|:.::||::|.....||..  .:|.::..:|:|..:....|    ......|
Human   397 -ILPESPRWLMMKGKVKEAKQVLCYAASVNKK--TIPSNLLDELQLPRKKVTRA----SVLDFCK 454

  Fly   552 GERAVRHIVCVHLAWSLYIVVYYGMLLNIRSFSRDHLYINTFF----AGFSEMMGTFFGLFLILK 612
            ..:..:..:.:...|......|:.:.|.:|     .|.::..|    ....|:......:||:.:
Human   455 NRQLCKVTLVMSCVWFTVSYTYFTLSLRMR-----ELGVSVHFRHVVPSIMEVPARLCCIFLLQQ 514

  Fly   613 TTRKW-LWTGLFNIVAGCIAY-----------CGWLVPKPSVIGLDPNVALLMCSAMVSKMAIST 665
            ..||| |...|...:..|:..           ..|  |:.....|.....|::   |:.:.:::.
Human   515 IGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKW--PRCPATELKSMTILVL---MLREFSLAA 574

  Fly   666 TLSILTTCTVELVSDDKKK----ITSFSTICWARFWLLGAPFIGSTVVFGQLIPQTAFASLAILG 726
            |:::....|.||:....:.    :.|.:::..|   :|....|..|   ..|:|......|||:.
Human   575 TVTVFFLYTAELLPTVLRATGLGLVSLASVAGA---ILSLTIISQT---PSLLPIFLCCVLAIVA 633

  Fly   727 GLCTSLISSPRTHPISRPSSPAAQ 750
            ...:||:...|..|:|...:.::|
Human   634 FSLSSLLPETRDQPLSESLNHSSQ 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG44098	NP_001262264.1	2A0119	214..730	CDD:273328	109/559 (19%)
CG44098	NP_001262264.1	MFS	353..733	CDD:119392	80/411 (19%)
SLC22A14	XP_006713479.2	2A0119	141..650	CDD:273328	114/576 (20%)
SLC22A14	XP_006713479.2	MFS	270..641	CDD:119392	80/404 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153531
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704438at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850