DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG44098 and SLC22A6

DIOPT Version :9

Sequence 1:NP_001262264.1 Gene:CG44098 / 40590 FlyBaseID:FBgn0264907 Length:813 Species:Drosophila melanogaster
Sequence 2:NP_004781.2 Gene:SLC22A6 / 9356 HGNCID:10970 Length:563 Species:Homo sapiens


Alignment Length:596 Identity:125/596 - (20%)
Similarity:225/596 - (37%) Gaps:99/596 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   207 DAVGQITGPWGKWQLRTVLLIFLCKIPSSWFMACIIFTAPAPRHGEFFCKPPHTIGAQNQTQWIK 271
            |.:.|:.|. |::|...|.|:.|..:..:.......|||..|.|   .|:||..... ::...::
Human     5 DLLQQVGGV-GRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTH---HCRPPADANL-SKNGGLE 64

  Fly   272 VSHPQKEESDDQEFSIDFCNVYQDAQEHAHHYYNYENSDQEPRVWEKPLHRNSN------VIPCT 330
            |..|:     |::...:.|..:...|                  |..|....:.      ..|||
Human    65 VWLPR-----DRQGQPESCLRFTSPQ------------------WGLPFLNGTEANGTGATEPCT 106

  Fly   331 E---FQHESDYHSVVTQYDLVCSRDILVSVTQFFHLFGVLTGGILANQLLKYFSPRNVMLFGMIT 392
            :   :.:.:...::||::|||||...|..:.|..::.|||.|.::...|......|.|::...:.
Human   107 DGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQ 171

  Fly   393 QIFCGNLTGHVASYELHVFFRCLSAVCCA----QMYTAGGQIMADITGGKYRTCVSTLFEQFWSI 453
            ....|.......::.::..||.||.:..|    ...|...:.|...|    |.||.||....:|:
Human   172 TAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHT----RACVGTLIGYVYSL 232

  Fly   454 GVMMLPGVASFWSSWSHLYMAISWP-TVILIYLWQWIPDSPRWLIARGRTQDAKKILLECVEVNG 517
            |..:|.|||.....|.||.:.:|.| ....||.|.:| :|.||..:.||.....:.|.....:||
Human   233 GQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFI-ESARWHSSSGRLDLTLRALQRVARING 296

  Fly   518 ---TGYNLPHDIDQQLELQAQTAMDAPPPSGWWSMWKGERA---------VRHI-VCVHLAWSLY 569
               .|..|..::     |:|....:.       :|.||:.:         :||: :|:.:.|...
Human   297 KREEGAKLSMEV-----LRASLQKEL-------TMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349

  Fly   570 IVVYYGMLLNIRSFSRDHLYINTFFAGFSEMMGTFFGLFLILKTTRKWLWTGLFNIVAGCIAYCG 634
            ...|||::::::.|......|...| |..::.....|..:|....|:........:...||...|
Human   350 SFAYYGLVMDLQGFGVSIYLIQVIF-GAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNG 413

  Fly   635 WLVPKPSVIGLDPNVALLMCSAMVSKMAISTTLSILTTCTVELVSDDKKKITSFSTICWARFWLL 699
            .:....|::    ..:|    |::.|..::.:.:.:...|.||.....::.........||...:
Human   414 VIPQDQSIV----RTSL----AVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSI 470

  Fly   700 GAPFIGSTVVFGQLIPQTAFASLAILGGLCTSLISSPRTHPISRPSSPAAQGTQNITSQFTIIDG 764
            .:|.:..|......:|...:.::.:.....|.|:  |.|     ...|.....|::.|:      
Human   471 VSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLL--PET-----LGQPLPDTVQDLESR------ 522

  Fly   765 MDNKGYSPTSK 775
                 ::||.|
Human   523 -----WAPTQK 528

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG44098NP_001262264.1 2A0119 214..730 CDD:273328 113/542 (21%)
MFS 353..733 CDD:119392 83/397 (21%)
SLC22A6NP_004781.2 2A0119 11..515 CDD:273328 118/564 (21%)
MFS 135..505 CDD:119392 83/397 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..563 3/4 (75%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165153513
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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