DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG44098 and Slc22a23

DIOPT Version :9

Sequence 1:	NP_001262264.1	Gene:	CG44098 / 40590	FlyBaseID:	FBgn0264907	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_001028339.1	Gene:	Slc22a23 / 73102	MGIID:	1920352	Length:	689	Species:	Mus musculus

Alignment Length:	536	Identity:	109/536 - (20%)
Similarity:	202/536 - (37%)	Gaps:	109/536 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 NYENSDQEPRVWEKPLHRNSNVIPCTEFQHESDY-------HSVVTQYDLVCSRDILVSVTQFFH 362
            |..||...|.: ..|..:.:|...|.  .|..||       .:||:::||||.....|.:.:|..
Mouse   170 NRSNSSDTPPL-PSPPGKGNNDSNCD--CHAWDYGIRTGLIQNVVSKWDLVCDNTWKVHIAKFSL 231

  Fly   363 LFGVLTGGILANQLLKYFSPRNVMLFGMITQIFCG---NLTGHVASYELHVFFR--CLSAVCCAQ 422
            |.|::.|.::...:..:...|.|:||..|..:..|   .|:.:|..:....||.  ||:.:...
Mouse   232 LVGLIFGYLITGCIADWVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILT- 295

  Fly   423 MYTAGGQIMADITGGKYRTCVSTLFEQFWSI-GVMMLPGVASFWSSWSHLYMAISWPTVILIYLW 486
            :|..  :|.....|.::   :.|:...|.:: |..::||:|:....|..|...|..|.::::..|
Mouse   296 LYAL--RIELCPPGKRF---IITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYW 355

  Fly   487 QWIPDSPRWLIARGRTQDAKKILL-----ECVEVNGTGYNLPHDIDQQLELQAQTAMDAPPPSGW 546
            ...|:|.|||:|..:.:.|||::|     .||........:..:::::|..:.:... .....|.
Mouse   356 SIFPESLRWLMATQQFESAKKLILYLTQKNCVSPESDIKGVMPELEKELSRRPKKVC-IVKVVGT 419

  Fly   547 WSMWKGERAVRHIVCVHLAWSLYIVVYYGMLLNIRSFSRDHL-------YINTFFAGFSEMMG-- 602
            .::||.    ..::||:      .:..||:   ...|:|..:       .:..|:|.:..|..
Mouse   420 RNLWKN----IVVLCVN------SLTGYGI---HHCFARSMMGHEVKVPLLENFYADYYTMASIA 471

  Fly   603 -----------TFFG------LFLILKTTRKWLWTGLFNIVAGCIAYCGWLVPKPSVIGLDPNV- 649
                       .|.|      ||:||......|..||.|::.....:....:.....:|:..:|
Mouse   472 LASCLAMCLVVKFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSELQLKLAVGMSDSVK 536

  Fly   650 ---------ALLMCSAMVSKMAI----STTLSILTTCTVELVSDDKKKITSFSTICWARFWLLGA 701
                     ..:..|..|..:::    ..|.:::....:.||            :..|.|.:|.|
Mouse   537 DKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLV------------LASAGFGMLTA 589

  Fly   702 PFIGSTVVFGQLIPQTAFASLAILGGLCTSLISSPRT-----------HPISRPSSPAAQGTQNI 755
            |.|......|..:....||...::..:|..|:...|.           |...:|..|..:|.|.:
Mouse   590 PIIELHNQKGYFLHHIIFACCTLICIICILLLPESRNQNLPENIANGEHYTRQPLLPHKKGEQPL 654

  Fly   756 TSQFTIIDGMDNKGYS 771
                 ::...:.|.||
Mouse   655 -----LLTNAELKDYS 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG44098	NP_001262264.1	2A0119	214..730	CDD:273328	98/482 (20%)
CG44098	NP_001262264.1	MFS	353..733	CDD:119392	83/430 (19%)
Slc22a23	NP_001028339.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		2A0119	98..631	CDD:273328	101/495 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..188		5/18 (28%)
		MFS	230..>359	CDD:119392	29/134 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843340
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930