Protein Alignment CG44098 and SLC22A5

DIOPT Version :9

• Sequence 1: NP_001262264.1
• Gene: CG44098 / 40590
• FlyBaseID: FBgn0264907
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_001295051.1
• Gene: SLC22A5 / 6584
• HGNCID: 10969
• Length: 581
• Species: Homo sapiens
• Alignment Length: 647
• Identity: 150/647 - (23%)
• Similarity: 241/647 - (37%)
• Gaps: 142/647 - (21%)

  Fly   207 DAVGQITGPWGKWQLRTVLLIFLCKIPSSWFMACIIFTAPAPRHGEFFCKPPHTIGAQNQTQWIK 271
            |.|....|.||.:|.....|:....||:.:.....:|....|.|.   |:.|.  .|...:.|..
Human     5 DEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHR---CRVPD--AANLSSAWRN 64

  Fly   272 VSHPQKEESDDQEFSIDFCNVYQDAQE--HAHHYY------NYENSDQEP-RVWEKPLHRNSNVI 327
            .:.|.:               .:|.:|  |:...|      |:.....|| |..:.......:.:
Human    65 HTVPLR---------------LRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCL 114

  Fly   328 PCTEFQHESDYHSVVT------------------------QYDLVCSRDILVSVTQFFHLFGVLT 368
            ...||..:....::||                        |::|||..|....:|......|||.
Human   115 DGWEFSQDVYLSTIVTEQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLL 179

  Fly   369 GGILANQLLKYFSPRNVML--FGMIT-----QIFCGNLTGHVASYELHVFFRCLSAVCCAQMYTA 426
            |..::.||...|..:||:.  .||.|     |||..|       :|:.|....|..:.....|.|
Human   180 GSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKN-------FEMFVVLFVLVGMGQISNYVA 237

  Fly   427 GGQIMADITGGKYRTCVSTL-FEQFWSIGVMMLPGVASFWSSWSHLYMAISWPTVILIYLWQWIP 490
            ...:..:|.|...|...||| ...|::.|.|:||..|.|...|..|.:|::.|.|:.:.||.:||
Human   238 AFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIP 302

  Fly   491 DSPRWLIARGRTQDAKKILLECVEVNGTGYNLPHDIDQQLEL--------QAQTAMDAPPPSGWW 547
            :||||||::||.::|:.|:.:..:.|  |..:|..|....||        |:...:|.      .
Human   303 ESPRWLISQGRFEEAEVIIRKAAKAN--GIVVPSTIFDPSELQDLSSKKQQSHNILDL------L 359

  Fly   548 SMWKGERAVRHIVCVH-LAWSLYIVVYYGMLLNIRSFSRDHLYINTFFAGFSEMMGTFFGLFLIL 611
            ..|.    :|.:..:. :.|....|.|:|:.|:..:...| :::|.|.:...|:........|:.
Human   360 RTWN----IRMVTIMSIMLWMTISVGYFGLSLDTPNLHGD-IFVNCFLSAMVEVPAYVLAWLLLQ 419

  Fly   612 KTTRKW-LWTGLFNIVAGCIAYCGWLVPKPSVIGLDPNV-ALLMCSAMVSKMAISTTLSILTTCT 674
            ...|:: :.|.||  :.|.:.....|||        |:: .|.....||.|..::...|::...|
Human   420 YLPRRYSMATALF--LGGSVLLFMQLVP--------PDLYYLATVLVMVGKFGVTAAFSMVYVYT 474

  Fly   675 VEL-----------VSDDKKKITSFSTICWARFWLLGAPFIGSTVVFGQLIPQTAFASLAILGGL 728
            .||           ||....::.|   |....|..|||        :.:.:|.....||.||..:
Human   475 AELYPTVVRNMGVGVSSTASRLGS---ILSPYFVYLGA--------YDRFLPYILMGSLTILTAI 528

  Fly   729 CTSLISSPRTHPISRPSSPAAQGT--QNITSQFTIIDGMDNK---GYSPTSKTIHSNSTILK 785
            .|..:             |.:.||  .:...|...:.||.::   .::...|......||||
Human   529 LTLFL-------------PESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILK 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG44098	NP_001262264.1	2A0119	214..730	CDD:273328	136/578 (24%)
		MFS	353..733	CDD:119392	105/409 (26%)
SLC22A5	NP_001295051.1	2A0119	12..544	CDD:273328	140/605 (23%)
		MFS	162..534	CDD:119392	106/425 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153472
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840