DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG44098 and slc22a23

DIOPT Version :9

Sequence 1:	NP_001262264.1	Gene:	CG44098 / 40590	FlyBaseID:	FBgn0264907	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_001338637.1	Gene:	slc22a23 / 555979	ZFINID:	ZDB-GENE-030131-3564	Length:	942	Species:	Danio rerio

Alignment Length:	707	Identity:	134/707 - (18%)
Similarity:	248/707 - (35%)	Gaps:	193/707 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 PNDTFAQLEGKAPKPNTKMQTKVDAVGQITGPWGKWQLRTVLLIFLCKIPS-----SWFMACIIF 243
            |.:.|...| .:..|....||....:..: |.:||:|.:   ||.|..||:     |.|....:.
Zfish    18 PENGFVTPE-TSKSPGLLSQTDGGVLPSV-GGFGKYQKQ---LIVLTWIPAIFIGFSQFSDNFLL 77

  Fly   244 TAPAPRHGEFFCKPPHTIGAQNQTQWIKVSHPQKEESDDQEFSIDFCNVYQDAQEHAH---HYYN 305
            |.|        |..||    .|.:|.:.|:        ....|..|..|..:|....:   ..|.
Zfish    78 TNP--------CPEPH----NNSSQLLTVA--------PTAVSTVFTGVNTEAASQCNCTPSSYK 122

  Fly   306 YENSDQEPRVWEKPLHRNSNVIPCTEFQHESDYHSVVTQYDLVCSRDILVSVTQFFHLFGVLTGG 370
            .:|.          |.:|                 :||:::|||.....:.:.:|..|.|.:.|.
Zfish   123 LQNG----------LEQN-----------------IVTKWNLVCDSAWKIHIAKFSLLVGSIFGY 160

  Fly   371 ILANQLLKYFSPRNVMLFGMITQIFCGNLTGHVASYELHVFFRCLSAVCCA----QMYTAGGQIM 431
            ::...|..:|....|::..::..:..|.......:..:....|.....|.|    .:|..  :|.
Zfish   161 LVLGVLADWFGRHPVLILSVVFLLVFGMTVAFSVNLPMFGTLRFFEGFCLAGITLSLYVL--RIE 223

  Fly   432 ADITGGKYRTCVSTLFEQFWSI-GVMMLPGVASFWSSWSHLYMAISWPTVILI-YLWQWIPDSPR 494
            ..:.|.::..   |:...|..: |.:::||:|:....|..|...|..|.:::: |:|.: |:|.|
Zfish   224 LCLPGWRFSI---TMVANFMMLAGQLLMPGLAALCRDWQILQAVIVCPLLLMLSYIWAF-PESLR 284

  Fly   495 WLIARGRTQDAKKILLECVEVNGTGYNLPHDIDQQLELQAQTAMDAPPPS-------GWWSMWKG 552
            ||:|..:...:|.|:....:.|  ..||..|. ::|..:...|:...|..       |..::||.
Zfish   285 WLLATQQYSRSKWIMERISKKN--NINLQEDA-EELMTELNGALQKQPKKTCIVKMVGTRNLWKN 346

  Fly   553 ERAVRHIVCVHLAWSLYIVVYYGMLLNIRSFSRDHLYINTFFAGFSEMMGTFFGLFLILKTTRKW 617
                ..::||:      .:..||:   ...|:|..:...|  .||.|.:..|:..:.::.
Zfish   347 ----IVVLCVN------SLTGYGI---HHCFARSMMEKKT--VGFVEKLHDFYAEYYVMA----- 391

  Fly   618 LWTGLFNIVAGCIAYCGWLVPKPSVIGLDPNVALLMCSAMVSKMAISTTLSILTTC-----TVEL 677
                   ::|  :|.|.:|.|..:::|....:.:.|   :::.:|....|.:|...     .:.|
Zfish   392 -------VIA--VASCVFLCPAVALMGRRGGLLMFM---IITALASLLQLGLLNLLGKYGDHLSL 444

  Fly   678 VSDDK---KKITSFSTI---------------------------------CWARFWLLGAPFIGS 706
            |..|:   |...:||.|                                 ..|.|.:|.:|.:..
Zfish   445 VHSDELNDKFSVAFSIIGMFSSHAVSNLSIFFCAEITPSVIRGGGLGLVLASAGFGMLTSPIMEL 509

  Fly   707 TVVFGQLIPQTAFASLAILGGLCTSLISSPRTHPISR---------------PSSPAAQG---TQ 753
            ....|..:....||...::..:|..|:...|..|:..               |..|..|.   |:
Zfish   510 HNQKGYFLHHIIFACCTLICIICILLLPETRNQPLPETLSDGESYTRQPLLPPRKPGEQRLLLTK 574

  Fly   754 NITSQF-------------TIIDGMDNKGYSPTSKTIHSNSTILKLNTPQSNLPPQL 797
            :.:.::             |::..||:...|...  ||     :.::.|....|.|:
Zfish   575 SESREYARVGDTPLHEAAATVVSTMDSTASSAVD--IH-----MLIDAPIQQEPAQV 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG44098	NP_001262264.1	2A0119	214..730	CDD:273328	111/577 (19%)
CG44098	NP_001262264.1	MFS	353..733	CDD:119392	80/433 (18%)
slc22a23	NP_001338637.1	Sugar_tr	<131..547	CDD:331684	88/456 (19%)
slc22a23	NP_001338637.1	Atrophin-1	630..>937	CDD:331285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588486
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930