DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG44098 and Slc22a14

DIOPT Version :9

Sequence 1:	NP_001262264.1	Gene:	CG44098 / 40590	FlyBaseID:	FBgn0264907	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_001032838.1	Gene:	Slc22a14 / 382113	MGIID:	2685974	Length:	629	Species:	Mus musculus

Alignment Length:	707	Identity:	157/707 - (22%)
Similarity:	284/707 - (40%)	Gaps:	150/707 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 EANNNNSTSSNHNHNPNHIRTHRRQHEYQLYPNDTFA------QLEGKAPKPNTKMQTKVDAVGQ 211
            |..|..:...:.|....|      :||.. :|:..::      :|:....:.:.|..:.:||:|:
Mouse     3 EDQNYKTAFGSQNSRDTH------RHEIS-FPSQNWSLEMLLRRLKAIDARRDDKFASVMDAIGE 60

  Fly   212 ITGPWGKWQLRTVLLIFLCKIPSSWFMAC--IIFTAPAPRHGEFFCKPPHTIGAQNQTQWIKVSH 274
                :|.:|.|.|:|.|:..|.|::|:..  .:.||..|     :|          .|.||....
Mouse    61 ----FGTFQWRLVVLTFIPSILSTFFIFSHHFLLTAQRP-----YC----------NTSWILEVG 106

  Fly   275 PQKEESDDQEFSIDF----------CNVY----QDAQEHAHHYYNYENSDQEPRVWEKPLHRNSN 325
            |...|  |::.::..          |.:|    .|.....|...||..:.:..  |..|
Mouse   107 PNLTE--DEQLNLTLPRAPNGSFLTCLMYIPVPWDLDSIIHFGLNYTETCKFG--WIYP------ 161

  Fly   326 VIPCTEFQHESDYHSVVTQYDLVCSRDILVSVTQFFHLFGVLTG----GILANQLLKYFSPRNVM 386
                  |.|.   .|::.::||||..:..........|.|||||    |.|:::|.:|    .::
Mouse   162 ------FAHT---RSLINEFDLVCGNEPNKENGLTVFLSGVLTGSLLFGFLSDKLGRY----PII 213

  Fly   387 LFGMITQIFCGNLTGHVASYELHVFFRCLSAVCCAQMYTAGGQIMADITGGKYRTCVSTLFEQFW 451
            |..::..:..|..|..|:|:..::|||...|............::.:...|::|.....|...|.
Mouse   214 LLSLLGFLIFGFGTAFVSSFYQYLFFRFFVAQASVGYAICSVSLVMEWLVGEHRAQAVILQHSFL 278

  Fly   452 SIGVMMLPGVASFWSSWSHLYMAISWPTVILI-YLWQWIPDSPRWLIARGRTQDAKKILLECVEV 515
            :|||::|.|:|.....|..|.:....|...|| .:|. :.:|||||:.||:.::|||:|....||
Mouse   279 TIGVILLTGLAYKVVHWRLLCLLGGMPMFPLICNIWV-LRESPRWLMVRGKVEEAKKVLCYAAEV 342

  Fly   516 NGTGYNLPHDIDQQLELQAQTAMDAPPPSGWWSMWKGERAVRHIVCVHLAWSLYIVVYYGMLLNI 580
            |..  .:|.::..:|::..:....|    ........:...:.::.:...|  :.|.|....||:
Mouse   343 NKK--TIPLNLLNELQISGKKVAKA----SILDFCTNQHLFKVVLAIGCVW--FTVSYISFTLNL 399

  Fly   581 R--SFSRDHLYINTFFAGFSEMMGTFFGLFLILKTTRKW-LWTGLFNIVAGCIAYCGWLVPKPSV 642
            :  .|..| :|..........:......:.|:....||| |...||.:.:.|:    :|:..|.
Mouse   400 KMNDFGLD-VYFVQMVRSIVAVPARLCCIILLEYFGRKWALNLTLFLVTSMCL----FLLFLPQ- 458

  Fly   643 IGLDPNVALLMCSAMVSKMAISTTLSILTTCTVELVSDDKKKITSFSTICWARFWLLGAPFIGST 707
               :|...::: :.|:::.:::.||||....|.||:....:. |....:..|  |:.||  |.|.
Mouse   459 ---EPKSTIIL-TLMLAEFSMAGTLSIFFIYTAELLPTVLRS-TGLGMVSLA--WVAGA--ISSV 514

  Fly   708 VVFGQLIPQTA--FASLAILGGLC-TSLISSPRTHPISRPSSPAAQGTQNI--TSQFTIIDGMDN 767
            .:|.|...|..  |..|..:..|| :||:  |.|            |:|::  :.::.|.|.::.
Mouse   515 AIFKQTKTQLPIFFCCLCCVLALCFSSLV--PET------------GSQSLRDSIEYNIRDSIEP 565

  Fly   768 KGYSP--------------------TSKTIHS-------NSTI-LKLNTPQSNLPPQ 796
            |..:.                    |:.|:::       ||.: :.|..|:.:||.|
Mouse   566 KDRNKDVPMVIAEESMSDIVADSEVTNTTLNAVTFKPEENSLLNMTLEVPKMDLPVQ 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG44098	NP_001262264.1	2A0119	214..730	CDD:273328	127/542 (23%)
CG44098	NP_001262264.1	MFS	353..733	CDD:119392	94/390 (24%)
Slc22a14	NP_001032838.1	2A0119	59..553	CDD:273328	134/573 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843682
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704438at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850