Protein Alignment CG44098 and Slc22a3

DIOPT Version :10

• Sequence 1: NP_001262264.1
• Gene: CG44098 / 40590
• FlyBaseID: FBgn0264907
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_062103.1
• Gene: Slc22a3 / 29504
• RGDID: 3701
• Length: 551
• Species: Rattus norvegicus
• Alignment Length: 555
• Identity: 137/555 - (24%)
• Similarity: 250/555 - (45%)
• Gaps: 65/555 - (11%)

  Fly   214 GPWGKWQLRTVLLIFLCKIPSSWFMACIIFTAPAPRHGEFFCKPPHTIGAQNQTQWIKVSHPQKE 278
            |.:|::|.|..||:.|..:..::....::|....|.:  ::|:.|.......:..|
  Rat    12 GEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDY--YWCRGPRATALAERCAW--------- 65

  Fly   279 ESDDQEFSIDFCNVYQDA----QEHAHHYYNYENSDQEPRVWEKPL----HRNSNVIPCT-EFQH 334
             |.::|:::....::..|    |.|.|.|. .|:::....:...||    :|::.::||: ::::
  Rat    66 -SPEEEWNLTTPELHVPAERRGQGHCHRYL-LEDTNTSSELSCDPLAAFPNRSAPLVPCSGDWRY 128

  Fly   335 ESDYHSVVTQYDLVCSRDILVSVTQFFHLFGVLTGGILANQLLKYFSPRNVMLFGMITQIFCGNL 399
            ...:.::|:|:||||....::.:||.....|.|.|..    .|.|.:.|...|...:...|...:
  Rat   129 VETHSTIVSQFDLVCGNAWMLDLTQAILNLGFLAGAF----TLGYAADRYGRLIVYLISCFGVGI 189

  Fly   400 TGHVA----SYELHVFFRCLSAVCCAQMYTAGGQIMADITGGKYRTCVSTLFEQFWSIGVMMLPG 460
            ||.|.    ::.:.|.||.|..|.....:.....|:.:|.|.|.|..|..:.:.|:::|:::|||
  Rat   190 TGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPG 254

  Fly   461 VASFWSSWSHLYMAISWPT-VILIYLWQWIPDSPRWLIARGRTQDAKKILLECVEVNG----TGY 520
            :|.|..||..:.:|||.|: :.|:|.|. :|:||||||.|.:.:.|.:||....:.||    :.|
  Rat   255 IAYFTPSWQGIQLAISLPSFLFLLYYWV-VPESPRWLITRKQGEKALQILRRVAKCNGKHLSSNY 318

  Fly   521 NLPHDIDQQLELQAQTAMDAPPPSGWWSMWKGERAVRHIVCVHLAWSLYIVVYYGMLLNIRSFSR 585
            :.....|:  |:...:.:|         :.:..:..:..:.:..||....|||.|:::.: ....
  Rat   319 SEITVTDE--EVSNPSCLD---------LVRTPQMRKCTLILMFAWFTSAVVYQGLVMRL-GLIG 371

  Fly   586 DHLYINTFFAGFSEMMGTFFGLFLILKTTRKWLWTGLFNIVAGCIAYCGWLVPKPSVIGLDPNVA 650
            .:||::.|.:|..|:.|....|..|.:..|: |.....|||||........:|: .:..|...||
  Rat   372 GNLYMDFFISGLVELPGALLILLTIERLGRR-LPFAASNIVAGVSCLVTAFLPE-GIPWLRTTVA 434

  Fly   651 LLMCSAMVSKMAISTTLSILTTCTVELVSDDKKK--ITSFSTICWARFWLLGAPFIGSTVVFGQL 713
            .|      .::.|:....|:.....||.....:.  ::..|.:|  .|..:.|||:...:....|
  Rat   435 TL------GRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLC--DFGGIIAPFLLFRLAAIWL 491

  Fly   714 -IPQTAFASLA-ILGGLCTSLISSPRTHPISRPSS 746
             :|...|..|| :.|||...|   |.|..|:.|.:
  Rat   492 ELPLIIFGILASVCGGLVMLL---PETKGIALPET 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG44098	NP_001262264.1	MFS_SLC22	329..732	CDD:340875	108/416 (26%)
Slc22a3	NP_062103.1	2A0119	12..523	CDD:273328	137/553 (25%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O75751	284..288		2/3 (67%)