DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG44098 and Slc22a20

DIOPT Version :9

Sequence 1:	NP_001262264.1	Gene:	CG44098 / 40590	FlyBaseID:	FBgn0264907	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_001381833.1	Gene:	Slc22a20 / 293686	RGDID:	1311460	Length:	556	Species:	Rattus norvegicus

Alignment Length:	615	Identity:	134/615 - (21%)
Similarity:	247/615 - (40%)	Gaps:	108/615 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 VDAVGQITGPWGKWQL-RTVLLIFLCKIPSSWFMACII----FTAPAPRHGEFFCKPP--HTIGA 263
            :||:|.:    |::|| .|.||:..|.:     :||..    |||.||.|   .|:.|  :|...
  Rat     7 LDALGGV----GRFQLVYTALLLLPCGL-----LACHTFLQNFTAAAPPH---HCQHPANYTEAT 59

  Fly   264 QNQT-QWIKVSHPQKEESDDQEFSIDFCNVYQDAQ------EHAHHYYNYENSDQEPRVWEKPLH 321
            .|.: .|::.:.|..:....:.     |..|.:.|      ..:.|....|.. ::..|:::
  Rat    60 TNDSGAWLRATIPLNQHGVPEP-----CQRYTEPQWALLEPNTSSHGVATEGC-KDGWVYDR--- 115

  Fly   322 RNSNVIPCTEFQHESDYHSVVTQYDLVCSRDILVSVTQFFHLFGVLTGGILANQLLKYFSPRNVM 386
               ::.|.|          :|.::||||....|..:.|..::.|||.|..|...|......:..:
  Rat   116 ---SIFPST----------IVMEWDLVCEARTLRDLAQSIYMSGVLVGAALFGSLADRLGRKAPL 167

  Fly   387 LFGMITQIFCGNLTGHVASYELHVFFRCLSAVCCAQMYTAGGQIMADITGGKYRTCVSTLFEQFW 451
            ::..:.....|.:|.:|.|:..:..||.|..:..:.:......::.:....:.||....|....:
  Rat   168 VWSYLQLAVSGAVTAYVGSFSAYCIFRFLMGMTFSGIILNSLSLVVEWMPTRGRTVAGILLGFSF 232

  Fly   452 SIGVMMLPGVASFWSSWSHLYMAISWP-TVILIYLWQWIPDSPRWLIARGRTQDAKKILLECVEV 515
            ::|.::|.|||.....|..|..|:|.| .|..:|.| |:|:|.|||:..|:.|.|.:.|.:...:
  Rat   233 TLGQLILAGVAYLIRPWRWLQFAVSAPFLVFFLYSW-WLPESSRWLLLHGKAQQAVQNLRKVAMM 296

  Fly   516 NG---TGYNLPHDIDQ---QLEL----QAQTAMDAPPPSGWWSMWKGERAVRHIV-CVHLAWSLY 569
            ||   .|..|..::..   |.|.    .:.:.:|.....|          :|.:. |:.:.|...
  Rat   297 NGRKAEGERLTIEVVSSYIQNEFASVRTSNSILDLFRTPG----------IRKVTCCLMMVWFSN 351

  Fly   570 IVVYYGMLLNIRSFSRDHLYINTFFAGFS-EMMGTFFGLF---LILKTTRKWLWTG------LFN 624
            .|.|||:.::::.|            |.| .::...||:.   .:|..|...::.|      .|.
  Rat   352 SVAYYGLAMDLQKF------------GLSIYLVQALFGIIDIPAMLVATTTMIYVGRRATVSSFL 404

  Fly   625 IVAGCIAYCGWLVPKPSVIGLDPNVALLMCSAMVSKMAISTTLSILTTCTVELVSDDKKKI-TSF 688
            ::||.:......||       :....|....|.:.|..::::...:...|.||...:.::: ..|
  Rat   405 VLAGLMVIANMFVP-------EDLQTLRTVQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGF 462

  Fly   689 STICWARFWLLGAPFIGSTVVFGQLIPQTAFASLAILGGLC-----TSLISSPRTHPISRPSSPA 748
            :::. ||...|.||.|.:......::|..:|.:.::|.|:.     |...:.|....|:...|..
  Rat   463 ASVN-ARLGGLAAPLITTLGEISPVLPPVSFGATSVLAGMAVICFLTETRNVPLVETIAAMESRV 526

  Fly   749 AQG-TQNITSQFTIIDGMDNKGYSPTSKTI 777
            .:| ::..|.|......:...|..|..:||
  Rat   527 KEGHSKRDTEQKNEEISLQQLGAPPLKETI 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG44098	NP_001262264.1	2A0119	214..730	CDD:273328	120/557 (22%)
CG44098	NP_001262264.1	MFS	353..733	CDD:119392	87/407 (21%)
Slc22a20	NP_001381833.1	MFS_SLC22A6_OAT1_like	103..508	CDD:341004	95/452 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347014
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704438at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940