DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG44098 and slc22a5

DIOPT Version :9

Sequence 1:	NP_001262264.1	Gene:	CG44098 / 40590	FlyBaseID:	FBgn0264907	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	XP_021324939.1	Gene:	slc22a5 / 100000685	ZFINID:	ZDB-GENE-091012-1	Length:	549	Species:	Danio rerio

Alignment Length:	577	Identity:	133/577 - (23%)
Similarity:	225/577 - (38%)	Gaps:	125/577 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 VGQITGPWGKWQLRTVLLIFLCKIPSSWFMACIIFTAPAPRHGEFFCKPPHTIGAQNQTQWIKVS 273
            :|| |||   :.:|...|:.|..|.:......|:|.|.:|.|.   |:    :.......|::.|
Zfish    11 LGQ-TGP---FFIRLFCLLNLIYISTGLHGLYIVFVAASPAHR---CR----VDVNLTEDWLEAS 64

  Fly   274 HPQKEESDDQEFSIDFCNVYQDAQEHAHHYYNYENSD-QEPRVWEKPLHRNSNV----------- 326
            .|.:..|                           |.| |..:.|...|...:|:
Zfish    65 APTETLS---------------------------NGDLQVSQCWRYSLQTLTNLSGQGYSPGQIN 102

  Fly   327 ---IP---CTE-FQHESD-YHS-VVTQYDLVCSRDILVSVTQFFHLFGVLTGGILANQLLKYFSP 382
               ||   |.: :.:.:| ||| :|:::||||..:..|.:.......|.|.|.|::.||...|.
Zfish   103 ITDIPRERCEDGWVYSADVYHSTIVSEWDLVCDSEWRVPLASSTLYMGYLLGSIVSGQLSDRFG- 166

  Fly   383 RNVMLFG--------MITQ-------IFCGNLTGHVASYELHVFFRCLSAVCCAQMYTAGGQIMA 432
            |..:|||        |..|       ||| .|...:.::::.::...         :..|.::::
Zfish   167 RKKVLFGSLAAEALLMFAQSFSPSWLIFC-VLYFFIGAFQISLYITA---------FVLGNEVLS 221

  Fly   433 DITGGKYRTCVSTL--FEQFWSIGVMMLPGVASFWSSWSHLYMAISWPTVILIYLWQWIPDSPRW 495
                |..|...:||  |..: .:|.|:||.||.....|..|...:|..||:.|.||..||:||||
Zfish   222 ----GSLRVLFTTLGAFLHY-CVGYMLLPWVAFAIRHWRTLLRVLSGLTVVYIPLWWLIPESPRW 281

  Fly   496 LIARGRTQDAKKILLECVEVNGTGYNLPHDIDQQLELQ-------AQTAMDAPPPSGWWSMWKGE 553
            |:::|..|:::.||.:....|..  ..|..|.:|.:::       ..:|:|....|.
Zfish   282 LLSQGHVQESEAILRDAARKNRV--PAPEVIFKQSQIKEAAFQKSKYSALDVLRTSN-------- 336

  Fly   554 RAVRH--IVCVHLAWSLYIVVYYGMLLNIRSFSRDHLYINTFFAGFSEMMGTFFGLFLILKTTRK 616
              :|.  .:|: |.|....:.|:|:.||..:.|.|. ::|.|.:..:|:.......||:....|:
Zfish   337 --IRRTTFMCL-LLWMAINIGYFGLSLNTTNLSGDP-FLNCFLSAVTEVPAYIVSTFLLKSCPRR 397

  Fly   617 WLWTGLFNIVAGCIAYCGWLVPKPSVIGLDPNVALLMCSAMVSKMAISTTLSILTTCTVELVSDD 681
            .:.:. |.::.|.......|:|       |....|.:...|..|...:.:.:::...|.||....
Zfish   398 PVLSA-FLVIGGGFLLLVQLIP-------DRLQTLALALEMAGKFGFTMSFTVVYIYTAELYPTV 454

  Fly   682 KKKITSFSTICWARFWLLGAPFIGSTVVFGQLIPQTAFASLAILGGLCTSLISSPRT 738
            .:.:........||...:.||:|.....|.:.:|.....||.|...|....:  |.|
Zfish   455 LRNLGMGMCSSAARIGSITAPYIIFLGTFNRHLPYVLMGSLTITASLANLFL--PET 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG44098	NP_001262264.1	2A0119	214..730	CDD:273328	128/562 (23%)
CG44098	NP_001262264.1	MFS	353..733	CDD:119392	94/405 (23%)
slc22a5	XP_021324939.1	Sugar_tr	12..516	CDD:331684	133/576 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588413
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840