Protein Alignment BCAM and bcam

DIOPT Version :10

• Sequence 1: NP_005572.2
• Gene: BCAM / 4059
• HGNCID: 6722
• Length: 628
• Species: Homo sapiens
• Sequence 2: NP_001352817.1
• Gene: bcam / 767689
• ZFINID: ZDB-GENE-060929-620
• Length: 611
• Species: Danio rerio
• Alignment Length: 630
• Identity: 205/630 - (32%)
• Similarity: 309/630 - (49%)
• Gaps: 77/630 - (12%)

Human    18 LLAVLLAAHPDAQAEVRLSVPPLVEVMRGKSVILDCT-PTGTHDHYMLEWFLTDRSGARPRLASA 81
            ||||:|..   ..|.|.:.|.|.:.|::|.:|:|.|| .|.......::||:....|.|.::|..
Zfish    15 LLAVVLQV---CLASVTVKVNPEMHVLKGDTVMLPCTYTTSAEAAVAVQWFIEFADGGRKQVAYK 76

Human    82 EMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAK 146
            ...||:.. |..|.      |.::....|.:::..|.|.:.::|.|.||..||||:...:.||:.
Zfish    77 SSVGSDAG-TFTDR------YTIEKDMSLNISQVTVDDHKKFICQVTAGPVGTAESATEVKVFSA 134

Human   147 PEATEVSPNKGTLSVME--DSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTV 209
            ||...|.||...:.|..  .|:.|:..|.||||:|.|:|.|:::...|....:...:.||....|
Zfish   135 PEKPMVVPNPQKIFVDSSISSSAEVGKCISRNGHPEPRIIWFKDDNPLPEEKKKTEKTYMIHFLV 199

Human   210 REASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSP 274
            :|||||.:|||.||:.|.|.|..:.:||...|::|:.:..:..|..|:::|.|.||:|.|.|.:
Zfish   200 KEASGLYTLTSMLYMHLTKADAKSVYHCIVEYTMPDNQIKQESSDNFNISLQYSTENVFFKVKN- 263

Human   275 STPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRV 339
               .|.::|||.|.:.|..||:|.|::..|:     .|.|...|.|.|..:.:||..||||.|..
Zfish   264 ---EGPIKEGDDVVMQCETDGNPQPQFDFFK-----GEKLLEGLGGTLKKKSITREDSGTYKCEA 320

Human   340 EDYDAADDVQLSKTLELRVAYLD-------PLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWT 397
            .||:|...|||.|||.:.|.|:|       ||.:|:|..:.|        .|.........|:||
Zfish   321 MDYEADSKVQLHKTLNINVHYIDITVEPEGPLVVSKGDHVEL--------QCKAKASEAHTLQWT 377

Human   398 KDSTPLGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGS 462
            |||..|.:..:.:..|:|....|.|||..::|:||.|.:..|.|:.|:|.||: .|.::...|
Zfish   378 KDSKELSNTGVFAKESVTLADGGVYVCVGAVPSVPGLQKQVNITVNVKGQPEI-DAPVKGLVD-- 439

Human   463 WREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNP 527
             :||..|||.|||.|||.|:..|:..|   .|.:..:...|.|::||:.|:|:.:||:.|||.|.
Zfish   440 -KEGGMVTLNCSALGHPAPQFIWTPSG---KESVTVKGNRVISTVTLEATAAVLKDGVICEAYNT 500

Human   528 HGNKRHVFH-------------------FGTVSPQTSQAGVAVMAVAVSVGLLLLVVAVFYCVRR 573
            ||.....|.                   |.||..:...:...|:||.|.|.|||::||..:.:.:
Zfish   501 HGRDSKNFEVKLDQAKPTPANSDRGNPDFKTVEGKQGGSSSVVIAVVVCVLLLLILVASLFFLNK 565

Human   574 KGGPCCRQRREKGAPPPG---------EPGLSHSGSEQPEQTGLL 609
            ||...|.::.:|.....|         :|     ..:..|:.|||
Zfish   566 KGKLGCGKKDQKEVASGGVKDNIVVEIKP-----SEKSKEEAGLL 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BCAM	NP_005572.2	V-set	37..143	CDD:462230	30/106 (28%)
		C2-set_2	151..248	CDD:400489	36/98 (37%)
		Ig strand C	182..186	CDD:409416	1/3 (33%)
		IG_like	280..358	CDD:214653	31/77 (40%)
		Ig strand B	287..291	CDD:409353	1/3 (33%)
		Ig strand C	300..304	CDD:409353	0/3 (0%)
		Interaction with laminin alpha5	309..312		0/2 (0%)
		Ig strand E	320..324	CDD:409353	2/3 (67%)
		Ig strand F	334..339	CDD:409353	3/4 (75%)
		Ig_2	363..437	CDD:464026	23/73 (32%)
		Ig_3	464..526	CDD:464046	26/61 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	579..628		8/40 (20%)
bcam	NP_001352817.1	Ig	27..131	CDD:472250	31/110 (28%)
		Ig strand B	43..47	CDD:409353	2/3 (67%)
		Ig strand C	59..62	CDD:409353	0/2 (0%)
		Ig strand E	96..100	CDD:409353	1/3 (33%)
		Ig strand F	110..115	CDD:409353	1/4 (25%)
		Ig strand G	124..127	CDD:409353	1/2 (50%)
		Ig	138..234	CDD:472250	35/95 (37%)
		Ig strand C	172..176	CDD:409353	1/3 (33%)
		Ig strand E	191..195	CDD:409353	1/3 (33%)
		Ig_3	267..320	CDD:464046	22/57 (39%)
		Ig_2	351..422	CDD:464026	24/78 (31%)
		Ig_3	428..499	CDD:464046	30/77 (39%)