Protein Alignment BCAM and sns

DIOPT Version :10

• Sequence 1: NP_005572.2
• Gene: BCAM / 4059
• HGNCID: 6722
• Length: 628
• Species: Homo sapiens
• Sequence 2: NP_001036532.1
• Gene: sns / 44097
• FlyBaseID: FBgn0024189
• Length: 1542
• Species: Drosophila melanogaster
• Alignment Length: 665
• Identity: 149/665 - (22%)
• Similarity: 229/665 - (34%)
• Gaps: 214/665 - (32%)

Human    17 LLLAVLLAAHP---DAQAEVRLSVPPLVEVMRGKSVILDCTPTG-------THDHYMLEWFLTDR 71
            ||..::||:.|   .||.:...:.|..::|:.|...::.|....       |.|.:.|.:
  Fly    54 LLAVIVLASAPVPSHAQQQKFRTTPHDLQVLEGAEAMMRCEVANVAGAVQWTKDGFALGF----- 113

Human    72 SGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQG--RLVLAEAQVGDERDYVCVVRAGAAGT 134
                    ||.:.|......:.|.:          ||  .|.::.|.:.|:.||.|.|......:
  Fly   114 --------SAVIPGFPRYSVLGDRK----------QGIYNLRISNASINDDADYQCQVGPARLNS 160

Human   135 A-EATARLNVFAKPEATEVS--PNKGTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPV 196
            | .|.|:|.|.:.|.:.|:.  .:...:.|.|:...:: .|...|..||.:|.|||..      |
  Fly   161 AIRANAKLTVISPPASIEIKGYSHNSKVEVRENQDLQL-KCIVANAKPAAQIVWYRGN------V 218

Human   197 EMNPEGYMTSRTVREASG-LLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRL--DSP---T 255
            |..||  ....||.|::. ..:.||:|.|:...||....:.|.|       ||..|  |.|   |
  Fly   219 EYKPE--KREDTVEESTAKRFTTTSSLKLKPGPDDDYTEYTCQA-------RHKALSPDMPMRAT 274

Human   256 FHLTLHYPTEHVQFWVGSPSTP------AG-WVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEV 313
            ..|::.||          |..|      || .:|.|.||:|:||..|...|...::.....|..:
  Fly   275 VQLSVLYP----------PGPPYIEGYSAGETLRRGQTVELMCRSRGGNPPAQLIWYKNGSQIRM 329

Human   314 -------LNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLEL-----RVAYLDPLEL 366
                   |:.|:   .|...........:.|...:..:.:.::....|.:     .|..:.|.|.
  Fly   330 AYRTSGRLSENI---YTFTAEAGDNKARFRCEASNVMSQNPLKAEVELSVLFAPTHVTVMGPTEA 391

Human   367 SEGKVLSL-----PLNSSAVVNCSVHG----------LPTPALRWTKDST--------------- 401
            ..|.::.|     |.|..|.:...|.|          :.:|...||..|.
  Fly   392 RVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRNATSKTIVSPEGGWTTTSNITAVVEPNKRSLVVI 456

Human   402 --------------------------PL-----------------------GDGPMLSL------ 411
                                      ||                       |..|:.:|
  Fly   457 CHGLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKND 521

Human   412 ---------------SSITF-----DSNGTYVCEA--SLPTVPVLSRTQNFTLLVQGSPELKTAE 454
                           :.||.     |:...|.|||  |...:|:.   |:.||.|..:||.....
  Fly   522 KRINSVIRAADKSVSAEITILANVSDNQAQYRCEASNSATEIPLF---QSTTLSVHFAPETVKIR 583

Human   455 IEPKADGSWREGDEVTLIC-SARGHPDPKLSWSQLGGSPAEPI-----PGRQGWVSSSLTLK--V 511
            |||:   ..|.|.|.|:|| |:..:|..||||.: .|.|.|.|     ||..|...|:|..:  |
  Fly   584 IEPE---ELRPGMEATIICDSSSSNPPAKLSWWK-DGIPIEGINNTSKPGLWGGTVSTLEFRVNV 644

Human   512 TSALSRDGISCEASN 526
            |..::....:|:::|
  Fly   645 TQEMNGQVYTCQSAN 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BCAM	NP_005572.2	V-set	37..143	CDD:462230	24/115 (21%)
		C2-set_2	151..248	CDD:400489	26/99 (26%)
		Ig strand C	182..186	CDD:409416	1/3 (33%)
		IG_like	280..358	CDD:214653	15/89 (17%)
		Ig strand B	287..291	CDD:409353	2/3 (67%)
		Ig strand C	300..304	CDD:409353	0/3 (0%)
		Interaction with laminin alpha5	309..312		1/2 (50%)
		Ig strand E	320..324	CDD:409353	0/3 (0%)
		Ig strand F	334..339	CDD:409353	1/4 (25%)
		Ig_2	363..437	CDD:464026	27/180 (15%)
		Ig_3	464..526	CDD:464046	24/69 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	579..628
sns	NP_001036532.1	Ig	73..170	CDD:472250	24/119 (20%)
		Ig strand B	89..93	CDD:409559	0/3 (0%)
		Ig strand C	101..105	CDD:409559	0/3 (0%)
		Ig strand E	130..138	CDD:409559	3/17 (18%)
		Ig strand F	148..153	CDD:409559	3/4 (75%)
		Ig	173..279	CDD:472250	34/121 (28%)
		Ig strand B	196..200	CDD:409418	0/4 (0%)
		Ig strand C	210..214	CDD:409418	1/3 (33%)
		Ig strand E	241..245	CDD:409418	2/3 (67%)
		Ig strand F	255..260	CDD:409418	1/4 (25%)
		Ig strand G	272..275	CDD:409418	0/2 (0%)
		Ig_3	285..361	CDD:464046	17/78 (22%)
		Ig	377..>457	CDD:472250	14/79 (18%)
		Ig strand B	397..401	CDD:409418	1/3 (33%)
		Ig strand C	411..415	CDD:409418	0/3 (0%)
		Ig strand E	440..444	CDD:409418	1/3 (33%)
		Ig	477..560	CDD:472250	12/82 (15%)
		Ig strand B	499..504	CDD:409418	0/4 (0%)
		Ig strand C	514..518	CDD:409418	1/3 (33%)
		Ig strand E	537..541	CDD:409418	1/3 (33%)
		Ig strand F	551..556	CDD:409418	2/4 (50%)
		Ig	584..666	CDD:472250	28/80 (35%)
		Ig strand B	595..599	CDD:409416	1/3 (33%)
		Ig strand C	609..613	CDD:409416	3/3 (100%)
		Ig strand E	636..642	CDD:409416	2/5 (40%)
		Ig strand F	652..657	CDD:409416	1/4 (25%)
		Ig strand G	667..670	CDD:409416
		Ig	678..767	CDD:472250
		Ig strand B	696..700	CDD:409353
		Ig strand C	710..714	CDD:409353
		Ig strand E	733..737	CDD:409353
		Ig strand F	747..752	CDD:409353
		Ig_3	772..847	CDD:464046
		Ig	881..963	CDD:472250
		Ig strand B	885..888	CDD:409353
		Ig strand C	897..901	CDD:409353
		Ig strand E	929..933	CDD:409353
		Ig strand F	943..948	CDD:409353
		FN3	967..1051	CDD:238020