DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BCAM and beat-IIa

DIOPT Version :9

Sequence 1:	NP_005572.2	Gene:	BCAM / 4059	HGNCID:	6722	Length:	628	Species:	Homo sapiens
Sequence 2:	NP_001287375.1	Gene:	beat-IIa / 42086	FlyBaseID:	FBgn0038498	Length:	431	Species:	Drosophila melanogaster

Alignment Length:	392	Identity:	80/392 - (20%)
Similarity:	130/392 - (33%)	Gaps:	114/392 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   277 PAGWVREGDTVQLLCRGDGSPSPEYT--LFRLQDE-----QEEVLNVNL-----------EGNLT 323
            ||  ||.|..|.|.|..|...:|.|:  .:|.|.|     ..|..|..:           ..|.|
  Fly    78 PA--VRRGQHVVLRCMYDLDGAPLYSAKFYRGQLEFYRYTPGEFPNTKVFPFPGIHVDVSSSNAT 140

Human   324 ---LEGVTRGQSGTYGCRV-------EDYDAADDVQLSKTLELR-VAYLDPLELSEGKVLSLPLN 377
               |..|..|.||.:.|.|       ....|.|.:|:.:..|.| ..:.:......|.||.
  Fly   141 QVLLRNVGFGLSGNFSCEVTADAPLFSTATAVDTMQVVELPEKRPQVFTEHTRYEPGDVLR---- 201

Human   378 SSAVVNCSVHGLPTPALRWTKDSTPLGDGPMLSLSSITFDSNG---TYVCEASLPTVPVLSRTQ- 438
                .||               |||    |....:.:||..|.   |:|....:.|:..|..|:
  Fly   202 ----ANC---------------STP----PSRPRAELTFTINNMVITHVDTEYIRTIDNLIATRI 243

Human   439 NFTLLVQGSPELKTAEIEPK-------ADGSWREGDEV----------TLICSAR-GHPDPKLSW 485
            :..:.:||   :..:.:.|.       .:..:..|..|          .|.|||: |....:...
  Fly   244 SLKMQLQG---IHFSSVNPAIYNNVYGLNSVYGHGGPVYAPNSNPGGLLLRCSAQIGDLYQEYKE 305

Human   486 SQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAGVA 550
            .:||....:|:|.|       :||...::|..                 |.....|...|.|...
  Fly   306 IELGTPQKDPVPAR-------VTLSSDTSLKN-----------------FFSSYFSTSASAASRL 346

Human   551 VMAVAVSVGLLLLVVAVFYCVRRKGGPCCRQRREKGAPPPGEPG--LSHSGS-EQPEQTGLLMGG 612
            :..|.::..::.::.::|..:.....||....::    |..:.|  :.||.. .:|::...|:..
  Fly   347 LPGVYMAPLIMAMLASLFRLIEAAFEPCDASSQD----PQSQTGHSMEHSKERREPKERPALVSS 407

Human   613 AS 614
            .|
  Fly   408 CS 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BCAM	NP_005572.2	Ig	37..143	CDD:325142
		C2-set_2	151..248	CDD:311910
		IG_like	280..358	CDD:214653	28/106 (26%)
		Interaction with laminin alpha5	309..312		1/7 (14%)
		IGc2	377..427	CDD:197706	11/52 (21%)
		Ig_3	464..526	CDD:316449	15/72 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..628		7/39 (18%)
beat-IIa	NP_001287375.1	PTZ00491	<209..>261	CDD:240439	11/54 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910