Protein Alignment BCAM and side-IV

DIOPT Version :10

• Sequence 1: NP_005572.2
• Gene: BCAM / 4059
• HGNCID: 6722
• Length: 628
• Species: Homo sapiens
• Sequence 2: NP_001034052.2
• Gene: side-IV / 41657
• FlyBaseID: FBgn0038156
• Length: 1001
• Species: Drosophila melanogaster
• Alignment Length: 562
• Identity: 124/562 - (22%)
• Similarity: 197/562 - (35%)
• Gaps: 128/562 - (22%)

Human    39 PL--VEVMRGKSVILDC--TPTGTHDH-YMLEWFLTDRSGARPRLASAEMQGSEL-------QVT 91
            ||  |:.:.|:..:|.|  :|....|. ||:.||   |.|....:.:.:::|.:.       ..|
  Fly    77 PLTTVQGVLGRQAMLPCDISPQERDDAVYMVLWF---REGDGEPIYNFDVRGRQFGQARLWSSPT 138

Human    92 MHDTRGR----SPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEV 152
            ...||..    :.|.||.      :...::.||..|.|.|....:.|......|.|...|:...:
  Fly   139 AFGTRAHFSSTTHPAQLK------IDNIRIEDEGVYRCRVDFRNSPTRNLKINLTVIVPPDRPVI 197

Human   153 -SPNK----GTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREA 212
             ..|:    |.:....:....:.:|....|.|.|.:|||.:...::...|..|:|    :|:...
  Fly   198 YGQNRHEKAGNVESFSEGNDIVLSCEVSGGRPRPNVTWYLDNTAIDESFEQRPDG----KTINHL 258

Human   213 SGLLSLTSTLYLRLRKDDRDASFHCAA---HYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSP 274
            |         |..:.:...::...|.|   :.:.|..|...||.....:.:|..|:.
  Fly   259 S---------YPNVGRQHLNSRLMCVASNTNLTPPNNRVVILDVNLKPIAVHILTKD-------- 306

Human   275 STPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVL--NVNLEGNLTLEGVT----RGQSG 333
                .:|....|..:.|:..||..|....:....:|.:.|  |.|...|.:|..:|    |...|
  Fly   307 ----RFVSADRTYDVECKSSGSKPPALITWWKGSKQLKKLTKNFNEPDNQSLSILTFTPGREDDG 367

Human   334 TY-GCRVE----DYDAADD-----VQLSKTLELRV-AYLDPLELSEGKVLSLPLNSSAVVNCSVH 387
            .| .||.|    |..|.:|     |....|..|:: :.|:|.::.||        ..|...|.|.
  Fly   368 KYLTCRAENQFIDGSAIEDKWRLIVHYQPTTTLKIGSSLNPDDIKEG--------DDAYFECIVL 424

Human   388 GLPTP-ALRWTKDSTPL----GDGPMLS-----LSSITFDSNGTYVC-----EASLPTVPVLSRT 437
            ..|.| .:.|..:...|    ..|.:||     |.|::..|.|.|.|     |...|:.||..|.
  Fly   425 ANPKPYKMSWFHNGKELQHNISAGVILSDQSLVLQSVSRASAGDYTCLAVNSEGKGPSNPVTLRI 489

Human   438 QNFTLLVQGSPEL------KTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPI 496
            :...:......||      :|..::.:.|.|               .|.....|:.........:
  Fly   490 RYAPICATDHEELLGALKHETLPLKCEVDSS---------------PPADSFQWTFNSSGEQTEL 539

Human   497 PGRQGWVSSSLT----LKVTSALSRD--GISCEASNPHGNKR 532
            |.|   :.||.|    |..|.:...|  .|||.|.|..|.::
  Fly   540 PAR---LHSSETGMSRLNYTPSTDLDYGTISCWAKNSIGTQK 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BCAM	NP_005572.2	V-set	37..143	CDD:462230	28/119 (24%)
		C2-set_2	151..248	CDD:400489	18/104 (17%)
		Ig strand C	182..186	CDD:409416	1/3 (33%)
		IG_like	280..358	CDD:214653	25/93 (27%)
		Ig strand B	287..291	CDD:409353	0/3 (0%)
		Ig strand C	300..304	CDD:409353	0/3 (0%)
		Interaction with laminin alpha5	309..312		1/2 (50%)
		Ig strand E	320..324	CDD:409353	1/3 (33%)
		Ig strand F	334..339	CDD:409353	2/5 (40%)
		Ig_2	363..437	CDD:464026	23/88 (26%)
		Ig_3	464..526	CDD:464046	14/67 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	579..628
side-IV	NP_001034052.2	V-set	79..188	CDD:462230	26/117 (22%)
		Ig	210..281	CDD:472250	15/83 (18%)
		Ig strand B	218..222	CDD:409353	0/3 (0%)
		Ig strand C	232..236	CDD:409353	1/3 (33%)
		Ig	<317..392	CDD:472250	20/74 (27%)
		Ig strand C	329..333	CDD:409353	0/3 (0%)
		Ig strand E	355..359	CDD:409353	0/3 (0%)
		Ig strand F	369..374	CDD:409353	2/4 (50%)
		Ig strand G	385..388	CDD:409353	1/2 (50%)
		Ig	411..479	CDD:472250	19/75 (25%)
		Ig strand B	417..421	CDD:409353	1/3 (33%)
		Ig strand C	431..435	CDD:409353	0/3 (0%)
		Ig strand E	454..458	CDD:409353	0/3 (0%)
		Ig strand F	468..473	CDD:409353	2/4 (50%)
		Ig	494..576	CDD:472250	20/99 (20%)
		Ig strand B	511..515	CDD:409353	0/3 (0%)
		Ig strand C	525..529	CDD:409353	0/3 (0%)
		Ig strand E	551..555	CDD:409353	1/3 (33%)
		Ig strand F	566..570	CDD:409353	3/3 (100%)
		fn3	593..675	CDD:394996