Protein Alignment BCAM and side-II

DIOPT Version :10

• Sequence 1: NP_005572.2
• Gene: BCAM / 4059
• HGNCID: 6722
• Length: 628
• Species: Homo sapiens
• Sequence 2: NP_001400995.1
• Gene: side-II / 3346206
• FlyBaseID: FBgn0259213
• Length: 1067
• Species: Drosophila melanogaster
• Alignment Length: 574
• Identity: 124/574 - (21%)
• Similarity: 206/574 - (35%)
• Gaps: 117/574 - (20%)

Human    41 VEVMRGKSVILDCTPTGTHDH-YMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPP--- 101
            ::.:.||||.|.|..|...|: ||:.||   |..|...|.|.:::..|   :....|..|.|
  Fly    57 IDAVEGKSVSLPCPITEPLDNVYMVLWF---RDNAGIPLYSFDVRDKE---SREQPRHWSAPEVF 115

Human   102 -----YQLDSQ-GRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKG--- 157
                 :..||| ..|.:.:.:..|:..|.|.|....:.|......|:|...||...:....|
  Fly   116 GSRAKFHFDSQPATLEIKDIKRHDQGIYRCRVDFRTSQTQSFRFNLSVIILPEQPIIMDRWGRQL 180

Human   158 ---TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLT 219
               .|...::....:.||....|.|.|::.|..||..::...|.|             ||.:...
  Fly   181 NGTQLGPKQEGDDIVITCRVVGGRPQPQVRWLVNGLLVDNQNEHN-------------SGDVIEN 232

Human   220 STLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSP---TFHLTLHYPTEHVQFWVGSPSTPAGWV 281
            ..|:..::::|.::.|.|.|       .:.:||.|   :|.|.:|.....|:..    ..|:..:
  Fly   233 RLLWPSVQRNDLNSVFTCQA-------LNTQLDKPKEKSFILDMHLKPLVVKIL----EPPSSMI 286

Human   282 REGDTVQLLCRGDGS-PSPEYTLFR----LQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVED 341
            .: ...::.|...|| |:...|.::    |:..::::...:....|:....|.....:..||.|:
  Fly   287 AD-RRYEVSCESSGSRPNAIITWYKGKRQLRRTKDDISKNSTRSELSFVPTTDDDGKSITCRAEN 350

Human   342 YDAADDVQLSKTLELRVAY-----------LDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALR 395
            .: .:.:.|....:|.|.|           |.|.::.||        ......|.|...|    :
  Fly   351 PN-VNGLYLETMWKLNVVYPPLVTLRLGSTLTPDDIKEG--------DDVYFECHVQSNP----Q 402

Human   396 WTK--------------DSTPLGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQG 446
            |.|              .:..:.....|.|..||....|.|.|.|.......:|  ....|.|:.
  Fly   403 WRKLLWLHNGIHLEHNTSARVIRSNQSLVLQKITKHYAGNYACSAINDEGETVS--NQLPLRVKY 465

Human   447 SPELKTAE----IEPKADGSWREGDEVTLICSARGHPDPK-LSWSQLGGSPAEPIPGRQGWVSSS 506
            :|..|.|:    |....|      :.|.::|..:..|.|: ..|..........:...:..|:.|
  Fly   466 TPMCKHADRVILIGASKD------ETVEVVCEIQADPPPRTFRWKFNNSGETLDVGSERFSVNGS 524

Human   507 LT-LKVTSALSRD--GISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMAVAVS 557
            .: ||.|....:|  .:||.|||..|.::|        |...|..:|.:..|||
  Fly   525 RSILKYTPVTDQDYGTLSCWASNEVGTQQH--------PCLFQVVLAALPNAVS 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BCAM	NP_005572.2	V-set	37..143	CDD:462230	30/111 (27%)
		C2-set_2	151..248	CDD:400489	19/102 (19%)
		Ig strand C	182..186	CDD:409416	0/3 (0%)
		IG_like	280..358	CDD:214653	13/82 (16%)
		Ig strand B	287..291	CDD:409353	0/3 (0%)
		Ig strand C	300..304	CDD:409353	1/3 (33%)
		Interaction with laminin alpha5	309..312		0/2 (0%)
		Ig strand E	320..324	CDD:409353	1/3 (33%)
		Ig strand F	334..339	CDD:409353	1/4 (25%)
		Ig_2	363..437	CDD:464026	17/87 (20%)
		Ig_3	464..526	CDD:464046	14/65 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	579..628
side-II	NP_001400995.1	V-set	55..163	CDD:462230	30/111 (27%)
		Ig_3	190..254	CDD:464046	17/83 (20%)
		Ig	<292..366	CDD:472250	13/74 (18%)
		Ig strand B	292..295	CDD:409418	0/2 (0%)
		Ig strand C	305..309	CDD:409418	1/3 (33%)
		Ig strand E	329..333	CDD:409418	1/3 (33%)
		Ig strand F	343..348	CDD:409418	1/4 (25%)
		Ig strand G	359..362	CDD:409418	0/2 (0%)
		Ig	382..457	CDD:472250	17/88 (19%)
		Ig strand B	391..395	CDD:409405	0/3 (0%)
		Ig strand C	405..409	CDD:409405	1/3 (33%)
		Ig strand E	428..432	CDD:409405	1/3 (33%)
		Ig strand F	442..447	CDD:409405	2/4 (50%)
		Ig	486..554	CDD:409353	17/67 (25%)
		Ig strand B	486..490	CDD:409353	1/3 (33%)
		Ig strand C	500..504	CDD:409353	0/3 (0%)
		Ig strand E	526..530	CDD:409353	1/3 (33%)
		Ig strand F	540..545	CDD:409353	2/4 (50%)