DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BCAM and kirre

DIOPT Version :9

Sequence 1:	NP_005572.2	Gene:	BCAM / 4059	HGNCID:	6722	Length:	628	Species:	Homo sapiens
Sequence 2:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	613	Identity:	140/613 - (22%)
Similarity:	229/613 - (37%)	Gaps:	99/613 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    46 GKSVILDC---TPTGTHDHYMLEWFLTDRS-GARPRLASAE---MQGSELQVTMHDTRGRSPPYQ 103
            |..|.|.|   ...|.     |:|...|.. |....|:..|   |.||       |..|   .:.
  Fly    96 GSRVTLPCRVMEKVGA-----LQWTKDDFGLGQHRNLSGFERYSMVGS-------DEEG---DFS 145

Human   104 LDSQGRLVLAEAQVGDERDYVCVV---RAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDS 165
            ||      :....:.|:..|.|.|   ..|..|.....|:|.|...|||.:::  :|...|..:.
  Fly   146 LD------IYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKIT--QGDYLVTTED 202

Human   166 AQEIATCNSRNGNPAPKITWYRN-GQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKD 229
            .:....|.|:.|.||.:|||... |..|...:|...|....||.:       :..|.|.|..:|:
  Fly   203 REIELECVSQGGKPAAEITWIDGLGNVLTKGIEYVKEPLADSRRI-------TARSILKLAPKKE 260

Human   230 DRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGD 294
            ..:.:|.|.|..:...    ...|....|.:.|..:.:...||. :...|.:.||..|.|.|:.|
  Fly   261 HHNTTFTCQAQNTADR----TYRSAKLLLEVKYAPKVIVSVVGG-ALAGGKIPEGAEVILSCQAD 320

Human   295 GSPSP-EYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYG---CRVEDYDAADDVQLSKTLE 355
            .:|.. .|..| :.||.       :.|:.|.:.:....|..|.   .:.|..:|....:.||.|:
  Fly   321 ANPHELSYRWF-INDEL-------MTGDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLD 377

Human   356 LRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTP--LGDGPMLSLSSITFDS 418
            :.   ..|:.......:...|.::..:.|.|.|.|.|.:.|..:::.  :|....|.| .::.::
  Fly   378 IS---FGPVFRQRPVSVEADLGATVSMRCDVAGNPEPEIEWISENSDQVVGVAAELKL-KVSSET 438

Human   419 NGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPK- 482
            .|.|.|:|.:...|.:.  ...||.|:.:|.:.:.:::     ....|..|.:.|.|...|..:
  Fly   439 AGRYFCKAVVNGFPEIG--AEATLYVKRAPIITSHKVQ-----FGGVGGRVKIDCLAFSIPKAEH 496

Human   483 LSWSQLGG----SPAEP---------IPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHV 534
            :.||..|.    |.|:|         :|  :| |.::|.::.:.|......:|...|.:|....|
  Fly   497 ILWSFEGKIINMSSADPDIYIFEEHHLP--EG-VRAALIIRDSKATHFGKYNCTVMNSYGGDSLV 558

Human   535 FHFGTV--SPQTSQAGVAVMAVAVSVGLLLLVVAVFYCVRRKGGPCCRQRREKGAPPPGEPGLSH 597
            .   |:  .|......:.||.....|.::|::|.:....|:      |:.|:|..|....|..|.
  Fly   559 I---TLLREPGNIPVLLVVMGSMFCVAIILMIVMIIIVYRK------RRSRKKPMPADVIPEASR 614

Human   598 SGSEQPEQTGLLMGGASGGARGGSGGFG 625
            .|.:..|....|...|.......:||.|
  Fly   615 GGDKLNELKSELRSKAYDVEYSEAGGDG 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BCAM	NP_005572.2	Ig	37..143	CDD:325142	26/106 (25%)
		C2-set_2	151..248	CDD:311910	23/97 (24%)
		IG_like	280..358	CDD:214653	20/81 (25%)
		Interaction with laminin alpha5	309..312		1/2 (50%)
		IGc2	377..427	CDD:197706	12/51 (24%)
		Ig_3	464..526	CDD:316449	17/75 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..628		13/47 (28%)
kirre	NP_001245505.1	Ig	87..183	CDD:299845	26/107 (24%)
		IG_like	88..182	CDD:214653	26/106 (25%)
		C2-set_2	189..279	CDD:285423	23/102 (23%)
		Ig_2	307..379	CDD:290606	20/79 (25%)
		I-set	382..462	CDD:254352	18/82 (22%)
		IGc2	396..446	CDD:197706	12/50 (24%)
		Ig	466..561	CDD:299845	21/105 (20%)
		IG_like	478..561	CDD:214653	20/88 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910