DRSC/TRiP Functional Genomics Resources

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Protein Alignment BCAM and syg-2

DIOPT Version :9

Sequence 1:NP_005572.2 Gene:BCAM / 4059 HGNCID:6722 Length:628 Species:Homo sapiens
Sequence 2:NP_001309674.1 Gene:syg-2 / 181561 WormBaseID:WBGene00007750 Length:1230 Species:Caenorhabditis elegans


Alignment Length:592 Identity:137/592 - (23%)
Similarity:229/592 - (38%) Gaps:151/592 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    16 LLLLAVLL----AAHPDAQAEVRLSVPPLVEVMRGKSVILDCTP---------------TGTHDH 61
            :|..|:||    :.|..:|  ..|..|..:..:.|:|:...|:.               ||:...
 Worm     1 MLSQAILLWLFGSIHISSQ--FFLESPSNLSTIAGESITFRCSAEKSPEPIVYSQWKSNTGSLLG 63

Human    62 YMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCV 126
            |..|..|....|   |.:..:....||                    .|.:....:.|:.:|.|.
 Worm    64 YHQEGILPGHQG---RFSYIKQNAEEL--------------------HLKITHVNLDDDGEYECQ 105

Human   127 VRAGAAGTAEATARLNVFAKPEATEVS---PNKGTLSVMEDSAQEIATCNSRNGNPAPKITWYRN 188
            :.....|...|.:.||:...|:....|   || ..::|.|::...| ||...|..|.|::.||.:
 Worm   106 MLHPEEGPIRAKSFLNIIVPPQLVYFSNYQPN-SIIAVKENTPLNI-TCVVPNVKPEPEVLWYMD 168

Human   189 GQRLEVPVEMNPEGYMTSRTVREAS-GLLSLTSTLYLRL----RKDDRDASFHCAAHYSLPEGRH 248
            |:             :.||.|::|| ..|:.|.|:|..|    .::|......|.|   ..:...
 Worm   169 GK-------------VMSRDVKQASTPHLNKTFTVYTSLVVQSDRNDHGKVITCEA---FQKETD 217

Human   249 GRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCR-GDGSPSPEYTLFRLQDEQEE 312
            .|:.:.|....|..|::.....:.:||.    :|.||.|.:.|. ..|:|.|:  :|...:    
 Worm   218 IRITTNTTLDVLFPPSDPTVEILRNPSA----LRSGDNVTIACSVTGGNPPPD--VFWYHE---- 272

Human   313 VLNVNLEGNLTLEGVTRGQS---------------GTYGCRVEDYDAADDVQLSKTLELRVAYLD 362
              |..|:.:.||:  ||.:.               ..|.||..:....:..:  |.::|.|.| .
 Worm   273 --NKRLQSHSTLD--TRSKEIKNIYSFIASQNDNMAEYECRANNSRTGNPKR--KAMKLEVNY-P 330

Human   363 P--LEL-SEGKV----------LSLPLNSSAVVNCSVHG--LPTPALRWTKDSTPLGDGPMLSLS 412
            |  :|| .|..:          .|||.|.::.:...::|  :|||    |:....:.:| ::|.|
 Worm   331 PASVELFGESNIRYGSSANIQCKSLPSNPASQITWIINGRSVPTP----TQREFVVENG-IVSSS 390

Human   413 SITFDSNGTYVCEA------SLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTL 471
            :::..||...| ||      .:.|.|..|..:...:.:...|  |...|....|..:.|||.|.:
 Worm   391 NVSVHSNELSV-EAHQINVECMATNPEGSSAKQHVIKIIAPP--KAPIITGLEDRKFFEGDIVNV 452

Human   472 ICSAR-GHPDPKLSWSQLGGSPAEPIPGRQ---------------GWVS-SSLTLKVTSALSRDG 519
            .|.|: |:|..:|||.:  ||....:.||:               |:.| |:|.|:|...::...
 Worm   453 TCEAQGGNPLAELSWYR--GSEKHLVKGRKKMKWSQVNGAHNEVAGFSSYSTLALRVDRTMNTQR 515

Human   520 ISCEASN 526
            :.|||:|
 Worm   516 LKCEATN 522

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BCAMNP_005572.2 Ig 37..143 CDD:325142 20/120 (17%)
C2-set_2 151..248 CDD:311910 27/104 (26%)
IG_like 280..358 CDD:214653 20/93 (22%)
Interaction with laminin alpha5 309..312 0/2 (0%)
IGc2 377..427 CDD:197706 14/57 (25%)
Ig_3 464..526 CDD:316449 24/78 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 579..628
syg-2NP_001309674.1 IG_like 25..105 CDD:214653 16/102 (16%)
Ig 33..122 CDD:299845 19/111 (17%)
Ig 147..228 CDD:299845 24/97 (25%)
IGc2 248..313 CDD:197706 17/74 (23%)
Ig 450..537 CDD:299845 22/75 (29%)
Ig 559..632 CDD:299845
I-set 657..738 CDD:254352
Ig 665..738 CDD:299845
IG_like 748..828 CDD:214653
IGc2 756..817 CDD:197706
Ig 845..922 CDD:299845
FN3 934..1023 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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