Protein Alignment tacc and TACC1

DIOPT Version :9

• Sequence 1: NP_001189169.1
• Gene: tacc / 40589
• FlyBaseID: FBgn0026620
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: NP_001339707.1
• Gene: TACC1 / 6867
• HGNCID: 11522
• Length: 821
• Species: Homo sapiens
• Alignment Length: 1063
• Identity: 220/1063 - (20%)
• Similarity: 371/1063 - (34%)
• Gaps: 342/1063 - (32%)

  Fly   304 PENNFVHYHPNQEQNRVELDQL--AKHSKPNSDAKESESLVESVLSEESGTQSFEPKLTLSALDS 366
            ||.:     |.:|.::.|...|  :..|:.|.:..|:|:.:.|...|     |.:|.|.|:...
Human    51 PEGD-----PEEEDSQAETKSLSFSSDSEGNFETPEAETPIRSPFKE-----SCDPSLGLAGPG- 104

  Fly   367 TKDLAKHQEEMQTNTKDIFQKEKHHPVSSAQVKDAQNPKE---PEKALNLKEASSELSTKSAKSL 428
                ||.||..:.:.:.:.:     .|.....|....|.|   |::|::         :.|.|:.
Human   105 ----AKSQESQEADEQLVAE-----VVEKCSSKTCSKPSENEVPQQAID---------SHSVKNF 151

  Fly   429 EYPNQEKQFSVAVESMERPCTAISLEQNASPAMEATEDRTVEELDQMDVDESMKVDDATVLNSCR 493
               .:|.:...:..|:.||   .|:|         |:|.|               |.:.||.:..
Human   152 ---REEPEHDFSKISIVRP---FSIE---------TKDST---------------DISAVLGTKA 186

  Fly   494 QEQINAHSPVSSKFFLKLCVQNDTDCQDNKMDQKTAGKESALKMTEIELPVESVPSASLSPP--T 556
                 ||..|::.....|........||..|.:.:.|       ..:|...|:...|..|.|  .
Human   187 -----AHGCVTAVSGKALPSSPPDALQDEAMTEGSMG-------VTLEASAEADLKAGNSCPELV 239

  Fly   557 PALQAKIIELSLSPPIPTHRPKTAEELEF----LALRELPLPDGVSTAGKVECKQLSHGLVPIVA 617
            |:.::|     |..|.|....|.|...||    .|:...|||            :.|:...|
Human   240 PSRRSK-----LRKPKPVPLRKKAIGGEFSDTNAAVEGTPLP------------KASYHFSP--- 284

  Fly   618 VLPTPLYLDLKGNTTTASLPEPTSPSFPIKEPAEKQSHFPRSPRAQLEQKDMPYLEEAVVERSSH 682
                            ..|.|.|||..       ..:.|.:||         |.|:|.....||
Human   285 ----------------EELDENTSPLL-------GDARFQKSP---------PDLKETPGTLSS- 316

  Fly   683 RKQSDFGVIAKSPIVFELTQPSPEKQHLNETLPMSEISPTSSNMTFDSGSITEDKSQKGTENIEP 747
             ..:|.||     .:.|.::.||.|                  :.||   .|||     |.|||.
Human   317 -DTNDSGV-----ELGEESRSSPLK------------------LEFD---FTED-----TGNIEA 349

  Fly   748 SSTLAVSLGSVDDKQRRTFSVVQPTKEEEEAKSRRTFCMENENPRRTFCMQQNASPAVEATEDTG 812
            ...|...||      |:..|.:.|.             ::.:...::..::|...|...
Human   350 RKALPRKLG------RKLGSTLTPK-------------IQKDGISKSAGLEQPTDPVAR------ 389

  Fly   813 ADEVMDVDISMRADEVAVMKSHQQTWKE-------RQAPISNSPPIPTHQRLNRPP----EAISP 866
                 |..:|..:.     |.....|:.       ..:.:.||||:.:....:..|    |::.|
Human   390 -----DGPLSQTSS-----KPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDP 444

  Fly   867 ------------VSPLGNGTVVLEEQTLSAKEQATLSASDEK---------DDVFLEHFGAISPV 910
                        .||.||....:.|....||.:...|....|         |....:....||.:
Human   445 FKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQI 509

  Fly   911 SDDMFKTSSASNNQAKFRVNADEETGGKGASAMIRKRSGTAGEQEEIFDAEFHDGVNNQNLILNS 975
            ||...:...|::.:..    |....|.|.|.|.::      ||.||  |.|:.:
Human   510 SDISNRDGHATDEEKL----ASTSCGQKSAGAEVK------GEPEE--DLEYFE----------- 551

  Fly   976 SDFDYLYTKGSNSVPIDRSSLLLKFDPLLGAPVPVNHPNQQEQALQNILGSNQHQNRLLSPTLEE 1040
                      .::||:.                .:||.....:|            .:...|.::
Human   552 ----------CSNVPVS----------------TINHAFSSSEA------------GIEKETCQK 578

  Fly  1041 HETSDGNQSFGVISSAKDTAKKWDFKPPVDRTKKHVKMSVDV-----IDNDCNKTFDNSNTNTED 1100
            .| .||:...|::.|:.:       |.||         ||..     :|..|
Human   579 ME-EDGSTVLGLLESSAE-------KAPV---------SVSCGGESPLDGIC------------- 613

  Fly  1101 KTHNYNDMDELEKKIKNEVTRSEDIEKKLKEGELREEALIKRITEKDKTNAKLNGVIEAYEKAIA 1165
                   :.|.:|.....:.|.|.|.|:::..|.:     |:..|..:...::..::..|||.||
Human   614 -------LSESDKTAVLTLIREEIITKEIEANEWK-----KKYEETRQEVLEMRKIVAEYEKTIA 666

  Fly  1166 ELISEKEQQAQLHERQLQEVQADRDANYHHLTSLETTFSDLHVKYEKSKEMTSQLKSNEESLLAE 1230
            ::|.::::.:...::..|::..:::.....|.|:|.:.|||..:||..|.:....|.|||:|...
Human   667 QMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKC 731

  Fly  1231 RKQMMDNLRLQEQRYDKMKNHAMQQLEIANKKLDTYSREHADETKKLKALLKKEEISRVSMTEQL 1295
            .:..:..::.:||||..:|.||.::|:.||:::.....:...|:..|.|.|:||::...|:...|
Human   732 AQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERAL 796

  Fly  1296 QQKSRENADLLKICEELIYGKGQ 1318
            |||::|..:|.|||:|||...|:
Human   797 QQKNQEIEELTKICDELIAKLGK 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tacc	NP_001189169.1	TACC	1103..1313	CDD:282818	57/209 (27%)
TACC1	NP_001339707.1	TACC	615..814	CDD:309929	57/203 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6571
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S6152
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002147
OrthoInspector	1	1.000	-	-		otm42037
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13924
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9199
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.950