Protein Alignment tacc and Tacc2

DIOPT Version :9

• Sequence 1: NP_001189169.1
• Gene: tacc / 40589
• FlyBaseID: FBgn0026620
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: XP_006508127.1
• Gene: Tacc2 / 57752
• MGIID: 1928899
• Length: 2928
• Species: Mus musculus
• Alignment Length: 1520
• Identity: 330/1520 - (21%)
• Similarity: 532/1520 - (35%)
• Gaps: 435/1520 - (28%)

  Fly    11 PKSIATTGISTNQPTTMEALEAASPAD-------------------ECSTPRDKGGVTLVSAHLD 56
            ||.:| .|:.|......:...||..|:                   |..|.|...||...|||..
Mouse  1631 PKMLA-GGVLTTPLDPSKMARAAEEAEGDVTPSRAETWACASGDLLETGTTRMLPGVAGNSAHPG 1694

  Fly    57 SLLESA--------SEELQRLEGK---------------------HCELFMESISNPLPAPEDST 92
            |..:|.        .|:...|:|.                     |.:   .|||:| |.|::|.
Mouse  1695 SFQDSGCSNRAQVMEEDAATLQGDSQVEDQQAKQQLGPQLPTPVGHGK---PSISSP-PEPDESK 1755

  Fly    93 DSREEIQKFLSEINFNLNQVSANEMEHLQAMSGELSPLAVKPSPKPTSMDQQ---------KAMA 148
            |.:             |:.|:..|:     :|...|     |.|.|.::...         .|.|
Mouse  1756 DEK-------------LHLVAPEEL-----LSDRKS-----PGPGPATLPSVPEACVPKGFPAEA 1797

  Fly   149 AALGHQTAVPGGLKPEDDLV----PKFGGLPEFDETQIPELAPLSTDMDTQLKSNHSDSDVFVEC 209
            ..||...::||    .||::    |...|.|           ||:.      .|:|.|:   |..
Mouse  1798 RDLGGVESIPG----TDDVIQPAAPVDPGHP-----------PLAD------SSHHGDA---VSS 1838

  Fly   210 LSLHSERYTGDRSELEAYSSALNDVLEQQLSMTSVSTLGAEFNDPLAVSQH--NNVSYEAMDVDD 272
            :|.|....:...|...|..:.|  ..|...|..|.:..|.|.. |.|..||  .| ...:.|.::
Mouse  1839 VSTHLTVQSASPSAARASPAPL--APEHTASAPSAAGPGVEVT-PTASPQHLAKN-EPRSSDSEE 1899

  Fly   273 LNETMEMLKDVLNAEDRHLMQTHILSVTQSKPENNFVHYHPNQEQNRVELDQLAKHSKPNSDAKE 337
            ..||.|              .|..:....:.|                         .|..:...
Mouse  1900 AFETPE--------------STTPVKAPPAPP-------------------------PPPPEVTP 1925

  Fly   338 SESLVESVLSEESGTQSFEPKLTLSALDSTKDLAKHQEEMQTNTKDIFQKEKHHPVSSAQVKDAQ 402
            ...:::....||.|..| ||.:.:      .|..:..|.::.:.    .:..|   ||:.|.|..
Mouse  1926 EPEVIDPPAPEEPGCIS-EPPVVV------PDGPRSSESVEGSP----FRPSH---SSSAVFDED 1976

  Fly   403 NPKEPEKALNLKEASSELSTKSAKSLEYPNQEKQFSVAVESMERPCTAISLEQNAS--------- 458
            .|.......||...|.|| ..:.:|||                 ||:|.|..|...
Mouse  1977 KPIASSGTYNLDFDSIEL-VDNFQSLE-----------------PCSADSKGQECKVSTRRKSTE 2023

  Fly   459 --PAMEATEDRTV----EELDQMDVDESMKVDDATVLNSCRQEQINAHS---------PVSSKFF 508
              |..::|..|::    .:.|......|.:....|. ::|.....:|.|         |.|.|
Mouse  2024 SVPPSKSTLSRSLSLQASDFDGASCPGSPEAGTLTT-DACGTGSNSASSTLKRTKKTRPPSLK-- 2085

  Fly   509 LKLCVQNDTDCQDNKMDQKTAGKESALKMTEIELPVESVPSA-------SLSPPTPALQAKIIEL 566
            .|...:..|:....|..|:..|:||.:...|...|.....||       :||..||      :|
Mouse  2086 KKQATKKPTETPPVKETQQEPGEESPVPSEEHLAPETKTESATPEGAGCTLSDDTP------LE- 2143

  Fly   567 SLSPPIPTHR-PKTAEELEFLALRELPLPDGVSTAGKVECKQLSHGLVPIVAVLPTPLYLDLKGN 630
              ||.:||.. |.|.|..|.::    ||   ||..|:|:..       |.|.....||
Mouse  2144 --SPAVPTATCPLTLESAEDVS----PL---VSGGGRVQNS-------PPVGRKSVPL------- 2185

  Fly   631 TTTASLPEPTSPSFPIKE--PAEKQSHFPRSPRAQLEQKDMPYLEEAVVERSSHRKQSDFGVIAK 693
            ||.:...|.|......:|  ||:     ..|.|.:.:..:.....|:..|.:...|:.....:||
Mouse  2186 TTASEAVEVTLSDSGGQEDLPAK-----GLSVRLEFDYSEDKGSWESQQENAPPTKKIGKKPVAK 2245

  Fly   694 SPIVFELTQPSPEKQHLNETLPMSEISPTS-SNMTFDSGSITEDKSQKGTENIEP-SSTLAVSLG 756
            .|:.....:.:|||  |:.|......|||. |:.....|:.|.|..:....|..| |||..:...
Mouse  2246 MPLRRPKMKKTPEK--LDNTPASPPRSPTEPSDTPIAKGTYTFDIDKWDDPNFNPFSSTSKMQES 2308

  Fly   757 SVDDKQRRTFSVVQPTKEEEEAKSRRTFCMENENPRRTFCMQQNASPAVEATEDTGADEVMDVDI 821
            ....:|...|   .|...||.....:.......:|.::....:..:...||..|...........
Mouse  2309 PKLSQQSYNF---DPDACEESLDPFKASSKTPSSPSKSPASFEIPASTTEADGDGLNKPAKKKKT 2370

  Fly   822 SMRADEVAVMKSHQQTWKERQAPISNSP---PIPTHQRLNRPPEAISPVSPLGNGTVVLEEQTLS 883
            .::.|...|.||      .:::|:|:.|   |.|.     ..|||.|.:|.:.:.|   :|:.|:
Mouse  2371 PLKTDTFRVKKS------PKRSPLSDPPSQDPTPA-----ATPEAPSAISTVVHAT---DEEKLA 2421

  Fly   884 AKEQ----ATLSASDEKDDVFLEHFGAISPVSDDMFKTSSASN--NQAKFRVNAD-EETGGKGAS 941
            ...|    .|:....:|.|.         |...|:      ||  |:.||...:: ::.||:...
Mouse  2422 VTSQKWTCMTVDLDADKQDF---------PQPSDL------SNFVNETKFNSPSEGKQLGGQPDP 2471

  Fly   942 AMI---------RKRSGTAGEQEEIFDAEFHDGVNNQNLILNSSDFDYLYTKGSNSVPID----- 992
            .:.         |.|.||.  |.|:   ::.          ||.:.:|:...|| |:|.|
Mouse  2472 HLALENTVPRGQRARKGTC--QPEL---DYR----------NSYEIEYMEKLGS-SLPQDDDTPK 2520

  Fly   993 RSSLLLKFDPLLGAPV---PVNHPN----------QQEQALQNILGSNQH---------QNRLL- 1034
            :.:|.|.||....:||   ||...:          :..:||.|.....||         |..||
Mouse  2521 KQALYLMFDTPQESPVKSPPVRMSDSPTPCSGSSFEDTEALVNAATKLQHPVARGLPSSQEPLLQ 2585

  Fly  1035 ---SPTLEE---------HETSDGNQSFGVISSA---------------------KDTAKKWDFK 1066
               .|:.:|         .|..:.....|..:||                     .|.|:|   .
Mouse  2586 VPEKPSQKELEAMALGTPAEAIEITAPEGAFASADTLLSRLAHPASLCGALGYLEPDLAEK---N 2647

  Fly  1067 PPVDRTKKHVKMSVDVIDNDCNK--------TFDNSNTNTE---------DKTHNYNDM--DELE 1112
            |||...|...::...|:..:..|        :....:|..|         .||..|:.:  .|:|
Mouse  2648 PPVFAQKLQEELEFAVMRIEALKLARQIALASRSRQDTKREAAHPPDVSISKTALYSRIGSTEVE 2712

  Fly  1113 K-----------KIKNEVTRSEDIEKKLKEGELREEALIKRITEKDKTNAKLNGVIEAYEKAIAE 1166
            |           ....:|.|:|.|.|:.:..|.|:     :..|..:...::..::..|||.||:
Mouse  2713 KPPGLLFQQPDLDSALQVARAEVIAKEREVSEWRD-----KYEESRREVVEMRKIVAEYEKTIAQ 2772

  Fly  1167 LI---SEKEQQAQLHERQLQEVQADRDANYHHLTSLETTFSDLHVKYEKSKEMTSQLKSNEESLL 1228
            :|   .:::::..:..:.:|::..:::.....|.|:|.:.:||..:|||.||:....:.|||.|.
Mouse  2773 MIGKPEDEQREKSISHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLK 2837

  Fly  1229 AERKQMMDNLRLQEQRYDKMKNHAMQQLEIANKKLDTYSREHADETKKLKALLKKEEISRVSMTE 1293
            ...::.:..::.:||||..:|.||.::|:.||.::.....:...|....:|.|:||::...::..
Mouse  2838 KCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAYQASLRKEQLRVDALER 2902

  Fly  1294 QLQQKSRENADLLKICEELIYGKGQ 1318
            .|:||::|..:|.|||:|||...|:
Mouse  2903 TLEQKNKEIEELTKICDELIAKMGK 2927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tacc	NP_001189169.1	TACC	1103..1313	CDD:282818	57/225 (25%)
Tacc2	XP_006508127.1	PHA03307	1748..>2120	CDD:223039	99/497 (20%)
		PRK13335	2053..>2164	CDD:139494	31/126 (25%)
		TACC	2719..2922	CDD:368238	53/207 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6909
eggNOG	1	0.900	-	-		E1_2C9BM
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002147
OrthoInspector	1	1.000	-	-		otm44090
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13924
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5538
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.900