DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tacc and tacc2

DIOPT Version :9

Sequence 1:	NP_001189169.1	Gene:	tacc / 40589	FlyBaseID:	FBgn0026620	Length:	1322	Species:	Drosophila melanogaster
Sequence 2:	XP_021336525.1	Gene:	tacc2 / 569976	ZFINID:	ZDB-GENE-030131-9748	Length:	3736	Species:	Danio rerio

Alignment Length:	2007	Identity:	373/2007 - (18%)
Similarity:	598/2007 - (29%)	Gaps:	813/2007 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IKRPKSIATTGISTNQPTTMEALEAASPADECSTPRDKGGVTLVSAHLDSLLESASEELQRLEGK 72
            |..|:::.:.|.|    ..::..|..:.||..::.:.:......||...|..:|.||..:.:||.
Zfish  1846 ISAPEAVLSLGKS----CALKNAETNNHADADASEKQEKVTVYCSAEAKSSPDSTSESAELVEGH 1906

  Fly    73 HCELFMESISNPLPAPEDSTDSREEI---------QKFLSEI------NFNLNQVSANEMEHLQA 122
            |.:..::||   .|..||.:...:|:         :..|||.      |..:|.||.:|....:.
Zfish  1907 HRDFNVDSI---CPQNEDLSIPTKELRGEKSHVCGESTLSETQTQPAPNLPVNAVSGSETSEFKR 1968

  Fly   123 MSGELSPLAVKPSPKPTSMDQQKAMAAALGHQTAVPGGLKPEDDLVPKFGGLPEFDETQIPELAP 187
            :   :..|.||......|.:.....|.....|.:           ..::|.:  :::|
Zfish  1969 V---IKALEVKQFVISASQESVNKHADCSNSQVS-----------ADEYGNV--WNKT------- 2010

  Fly   188 LSTDMDTQLKSNHSDSDVFVECLSLH-------SERY-----TGDRSELEAYSSALNDVLEQQLS 240
            |:|....:|..:|| |.:......||       .|.|     .||....|....::::|.:...:
Zfish  2011 LATKKGAELPVSHS-SGLSASPSVLHYEEGIKTDEHYLDFVTPGDTGNTEIRPDSVSEVAQMSAA 2074

  Fly   241 MTSVSTLGAEFNDPLAVSQHNNVSYEAMDVDDLNETMEMLKDVLNAEDRHLMQTHILSVTQS--- 302
                        :|..:.|...:.::..|....::|.......|   :..:.:...:||.|:
Zfish  2075 ------------EPSQLQQEKELIFQPSDAQCSSDTARFSATAL---EESIKEEKEISVDQASKD 2124

  Fly   303 --KPENNFVHYHPNQEQNRVELDQLAKHSKPNSDAKESESLVESVLSEE--SGTQSFEPKLTLSA 363
              ||  |..:..|..|.....::||.||                 |||:  .|||:.|.:.||.
Zfish  2125 ALKP--NAPNSTPESETAAWRMEQLNKH-----------------LSEQFPDGTQNTEKQHTLC- 2169

  Fly   364 LDSTKDLAKHQE-------EMQTNT---KDIFQKEKHHPVSSAQVKDAQNPKEPEKA-LNL-KEA 416
              |.|.|.:.|.       |.|..|   :|.|..::..|....:....|..:..||. :.| |..
Zfish  2170 --SEKQLTQLQHAVTCSGTENQIGTMKAEDTFSNDRQEPQGIQEETSKQINETAEKCHMELSKGT 2232

  Fly   417 SSELSTKSAK-SLEYPNQEKQFSVAVESMERPCTAISLEQNASPAMEATEDRTVEELDQM----- 475
            ...||....| |:...||.|     ||:.....:..|:..|....:|...|..:.|:||:
Zfish  2233 GPNLSENVGKESMSKENQSK-----VEAHSLSASEESIVCNVDQPIEIATDGVLIEMDQVVSLLC 2292

  Fly   476 ------------------------DVDESMKVDDATVLNSCRQEQINAHSPVSSKFFLK------ 510
                                    .:::.....|.....|....:|...||.::|...|
Zfish  2293 PETASCVVTYPQDCLQPPFTVNQQSIEQHKSSSDTLKSGSEEHPEIANSSPANAKAIQKDDSEAS 2357

  Fly   511 ----------------------LCVQNDTDCQ-------------DNKM---------------- 524
                                  :.|::.||.|             .||:
Zfish  2358 EEKVNMVSQAADDGLLGSGPGAVQVKDSTDTQTDSTDSANFVPERSNKVNSSEGSDWLRVLKEAA 2422

  Fly   525 ----------DQKTAGK------ES-ALKMTEIEL------------------------------ 542
                      |:.|.|.      || .....|:|.
Zfish  2423 SMSQVIPEHKDETTCGSTDNRPFESFGSPQAELEFRTPTGEFLPPAPEESFPPGPEETFPPAPED 2487

  Fly   543 -----PVESVPSASLS----------PPTPALQAKIIELSLSPPIP-------THRPKTAEE--- 582
                 ||||.|.||..          ||.|......:...:.||.|       |.:|:.|.:
Zfish  2488 SFPPGPVESFPLASEDTFPPAPEDNFPPPPEESFPPVPEEIFPPAPEESFPLVTEQPEEASDCRS 2552

  Fly   583 --LEFLALRELPLPDGVSTAGKVECKQLSHGLVPIVAVLPTPLYLDLKGNTTTASLPEPTSPSFP 645
              ||.....| |:|...|...:       |...|   .||..|..|      |...|.| .|:.|
Zfish  2553 PLLEAAEWSE-PVPSPSSLPPQ-------HSFAP---ALPAHLLQD------TLEFPTP-PPTPP 2599

  Fly   646 IKEPAEKQS---------------HFPRSPRAQLEQKDMPYLEEAVVERSSHRKQSDFGVIAKSP 695
            .:.|||.|:               .||..|..|..|...|....:..:.:....:|...|.:.||
Zfish  2600 DRAPAEPQTFPPAPDPSDLPQISPDFPLPPPVQQLQHSEPSARSSDSDGAFETPESTTPVKSVSP 2664

  Fly   696 IVFELTQP-------SPEKQHLNETLPMSE-------ISPTSSNMTFDSGSITEDK--SQKGTEN 744
            .|.....|       ||:....:..:|.||       .||:.|    ||.:..|||  :..||.|
Zfish  2665 SVPPTEHPYTSSETLSPKHTASSSDVPASEGEDPSLHRSPSRS----DSTAFDEDKPIAASGTYN 2725

  Fly   745 IE--------PSS-----------TLAVSLGS------------VDDK----QRRTFSVVQPT-- 772
            :|        |.|           |.:.||.|            :.||    :..:|::...:
Zfish  2726 LEYLISNDPFPESNFGSGSSRAPLTRSQSLQSGELESPGNKSPGISDKPIHPRTESFNIGTESAP 2790

  Fly   773 -------KEEEEAKSRRTFCMENENPRR--------------------------------TFCMQ 798
                   |....:..::....:|.||.|                                :....
Zfish  2791 GTLRRVKKPRPGSLKKKPLSRQNSNPERSSPKTVSSSSTPEQKKRGKPRPESPLQTQDKPSSSPS 2855

  Fly   799 QNASPAVEATEDTG----------ADEVMDVDISMRA----------------DEVAVMKSHQQT 837
            .:.|||.....:.|          |:|:....||.:.                :|..::.|....
Zfish  2856 PSPSPAGTLRRNRGKSQVESSPPLAEEITTTSISAQPLLELPDPVPEASTVPDEESPILPSASYK 2920

  Fly   838 WK----ERQAP-------ISNSP-------------------------------------PIPTH 854
            |.    |...|       |:|||                                     |||..
Zfish  2921 WDPDNFENINPFSTGGSKIANSPVLGRKADFTSVQDTPAALEQPRAPSPAKAQPLNVEEQPIPNR 2985

  Fly   855 Q-----------------------RLNRPPEAISPVSPLGNGTVVLEEQTLSAKEQATLSA-SDE 895
            |                       .|.:.|.|..|:.....|........:...:.|.|.| |::
Zfish  2986 QPVRLEFDYSEDSGEASRSTPPPKNLGKKPGAKMPIRKPKLGIKKAPPPQMEQIDNAPLPALSND 3050

  Fly   896 KDDVFL-----------------------------------------EHF-GAISPVSDDMFKTS 918
            .||:.:                                         :.| |:|||     ||:|
Zfish  3051 NDDIPIPKASYNFDPSKWEDPNFNPFSSNTGIPNSPGLSKGSYSFESDSFDGSISP-----FKSS 3110

  Fly   919 S--------------ASN---------------NQAK-------------FRVN----------- 930
            |              .||               ||.|             |||.
Zfish  3111 SKIGNSPPKGASFDQTSNDNENDNDHIVELEDHNQNKPAKTKKKPLKSNTFRVKKSPKRTQIPDP 3175

  Fly   931 ------------------------------------------ADEETGGKGASAMIRKRSG---- 949
                                                      .|||   |.||:..:|.:.
Zfish  3176 PAQVSQDCCPVCSPLSPTTSHTHHHLQEHSPDADPDPSQDHATDEE---KLASSTNQKWTRHDVE 3237

  Fly   950 ---TAGEQEEIFDAEFHDGVNNQNLILNSSD-----FDYLYTKGSNSVPID--RSSLLLKFD--- 1001
               |:|.|:.....:|...||..:  .:.||     .:|:...||::.|:.  :.||.||.|
Zfish  3238 VELTSGPQDFPQPTDFTAFVNENS--FSQSDVTDYEIEYMEKIGSSAPPLSGKKPSLYLKLDSVT 3300

  Fly  1002 ----------------PLLGA-----------------------PVPVNHPNQQEQALQNILGSN 1027
                            |..|:                       |:..:...:::...|:...||
Zfish  3301 ESTKSTSNMNDSEPNSPCTGSFEEMEAQISQGKSPVLPPRGTREPMTSDKSRKRDSQSQSRTQSN 3365

  Fly  1028 QHQ-----------------NRL---------LSPTLEEHETSDGNQSFG---VISS----AKDT 1059
            :..                 :||         |.|.|.|...:...|...   |:::    |...
Zfish  3366 ERDGASPIQGPMDPSDLPLLDRLSDSPAPLSYLEPDLAETNPTAFAQKLQEELVLAALRIEALQV 3430

  Fly  1060 AKKWDFKP------PVDRTKK-----------HV-KMSVDVIDND---CNKT------------- 1090
            ||.....|      |..|.||           |: |.:|.....|   |.:|
Zfish  3431 AKNISQSPTLSTVSPQSRLKKPSPRLWNINGSHMAKTAVKSTQTDRKLCRRTSRIPQTEIASPGD 3495

  Fly  1091 --------FDNSNTNTEDKTHNYNDMDELEKKIKNE--VTRSEDIEKKLKEGELREEALIKRITE 1145
                    :..:.....:..|...|||......:.|  |...|.:|.|.|..|.|.|.
Zfish  3496 SSVSKGSLYSRTGYIEGESPHLPRDMDHSLGIAREEIVVKEKEAMEWKRKYEESRREV------- 3553

  Fly  1146 KDKTNAKLNGVIEAYEKAIAELISE--------------KEQQAQLHERQLQEVQADRDANYHHL 1196
                 .::..::..|||.|||:|.:              ::::..:....:|::..::|.....|
Zfish  3554 -----EEMRRIVMEYEKTIAEMIDKSFVPPDPNTGMPEGEQREKSVSHHTIQQLILEKDQALADL 3613

  Fly  1197 TSLETTFSDLHVKYEKSKEMTSQLKSNEESLLAERKQMMDNLRLQEQRYDKMKNHAMQQLEIANK 1261
            .|:|.:.:||..:|||.|::....:.||:.|....::.:..:|.:||||..:|.||.::|:.||.
Zfish  3614 NSVEKSLADLFRRYEKMKDVLEGFRKNEDVLKKCAQEYLSRVRKEEQRYQALKIHAEEKLDKANS 3678

  Fly  1262 KLDTYSREHADETKKLKALLKKEEISRVSMTEQLQQKSRENADLLKICEELIYGKGQ 1318
            ::.....:...|....:|.|:||::...|:...|:||::|..:|.|||:|||...|:
Zfish  3679 EIAQVRAKAKQEQAAHQASLRKEQMKVDSLERTLEQKNKEIEELTKICDELIAKMGK 3735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tacc	NP_001189169.1	TACC	1103..1313	CDD:282818	60/225 (27%)
tacc2	XP_021336525.1	Neuromodulin_N	<1518..1754	CDD:331332
		Herpes_ICP4_C	2420..>2843	CDD:332854	87/444 (20%)
		Atrophin-1	<2610..3136	CDD:331285	86/534 (16%)
		TACC	3516..3730	CDD:309929	60/225 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6722
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002147
OrthoInspector	1	1.000	-	-		otm25358
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13924
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.010