DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tacc and tacc3

DIOPT Version :9

Sequence 1:	NP_001189169.1	Gene:	tacc / 40589	FlyBaseID:	FBgn0026620	Length:	1322	Species:	Drosophila melanogaster
Sequence 2:	NP_997746.1	Gene:	tacc3 / 321283	ZFINID:	ZDB-GENE-050522-327	Length:	942	Species:	Danio rerio

Alignment Length:	1088	Identity:	236/1088 - (21%)
Similarity:	394/1088 - (36%)	Gaps:	261/1088 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 NSDA-KESESLVES-----------VLSEESGTQSFEPKLTLSALDSTKDLAKHQEEMQTNTKDI 384
            :||| ||::..|..           :|.:.:|..|.   |..|..|:....|...      .|..
Zfish     2 SSDALKENQGAVRMNSNSEFACDIFMLDQPTGRPSI---LRQSQADNINRTAPRA------AKVC 57

  Fly   385 FQKEKHHPVSSAQVKDAQNPKEPEKALNLKEASSELSTKSAKSLEYPNQEKQFSVAVESMERP-- 447
            ||..:..||:    |...:|....:.::..:..:.|.|.:..|       .|.|:...:...|
Zfish    58 FQTPRRDPVT----KKIMSPSRTSRPISQDDHKNALETLTGLS-------DQSSLMNNTHTTPID 111

  Fly   448 --CTAISLEQNASPAMEATEDRTVEELDQMDVDESMKVDDATVLNSCRQEQINAHSPVSSKFFLK 510
              |.:::|..:..|    .:.|.....|         :|:...:|..:.....|:||..|..|.:
Zfish   112 IECNSVALPDDDMP----VQSRGAYSFD---------LDNIDAINPFQGSNKMANSPPKSSAFTE 163

  Fly   511 LC----VQNDTDCQDNKMDQKTAGKESALKMTEIELPVESVP------SASLS------PPTPAL 559
            ..    |:::|........|.....|:.:..:..|..|.||.      ||::|      .|..|.
Zfish   164 AATSELVESNTTIAPVSAPQVEVETEAEVTDSAFEEAVPSVENSLAECSANISSTEGNVAPVLAP 228

  Fly   560 QAKIIELSLS------PPIPTHRPKTAEELEFLALRE----LPLPDGVSTAGKVECKQLSHGLVP 614
            ||::.|::.|      |.:|:.....||....|:..|    |...:..::..:.|..:::.   |
Zfish   229 QAEVPEVTESALDETLPFVPSVENSLAECSANLSSAEGTVILKTENIENSTNETEETEITD---P 290

  Fly   615 IVAVLPTPLYLDLKGNTTTASLPEPTSPSFPIK-------EPAEK-QSHFPRSPRAQLEQK-DMP 670
            :......|::   :|......||.|::.|:.:.       .|.:. .|..|.||..:.... |.|
Zfish   291 VAEPQQIPVF---EGQPEAQDLPLPSAGSYKLDFDNLEMLNPFQTGGSKIPNSPPTKTSTVFDPP 352

  Fly   671 YLEEAVVERSSHRKQSDFGVIAKSPIVFELTQPS--PEKQHLNETLPMSEISPTSSNM----TFD 729
            .|        ||..:.:..|....|   ..:.||  |::.........|..:|..|.|    .||
Zfish   353 LL--------SHEPEQELSVQTDIP---TSSDPSITPQENSTATESSSSTTAPKESQMLLEFNFD 406

  Fly   730 SGSITEDK------SQKGTENIEP----SSTLAVSLGSVDDKQRRTFSVVQPTKEEE-------E 777
            .|:..:.|      ..|.|...:|    :..|.......:.||      :.||..||       .
Zfish   407 DGAEVKRKPPPKRLGVKRTVGAKPVPKKTDALVTEKKDAEPKQ------MSPTSPEETQPVDIPS 465

  Fly   778 AKSRRTFCME-----NENPRRTFCMQQNASPAVEATEDTGADEVMDVDISMRADEVAVMKSHQQT 837
            ||...||..|     |.||..|..|..|:.|....|                          ...
Zfish   466 AKGSYTFDFEQFDNPNFNPFGTKAMMGNSPPRGVQT--------------------------SPV 504

  Fly   838 WKERQAPISNSPPIPTH--QRLNRPPEAISPVSPLGNGTVVLEEQTLSAKEQATLSASDEKDDVF 900
            .|:.|:|:.....:|..  |...|.|:.:|.     :...::|......||    .|.|.:..:.
Zfish   505 LKKAQSPVKQLETLPAQDDQPEQRSPQVVSE-----SKENMVEANLPETKE----LAEDVESSMA 560

  Fly   901 LEHF----GAISPVSDDMFKTSSASNNQAKFRVNADEETGGKGASAMIRKRSGTAGEQEEIFDAE 961
            :.|.    ....|..|.|....|.::.|        .:|...|.:|        :.|.|.:..|.
Zfish   561 VPHTDKPQNPAVPEPDFMAVPESIADIQ--------NQTCDLGVAA--------SNEDEFVPGAL 609

  Fly   962 FHDGVNNQNLILNSSDF----DYLYTKGSNSV---PIDRSSLLLKFDPLLGAPVPVNHPNQQEQA 1019
            |..|          .||    |||...||::.   .:.:.||.|||||||......|...
Zfish   610 FMPG----------GDFDGQIDYLEQFGSSNFKESALRKQSLYLKFDPLLKESPKKNGGE----- 659

  Fly  1020 LQNILGSN---QHQNRLLSPTLEEHETSDGNQSFGVISSAKDTAKKWDFKPPVDRTKKHVKMSVD 1081
                 |||   ......|:..:.|...|:..|     .|..|:.|..|..||         ::|:
Zfish   660 -----GSNFGFCMPRPSLAIRMMEAAKSEVKQ-----KSQCDSVKLLDDLPP---------LAVE 705

  Fly  1082 VIDNDCNKTFD------NSNTNTEDK-----THNYNDMDELEKKIKNEVTRSEDIEKKLKEGELR 1135
            .:..| ....|      .....|||.     .::..|||..             ::|..::.|.|
Zfish   706 TVVPD-PTVLDLLVPALKPPVRTEDSIIEVLKYSQKDMDAA-------------LQKADRQSEER 756

  Fly  1136 EEALIKRITEKDKTNAKLNGVIEAYEKAIAELISEKEQQAQLHERQLQEVQADRDANYHHLTSLE 1200
            ::.|..:|.:....|.::..::..:|..|.::..|.:|:..|.:.:::.|..::|.....|..||
Zfish   757 QQELKSQIEKLQLENQQMLFIMSEFETTITQITDEHKQKEALAKMEMERVLEEKDQLAKDLNELE 821

  Fly  1201 TTFSDLHVKYEKSKEMTSQLKSNEESLLAERKQMMDNLRLQEQRYDKMKNHAMQQLEIANKKLDT 1265
            .:||.:..:.::.||:....|.|||:|....|..||.|:.:|:||..:|.||.::||.|||.:..
Zfish   822 RSFSSVVKRLDRCKEVIEGFKKNEETLKQYAKNCMDRLQKEEKRYQALKAHAEEKLEQANKAIAE 886

  Fly  1266 YSREHADETKKLKALLKKEEISRVSMTEQLQQKSRENADLLKICEELI 1313
            ...:...|...|:..||:|::...|:.:.|:||::|..|:.::|:||:
Zfish   887 VRTKQGAEVAALQVQLKREQLKVQSLEKDLEQKAKEVKDVTELCDELL 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tacc	NP_001189169.1	TACC	1103..1313	CDD:282818	56/209 (27%)
tacc3	NP_997746.1	SDP repeat 1	316..347		6/30 (20%)
		SDP repeat 2	469..502		11/58 (19%)
		TACC	737..934	CDD:282818	56/209 (27%)
		vATP-synt_E	742..>900	CDD:304907	44/170 (26%)
		TACC domain	746..942		54/189 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6722
eggNOG	1	0.900	-	-		E1_2C9BM
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002147
OrthoInspector	1	1.000	-	-		otm25358
orthoMCL	1	0.900	-	-		OOG6_106926
Panther	1	1.100	-	-	LDO	PTHR13924
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.770