DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tacc and Tacc1

DIOPT Version :9

Sequence 1:	NP_001189169.1	Gene:	tacc / 40589	FlyBaseID:	FBgn0026620	Length:	1322	Species:	Drosophila melanogaster
Sequence 2:	XP_006509206.1	Gene:	Tacc1 / 320165	MGIID:	2443510	Length:	788	Species:	Mus musculus

Alignment Length:	992	Identity:	194/992 - (19%)
Similarity:	350/992 - (35%)	Gaps:	297/992 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   394 SSAQVKDAQNPK-EPEKALNLKEASSELSTKSAK-------SLEYPNQEKQFSVAVESMERPCTA 450
            |.|...:|..|: :||     :|..|:..|||..       :.|.|..|....   ..::..|
Mouse    25 SGAGEDEAGGPEGDPE-----EEEDSQAETKSLSFSSDSEGNFETPEAETPIR---SPLKESC-- 79

  Fly   451 ISLEQNASPAMEATEDRTVEELDQMDVDESMKVDDATVLNSCRQEQINAHSPVSSKFFLKLCVQN 515
                 ::||.:...|.:..|   ..:.||.:.   |.|:..|        ||
Mouse    80 -----DSSPGLAEPEAKPQE---SREADEQLV---AEVIEKC--------SP------------- 112

  Fly   516 DTDCQDNKMDQKTAGKESALKMTEIELPVESVPSASLSPPTPALQAKIIELSLSPPIPTHRPKTA 580
                            ::..:.:|.|.|..:|.|..:.......:..:.::|:..|.........
Mouse   113 ----------------DTCSRSSENEAPQATVDSHPVKDVRGKAEHDVSKISVVRPFSIETRNCT 161

  Fly   581 EELEFLALRELPLPDGVSTAGKVECKQLSHGLVPIVAVLPTPLYLDLKGNTTTASLPEP------ 639
            ::           |..:.||.       :||.||::..:..|      ..|..|:..||
Mouse   162 DD-----------PAALGTAA-------AHGCVPVLPGMALP------STTPEATQDEPVMDRGM 202

  Fly   640 --TSPSF---------PIKEPAEKQSHFPRSPRAQLEQKDMPYLEEAVVERSSHRKQSDFGVIAK 693
              |..:|         |..||...:|.. |.|:....:|.|....|.::|.|...|       |.
Mouse   203 GVTLEAFTEASLKTGGPCPEPVASRSKL-RKPKPVSLRKKMAPEPEMLMEGSPLPK-------AS 259

  Fly   694 SPIVFELTQPSPEKQHLNET-----------LPMSEISPTSSNMTFDSG------------SITE 735
            ||.:     |....|:.|.:           |.:.|.:...||.|.|||            .:.:
Mouse   260 SPWL-----PDGLDQNANPSVLRGSGAQRSPLNLKETAGVLSNDTSDSGVELQGGSRDPPLQLED 319

  Fly   736 DKSQKGTENIEPSSTLAVSLGSVDDKQRRTFSVVQPTKEEEEAKSRRTFCMENENPRRTFCMQQN 800
            |.::.| ||::..|.|....|      |:..:.:.|:             :..:...:...::|.
Mouse   320 DFTEDG-ENVKIRSALPKQSG------RKPSNKLAPS-------------IRKDGVSKPVGVEQP 364

  Fly   801 ASPAVEATEDTGADEVMDVDISMRADEVAVMKSHQQTWKERQAPISNSPPIPTHQRLNRPPEAIS 865
            :.|.|:       |.::| .:|.:.|                 |...|.|
Mouse   365 SDPTVQ-------DALLD-QMSPKLD-----------------PSKRSHP--------------- 389

  Fly   866 PVSPLGNGTVVLEEQTLSAK-----EQATLSASDEKDDVFLEHFGAISPVSDDMFKTSS----AS 921
            |.:..|:|.::.....||:|     :...::..|..|           |.......|||    |:
Mouse   390 PANFFGSGPILQNSPPLSSKCSHHFDPNNINTDDSGD-----------PCKPTPALTSSGFCPAT 443

  Fly   922 NNQAKFRVNADEETGGKGASAMIRKRSGTAGEQEEIFDAEFHDGVNNQNLILNSSDFDYLYTKGS 986
            .|    .||...::..|..|.:|     |..||.: |......|...:.......|.|
Mouse   444 GN----HVNEILDSPKKAKSRLI-----TTTEQVK-FLCFLLSGCKVKKYEAQPLDLD------- 491

  Fly   987 NSVPIDRSSLLLKFDPLLGAPVPVNHPNQQEQALQNILGSNQHQNRLLSPTLEEHETSDGNQSFG 1051
             :...|..:::.|...:         ||:.        |....:.:|.|.:    ..:..:...|
Mouse   492 -ACSQDEGAVISKISEI---------PNRD--------GHATDEEKLASTS----SCAQKSAGAG 534

  Fly  1052 VISSAKDTAKKWDFKP-----PVDRTKKHVKMSV-----DVIDNDCNKTFDNSNTNTEDKTHNYN 1106
            |....|:|.:|.:.:.     .::.:.:...:||     ..:|..|
Mouse   535 VKGIEKETCQKMEKEELAVHGLLESSSEKAPVSVACGGESPLDGIC------------------- 580

  Fly  1107 DMDELEKKIKNEVTRSEDIEKKLKEGELREEALIKRITEKDKTNAKLNGVIEAYEKAIAELISEK 1171
             :.|.:|.....:.|.|.|.|:::..|.:     |:..|..:...::..::..|||.||::|.::
Mouse   581 -LSEADKTAVLTLIREEIITKEIEANEWK-----KKYEETREEVLEMRKIVAEYEKTIAQMIEDE 639

  Fly  1172 EQQAQLHERQLQEVQADRDANYHHLTSLETTFSDLHVKYEKSKEMTSQLKSNEESLLAERKQMMD 1236
            ::.:...::..|::..:::.....|.|:|.:.|||..:||..|.:....|.|||:|....:..:.
Mouse   640 QRTSMSSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLA 704

  Fly  1237 NLRLQEQRYDKMKNHAMQQLEIANKKLDTYSREHADETKKLKALLKKEEISRVSMTEQLQQKSRE 1301
            .::.:||||..:|.||.::|:.||:::.....:...|:..|.|.|:||::...|:...||||::|
Mouse   705 RVKQEEQRYQALKVHAEEKLDRANEEIAQVRSKAKAESAALHAGLRKEQMKVESLERALQQKNQE 769

  Fly  1302 NADLLKICEELIYGKGQ 1318
            ..:|.|||:|||...|:
Mouse   770 IEELTKICDELIAKLGK 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tacc	NP_001189169.1	TACC	1103..1313	CDD:282818	57/209 (27%)
Tacc1	XP_006509206.1	PPP1R26_N	<229..>392	CDD:374066	42/235 (18%)
Tacc1	XP_006509206.1	TACC	582..781	CDD:368238	57/203 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6909
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002147
OrthoInspector	1	1.000	-	-		otm44090
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13924
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9199
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	9.000