DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tacc and Tacc3

DIOPT Version :9

Sequence 1:	NP_001189169.1	Gene:	tacc / 40589	FlyBaseID:	FBgn0026620	Length:	1322	Species:	Drosophila melanogaster
Sequence 2:	XP_011239017.1	Gene:	Tacc3 / 21335	MGIID:	1341163	Length:	646	Species:	Mus musculus

Alignment Length:	783	Identity:	178/783 - (22%)
Similarity:	299/783 - (38%)	Gaps:	203/783 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   573 PTHRPKTAEELEFLALRELPLPDGVSTAGKVECKQLSHGLVPIVAVLPTPLYL-DLKGNTTTASL 636
            |.|.||         |..:..|....:.||.:.:         :...|.|..| :||.|....|.
Mouse    19 PQHPPK---------LCGVAAPICNPSTGKADWR---------IPGAPWPDCLAELKENVPPQSQ 65

  Fly   637 PEPTSPSFPIKEPAEKQSHFPRSPRAQLEQKDMPY-LEEAVVERSSHRKQSDFGVIAKSPIVFEL 700
            .:.|:.:|. ..|.:.|:|...||. ...:::.|: |:...........|.....:..:|:|...
Mouse    66 AKATNVTFQ-TPPRDPQTHRILSPN-MTNKREAPFGLQNDHCVFLQKENQRPLAPVDDAPVVQMA 128

  Fly   701 TQPSPEKQHLNETLPMSEISPTSSNMTFDSGSITE------DKSQKGTENIEPSSTLAVSLGSVD 759
            .:....:..|.|.: ::..|.::|....||..:|.      :.|.:|.|.:..|..:...:.
Mouse   129 AEILRAEGELQEGI-LTSSSLSASTSLLDSELVTPPIEPVLEPSHQGLEPVLESELVTPPVE--- 189

  Fly   760 DKQRRTFSVVQPTKEEEEAKSRRTFCMENENPRRTFCMQQNASPAVEATEDTGADEVMDVDISMR 824
                   .|::|:.:|.|.      .:|:|      .:.....|.:|.:.. |.:.|:|.::...
Mouse   190 -------PVLEPSHQELEP------VLESE------LVTPPIEPVLEPSHQ-GLEPVLDSELVTP 234

  Fly   825 ADEVAVMKSHQQTWKERQAPISNS----PPI-----PTHQRLN--------RPPEAISPV-SPLG 871
            ..|..:..|||..     .|:..|    |||     |:||.|.        .||  |.|| .|..
Mouse   235 PIEPVLEPSHQGL-----EPVLESELVTPPIEPVLEPSHQGLEPVLDSELVTPP--IEPVLEPSH 292

  Fly   872 NG-TVVLEEQTLSAKEQATLSASDEKDDVFLEHFGAISPVSD---DMFKTSSASNNQAKFRVNAD 932
            .| ..||:.:.::...:..|..|         |.| :.||.|   :.|:..|
Mouse   293 QGLEPVLDSELVTPPIEPLLEPS---------HQG-LEPVVDLKEESFRDPS------------- 334

  Fly   933 EETGGKGASAMIRKRSGTAGEQEEIFDAEFHDGVNNQNLILNSSDFDYLYTKGSNSVPIDRSSLL 997
             |..|.||.....::.||:..:|..:                                 .:.||.
Mouse   335 -EVLGTGAEVDYLEQFGTSSFKESAW---------------------------------RKQSLY 365

  Fly   998 LKFDPLLG----APVPVNHPNQQEQALQNILGSNQHQNRLLSPTLEEHETSDGNQSFGVISSAKD 1058
            :||||||.    .|:||.......|..:...||.:       ||..|....|......|..||
Mouse   366 VKFDPLLKDSPLRPMPVAPITNSTQDTEEESGSGK-------PTEAELVNLDFLGDLDVPVSA-- 421

  Fly  1059 TAKKWDFKPPV----DRTKKHVKMSVDVIDNDCNKTFDNSNTNTEDKTHNYNDMDELEKKIKNEV 1119
                    ||:    .|.....:..|||:                  .::..|:|.:.     .|
Mouse   422 --------PPLCVLEPRGLLPAEPIVDVL------------------KYSQKDLDAVV-----NV 455

  Fly  1120 TRSEDIEKKLKEGELREEALIKRITEKDKTNAKLNGVIEAYEKAIAELISEKEQQAQLH---ERQ 1181
            .:.|::|.|.|..:|..:.|     |..|:       ::.:||...:.:.|.|:|.:|.   |.:
Mouse   456 MQQENLELKSKYEDLNTKYL-----EMGKS-------VDEFEKIAYKSLEEAEKQRELKEIAEDK 508

  Fly  1182 LQEVQADRDANYHHLTSLETTFSDLHVKYEKSKEMTSQLKSNEESLLAERKQMMDNLRLQEQRYD 1246
            :|:|..:||.....|.|:|.:||||..::||.||:....:.|||||.....:.:..:..:.|||.
Mouse   509 IQKVLKERDQLNADLNSMEKSFSDLFKRFEKRKEVIEGYQKNEESLKKYVGECIVKIEKEGQRYQ 573

  Fly  1247 KMKNHAMQQLEIANKKL-DTYSREHADETKKLKALLKKEEISRVSMTEQLQQKSRENADLLKICE 1310
            .:|.||.::|.:||::: ..:|:..| |...|:|.|:|.::...|:...|:||::|..:|.:||:
Mouse   574 ALKIHAEEKLRLANEEIAQVHSKAQA-EVLALQASLRKAQMQNHSLEMTLEQKTKEIDELTRICD 637

  Fly  1311 ELI 1313
            :||
Mouse   638 DLI 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tacc	NP_001189169.1	TACC	1103..1313	CDD:282818	62/213 (29%)
Tacc3	XP_011239017.1	PRK10263	<23..>274	CDD:236669	60/299 (20%)
		rne	<160..310	CDD:236766	38/179 (21%)
		TACC	444..640	CDD:368238	62/213 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6909
eggNOG	1	0.900	-	-		E1_2C9BM
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002147
OrthoInspector	1	1.000	-	-		otm44090
orthoMCL	1	0.900	-	-		OOG6_106926
Panther	1	1.100	-	-	LDO	PTHR13924
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.770