Protein Alignment tacc and TACC3

DIOPT Version :9

• Sequence 1: NP_001189169.1
• Gene: tacc / 40589
• FlyBaseID: FBgn0026620
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: XP_005247986.1
• Gene: TACC3 / 10460
• HGNCID: 11524
• Length: 842
• Species: Homo sapiens
• Alignment Length: 1137
• Identity: 230/1137 - (20%)
• Similarity: 393/1137 - (34%)
• Gaps: 414/1137 - (36%)

  Fly   255 LAVSQHNNVSYEAMDVDDLNETMEM-----LKDVLNAEDRHLMQTH-ILSVTQ-SKPENNFV--- 309
            |.|||..||..:     :|.:.|::     |:|         .||| |||.:. ||.|..|.
Human    36 LRVSQKENVPPK-----NLAKAMKVTFQTPLRD---------PQTHRILSPSMASKLEAPFTQDD 86

  Fly   310 -----HYHP--NQEQNRVELDQLAKHSKPNSDAKESESLVESVLSEE------------SGTQSF 355
                 :.||  .|::|:    ||.|    ..|||.:..:::..:..:            ||:.|.
Human    87 TLGLENSHPVWTQKENQ----QLIK----EVDAKTTHGILQKPVEADTDLLGDASPAFGSGSSSE 143

  Fly   356 EPKLTLSALD---STKDLAKHQEEMQTNTKDIFQKEKHHPVSSAQVKDAQNPKEPEKALNLKEAS 417
            .....|:.||   |::.....:.:|               ||..:|..:     ||:|:....:|
Human   144 SGPGALADLDCSSSSQSPGSSENQM---------------VSPGKVSGS-----PEQAVEENLSS 188

  Fly   418 SELSTKSAKSLEYPNQEKQFSVAVESMERPCTAISLEQNASP--AMEATEDRTVEELDQMDVDES 480
            ..|             :::.:.|.|::|.||...|..:..:|  |.|..:..|....::
Human   189 YSL-------------DRRVTPASETLEDPCRTESQHKAETPHGAEEECKAETPHGAEE------ 234

  Fly   481 MKVDDATVLNSCRQEQINAHSPVSSKFFLKLCVQNDTDCQDNKMDQKTAGKESALKMTEIELPVE 545
                      .||...:.|.:.|::.             ....:.::..|          ..|::
Human   235 ----------ECRHGGVCAPAAVATS-------------PPGAIPKEACG----------GAPLQ 266

  Fly   546 SVPSASLSPPTPALQAKIIELSLSPPIP-----------THRPK-TAEELEFLALRELPL-PDGV 597
            .:|..:|..|.          .:..|:|           |..|: ||.....:|.|.:.| |...
Human   267 GLPGEALGCPA----------GVGTPVPADGTQTLTCAHTSAPESTAPTNHLVAGRAMTLSPQEE 321

  Fly   598 STAGKVECKQLSHGLVPIVAVLPTPLYLDLKGNTTTASLPEPTSPSFPIKEPAEKQSHFPRSPRA 662
            ..||::.....|.         |..|..|:....|:...|.|       :...|:....|...:|
Human   322 VAAGQMASSSRSG---------PVKLEFDVSDGATSKRAPPP-------RRLGERSGLKPPLRKA 370

  Fly   663 QLEQKDMPYLEEAVVERSSHRKQSDFGVIAKSPIVFELTQPSPEKQ---HLN-ETLPMSEISPTS 723
            .:.|:..|  :|  ||....|..:     .:.|       |.|..:   ||: :.:......|..
Human   371 AVRQQKAP--QE--VEEDDGRSGA-----GEDP-------PMPASRGSYHLDWDKMDDPNFIPFG 419

  Fly   724 SNMTFDSGSITEDKSQKGTENIEPSSTLAVSLGSVDDKQRRTFSVVQPTKEEEEAKSRRTFCMEN 788
            .:            ::.|....:|..:....||             ||..|:..|..    ..|.
Human   420 GD------------TKSGCSEAQPPESPETRLG-------------QPAAEQLHAGP----ATEE 455

  Fly   789 ENPRRTFCMQQNASPAVEATEDTGADEVMDVDISMRADEVAVMKSHQQTWKER-------QAPIS 846
            ..|    |:.|....|  :.|||        .:...|.|....:|     |||       ..|.|
Human   456 PGP----CLSQQLHSA--SAEDT--------PVVQLAAETPTAES-----KERALNSASTSLPTS 501

  Fly   847 --NSPPIPTHQRLNRPPEAISPVSPLGNGTVVLEEQTLSAKEQATLSASDEKDDVFLEHFGAISP 909
              .|.|:||||:                |...||.:..|.::.|.:..:..:.| :||.||..|
Human   502 CPGSEPVPTHQQ----------------GQPALELKEESFRDPAEVLGTGAEVD-YLEQFGTSS- 548

  Fly   910 VSDDMFKTSSASNNQAKFRVNADEETGGKGASAMIRKRSGTAGEQEEIFDAEFHDGVNNQNLILN 974
                 ||.|:                        :||:
Human   549 -----FKESA------------------------LRKQ--------------------------- 557

  Fly   975 SSDFDYLYTKGSNSVPIDRSSLLLKFDPLL----GAPVPVNHPNQQEQALQNILGSNQHQNRLLS 1035
                                ||.|||||||    |.||||      .....::.|:|
Human   558 --------------------SLYLKFDPLLRDSPGRPVPV------ATETSSMHGAN-------- 588

  Fly  1036 PTLEEHETSDGNQSFGVISSAKDTAKKWDF----------KPPVDRTKKHVKMS----VDVIDND 1086
                  ||..|..     ..||  ..::||          .||.........:|    ||::
Human   589 ------ETPSGRP-----REAK--LVEFDFLGALDIPVPGPPPGVPAPGGPPLSTGPIVDLL--- 637

  Fly  1087 CNKTFDNSNTNTEDKTHNYNDMDELEKKIKNEVTRSEDIEKKLKEGELREEALIKRITEKDKTNA 1151
                             .|:..| |:..::.:|..:::..::|:          .|..|....|.
Human   638 -----------------QYSQKD-LDAVVRTQVKATQEENRELR----------SRCEELHGKNL 674

  Fly  1152 KLNGVIEAYEKAIAELISEKEQQAQLHERQLQEVQADRDANYHHLTSLETTFSDLHVKYEKSKEM 1216
            :|..:::.:|:.:.:.:.|.::|.:|.:.::|:|..::|.....|.|:|.:||||..::||.||:
Human   675 ELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEV 739

  Fly  1217 TSQLKSNEESLLAERKQMMDNLRLQEQRYDKMKNHAMQQLEIANKKLDTYSREHADETKKLKALL 1281
            ....:.|||||....:..:..:..:.|||..:|.||.::|::||:::.....:...|...|:|.|
Human   740 IEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASL 804

  Fly  1282 KKEEISRVSMTEQLQQKSRENADLLKICEELI 1313
            :||::...|:.:.::||::||.:|.:||::||
Human   805 RKEQMRIQSLEKTVEQKTKENEELTRICDDLI 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tacc	NP_001189169.1	TACC	1103..1313	CDD:282818	55/209 (26%)
TACC3	XP_005247986.1	TACC	639..836	CDD:282818	55/207 (27%)
		iSH2_PI3K_IA_R	656..>757	CDD:304922	28/110 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6571
eggNOG	1	0.900	-	-		E1_2C9BM
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002147
OrthoInspector	1	1.000	-	-		otm42037
orthoMCL	1	0.900	-	-		OOG6_106926
Panther	1	1.100	-	-	LDO	PTHR13924
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.770