Protein Alignment tacc and tacc2

DIOPT Version :10

• Sequence 1: NP_001189169.1
• Gene: tacc / 40589
• FlyBaseID: FBgn0026620
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: XP_031761067.1
• Gene: tacc2 / 100125117
• XenbaseID: XB-GENE-993299
• Length: 3148
• Species: Xenopus tropicalis
• Alignment Length: 1845
• Identity: 364/1845 - (19%)
• Similarity: 628/1845 - (34%)
• Gaps: 625/1845 - (33%)

  Fly     2 DFLANIIKRPKSIATTGISTNQ--PTTMEA-------------LEAASPADE-CSTPRDKGGVTL 50
            |.|:|:   |.|:..|.|.::.  ||:.|.             ||.:|  || |||..::..:..
 Frog  1400 DILSNV---PWSVEETEILSDMAYPTSKETEILFDIPCLAPTKLECSS--DEPCSTTTERESLPS 1459

  Fly    51 VSAHLDSLLESASEELQRLEGKHCELFMESIS-NPLPAPEDSTDS------------REEIQ--- 99
            .:..|...|....::|:.||.....:..|:.| ..|..|...|:.            .|:.|
 Frog  1460 DAIPLPVQLTFQEQDLRSLEPNGTIILDENNSVYTLEIPHQRTEMVSVDTHGSKYGIMEQTQPPL 1524

  Fly   100 KFLSEINFNLNQVSANEMEH-LQAMSGELSPLAVKPSPKPTSMDQQKAMAAALGHQTAVPGGLKP 163
            :.|.|:.|          || ::.:..|.:..||....||.|:|...       .:||.|....|
 Frog  1525 ECLKELAF----------EHPIEVLEQESAAKAVSEEKKPGSLDLDT-------EETAEPASKGP 1572

  Fly   164 EDDLVPKFGGLP--EFDETQIPELAPLSTDMDTQLK------------------SNHSDSDVFVE 208
            .:.:......||  |...:.:.::.|||....|:.|                  |...|.::...
 Frog  1573 ANKMEKPLPLLPIGEVKISSLLDVEPLSLQDATEKKKLTSGEPAGNVEEQTCRESASEDKELTFT 1637

  Fly   209 CLSLHSERYTGDRSELEAYSSALNDVLEQQLSMTSVSTLGAEFNDPLAVSQHNNVSYEAMDVDDL 273
            ......:.||.|.:..|...::...|.:|.  ..:::..||:.|:|:.      :.|...|...:
 Frog  1638 NAVTEDKTYTLDSATDETEHTSTMPVTKQM--DRALADHGAKGNEPIL------LKYVVKDKPCM 1694

  Fly   274 ----NETMEMLKDV----------LNAEDRHLMQTHILSVTQSKPENNFVHY-------HPNQEQ 317
                ....|.:||.          ...||:           |:..|..|:..       |.|:::
 Frog  1695 PVKHGSKKEKIKDAFPKPEPAIYPFKYEDK-----------QTSKETAFIDQNFSDIDSHTNEKE 1748

  Fly   318 NRV------ELDQLAKHSKPNS------------DAKESESLVESVLSEESGTQSFEPKLTLSAL 364
            ..|      |.:|.|:.::|.|            .|||.|..:|..:.::....|.:|     |:
 Frog  1749 ATVPVTKETETEQGAQRTEPTSVDLMKKKEFSSAAAKELEPTLEENVPKQKALTSVDP-----AV 1808

  Fly   365 DSTKDLAKH--QEEMQTNTKDIFQKEKHHPVSSAQVKDAQNPKEPEKAL------NLKEASSELS 421
            :.|:..:.|  ..||:...::...:||  |::..:....:|.....:.|      ||||...|.:
 Frog  1809 NETERTSAHAVSTEMEYAFEEHASEEK--PLAPVEPATKENELTSVETLTNDTGPNLKEHVPEKT 1871

  Fly   422 TKSAKSLEYPNQEKQFS---VAVESMERPCTAISLEQNA--------------------SPAMEA 463
              ...|::...:||:||   |..:.||.     :||:||                    |..||:
 Frog  1872 --EITSVDIAQKEKEFSSPAVVTKEMEP-----TLEENASREKNAKDREHISTETKGKESSLMES 1929

  Fly   464 T--------------------------------EDRTVEELDQMDVDESMKVDDATVL------- 489
            |                                .|...:|::....|::.|:.:.|:.
 Frog  1930 TAKEMNMTSIDKYNIEEEQVPIEAIVEHKTLSFTDSVTKEIEATSTDQTHKMMEFTMTDHDTNKN 1994

  Fly   490 ---NSCRQEQINAHSPVSSKFFLK----------LCVQNDTDCQDNKMDQKTAGKESALKMTEIE 541
               :||...:...|:  ||..|.|          |..|..:...:.....:...||:|.|..::.
 Frog  1995 QLSSSCLAIKEKGHT--SSGPFTKETKPSLAESVLKEQGPSSVDNVSTQMEVVSKENATKEKDLH 2057

  Fly   542 LPVESVPSASLSP-----PTPALQAKIIELSLSP----PIPTHRPKTAEELEFLALRE--LPLPD 595
            ..|.|.|..|.|.     |:|.      ..:|:|    |:..|...||..   .|.|.  .|.||
 Frog  2058 FMVLSPPPLSKSTSDSQVPSPG------GPTLNPVHDKPLSPHMDATAVN---TATRSPTFPAPD 2113

  Fly   596 GVSTAGKVECKQLSHG-----------LVPIVAVLPTPLYLDLKGNTTTAS--------LPEPTS 641
            ..|...|:  :.:.|.           ..|...|.|....|..:|..|..|        .||.|:
 Frog  2114 SYSFTQKL--RSVLHSERTSTRKSATPTSPEPLVRPASPRLVAEGTITQRSSDSEEAFETPESTT 2176

  Fly   642 P-------SFPIKEPAEKQSHFPRSPRAQLEQKDMPYLEEAVVERSSHRKQSDF----------- 688
            |       |||....|::|         :.:|..:.::||.:.:.|...:.:|.
 Frog  2177 PVKSAPPVSFPPLSEAQEQ---------EQQQPLVQHVEEEITQPSLPAEDTDSVFAADSVSVAD 2232

  Fly   689 --GVI---AKSPI---------VFELTQP------------SPEKQHLNET--LPM------SEI 719
              |||   .:||.         ||:..:|            :||...::.:  :|:      |:.
 Frog  2233 EPGVIDEVNQSPFRAPSRSFSAVFDEDKPIASSGAYNLDFTAPETDDISSSSEVPVRARRKSSDS 2297

  Fly   720 SPTSSNMTFDSGSI------TEDK--SQKGTENIEPS--STLAVSLGSVDDKQRRTFSVVQPTKE 774
            .||..|....|.|:      .|:.  ||.|:::...|  .|..|..||:..|.......::|...
 Frog  2298 VPTGRNTLSRSLSLQAADFQNEEAFGSQGGSDSACSSLRRTKKVRTGSLKKKTSSAKKQIEPAGS 2362

  Fly   775 EEEA----------KSRRTFCMENENPRRT---------FCMQQNASPAVEATE-DTGADEVMD- 818
            :||.          |:.:.|..::..|.::         ..:|.:..|:|...| ..|.|.|:|
 Frog  2363 KEEVAGNSEETDLDKNLQRFSSDSPTPPKSDPDLEPQEISALQSSNIPSVSDQECSVGGDVVVDP 2427

  Fly   819 ----------------------------------VDISMRADEVAVMKSHQQTWKERQA------ 843
                                              :..|:|.:.....::|:.....|:.
 Frog  2428 CAPIETVTASPSLDSHRGPEVPNADTEGPEKTGIIGQSVRLEFDYSEEAHEGQPPTRKGKKPSGK 2492

  Fly   844 -PISNSPPIPTHQRLNRPPEAISPVS------PLGNGTVVLEEQTLSAKEQATLSASDEKDDVFL 901
             |:....|....::.:.||.:.:|:|      |:|.|:................|:||:..|..|
 Frog  2493 MPLRKPKPKKAVEKPDAPPGSPTPISVEPDDIPIGKGSYTYNLDKWDDPNFNPFSSSDKMPDAPL 2557

  Fly   902 ------EHFGAISPVSDDMFKT-------SSA-------SNNQAK----------FRVN------ 930
                  |.|..|:..|:...||       |||       ||..||          |||.
 Frog  2558 TNQDPPEPFKPITHRSESPAKTPASFEIPSSAAEQNIGESNKPAKKKKTPLKTDTFRVKKSPKRS 2622

  Fly   931 ----------------------------ADEETGGKGASAMIRKRSGTAGEQEE----------- 956
                                        .|||   |.||::.:|.|..|.:.|.
 Frog  2623 PVSENGTEELTLLPKSEIPPVIASEDHATDEE---KLASSVGQKWSCMAVDLEPEKKDYPEPSDL 2684

  Fly   957 ---IFDAEFHDGVNNQNLILNSSDFDYLYTKGSNS----VPIDRSSLLLKFD------------- 1001
               :.:.:||....::....||.:.:|:...|:.|    :| ...||.|.|:
 Frog  2685 SNFVNENQFHTSTTDETEFGNSYNIEYMEKTGTCSPLQDIP-QTQSLYLMFEGSQESPGKTPSKF 2748

  Fly  1002 -----------------PLL--GAPV-------PVNHPNQQEQ--------------------AL 1020
                             ||.  ..|:       |:..|.|:::                    |.
 Frog  2749 SETSTPGTGSTFDGLEPPLCTRSPPIMQDSIRQPLERPRQRDEETGGLGCGKMELGSPEDAYVAA 2813

  Fly  1021 QNILGSNQHQNRL------LSPTLEEHETSDGNQSFG---------------VISSAKDTAKKWD 1064
            :.:|.....|..|      |.|.|.|...    |:|.               .::.||..::
 Frog  2814 ETLLSRISQQAALCDQLSYLEPDLAEKNP----QAFAQKLQEELEFAAMRIEALTLAKHISQ--- 2871

  Fly  1065 FKPPVDRTKKHVKM-----SVDVIDNDCNKTFDNSNTNTE--DKTH---NYNDMDELEKKIKNEV 1119
                ...:.:|.::     |..|..:.||....:|....|  |.|.   ::|.:  ..:.:..|.
 Frog  2872 ----ASLSSQHPELLLWAPSELVCRDSCNSVSLSSRLQCEAIDPTDVGLSHNSL--YSRTVAMET 2930

  Fly  1120 TRS--------EDIEKKLKEGELREEALIKRITEKDKTNAKLNG----------VIEAYEKAIAE 1166
            ..|        .|::..|   ::..|.::.:..|.|....|..|          ::..|||.||:
 Frog  2931 GSSALLHPFQQSDVDAAL---QIAREEIVAKEREVDDWKKKYEGSHCEVVEMRKIVAEYEKTIAQ 2992

  Fly  1167 LI---SEKEQQAQLHERQLQEVQADRDANYHHLTSLETTFSDLHVKYEKSKEMTSQLKSNEESLL 1228
            :|   .:::::..:....:|::..:::.....|.|:|.:.:||..:|||.||:....:.|||.|.
 Frog  2993 MIGSPEDEQREKSVSHHTVQQLILEKEQALSDLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLK 3057

  Fly  1229 AERKQMMDNLRLQEQRYDKMKNHAMQQLEIANKKLDTYSREHADETKKLKALLKKEEISRVSMTE 1293
            ...::.:..::.:||||..:|.||.::|:.||.::.....:...|....:|.|:||::...::..
 Frog  3058 KCAQEYLARVKKEEQRYHALKIHAEEKLDRANAEIAQVRSKSQQEQVAYQASLRKEQLRVDALER 3122

  Fly  1294 QLQQKSRENADLLKICEELIYGKGQ 1318
            .|:||::|..:|.|||:|||...|:
 Frog  3123 TLEQKNKEIEELTKICDELIAKMGK 3147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tacc	NP_001189169.1	TACC_C	1103..1313	CDD:461517	55/233 (24%)
tacc2	XP_031761067.1	PHA03307	2069..>2521	CDD:223039	89/471 (19%)
		PTZ00449	<2399..2702	CDD:185628	54/305 (18%)
		TACC_C	2939..3142	CDD:461517	52/205 (25%)