DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep2 and ECE2

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001093590.1	Gene:	ECE2 / 9718	HGNCID:	13275	Length:	811	Species:	Homo sapiens

Alignment Length:	708	Identity:	251/708 - (35%)
Similarity:	393/708 - (55%)	Gaps:	45/708 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 SGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQ 144
            |...|||:.||..|..:|..:...|.||::||:|:||.::....:||.:...:||:.:.|:.|..
Human   136 SHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAI 200

  Fly   145 LKDII------TAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSW 203
            ||.::      ::...|.:.:.|      |.:|:....||.||.:|:..:.|::|||.:.  ..|
Human   201 LKHLLENTTFNSSSEAEQKTQRF------YLSCLQVERIEELGAQPLRDLIEKIGGWNIT--GPW 257

  Fly   204 NADDSWTWQEQVK----KFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLAL-SRE-YLVKG 262
            :.|:   :.|.:|    .:|...|...|     |..|.::|...:|.:|||.|.| ||: ||.:.
Human   258 DQDN---FMEVLKAVAGTYRATPFFTVY-----ISADSKSSNSNVIQVDQSGLFLPSRDYYLNRT 314

  Fly   263 FNETLVTAYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTPAQ 327
            .||.::|||..||.::.:|.|......:.::...||.|:.||||:.|.::||:..::|:..:.::
Human   315 ANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISE 379

  Fly   328 LQAAYPYVQWVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRIHGFS 392
            |||..|.:.|:::::.|| ..|.:::.|.:.:....:.:.:.:|:.:|...::.||:.|.:...:
Human   380 LQALAPSMDWLEFLSFLL-SPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKT 443

  Fly   393 VGFLSEEFRKRQLQYATALSGRQEQ-EARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKHF 456
            ...|...|...|.:....|.|.::. ..||:.|:    |:.|       |:||.::|||:|...|
Human   444 TSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCI----SNTD-------DALGFALGSLFVKATF 497

  Fly   457 HKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYYA 521
            .:.||..|..|::|||..|.:.|.::.|||.||::.||.|..::...||:||.:|:.::|...|.
Human   498 DRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYD 562

  Fly   522 KLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGILQ 586
            ..:|..|.:|::.|.:..|......::||.|.::..|  ...|..|||:|...:|.|.|||||||
Human   563 GYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQW--SMTPQTVNAYYLPTKNEIVFPAGILQ 625

  Fly   587 GHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQY 651
            ..|:....||.:|||.||.|:|||:||.||||||::|.:||||.||..::..|:.....|:.|||
Human   626 APFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQY 690

  Fly   652 GNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPEQMFWVAAGQ 716
            ..|  :..|..|||..|.|||||||||:|.:|.||:.|..|||.|.:||.:..|..|:|:|...|
Human   691 NQY--QVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQ 753

  Fly   717 TWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            .||:....||....:.|..|||:.|||||:|||.:||.:.|.||.||||||.|.||||
Human   754 VWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	239/680 (35%)
ECE2	NP_001093590.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..64
ECE2	NP_001093590.1	M13	160..809	CDD:189000	239/680 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.930