DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep2 and ECEL1

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_004817.2	Gene:	ECEL1 / 9427	HGNCID:	3147	Length:	775	Species:	Homo sapiens

Alignment Length:	774	Identity:	246/774 - (31%)
Similarity:	405/774 - (52%)	Gaps:	58/774 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PNWWRRRNKLEKSLLVSLGIMFVVLATGFGLWIGKVLRTSPPSNPQATALHGDSTTINQVPTGTA 72
            |.|.||...|...|:.:.|:..::.|.....::|.|                            |
Human    53 PRWNRREVCLLSGLVFAAGLCAILAAMLALKYLGPV----------------------------A 89

  Fly    73 SKGKSGDSGDVCLTQECIHTASTVL-RKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSV 136
            :.|.:...|  |..::....|:..| ..:...::||.:||.||||.:|....|||||::..|.:.
Human    90 AGGGACPEG--CPERKAFARAARFLAANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAA 152

  Fly   137 ISDKLQEQLKDIITAERPETEP--KHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIK 199
            |.::.:|:|:.::.  ||...|  ...|.....:::|::...||.|||.|:..|.|..|||.| .
Human   153 IGEQNEERLRRLLA--RPGGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDL-G 214

  Fly   200 GDSWNADDSWTWQEQVKKFRTAG-FSMDYIIDFSIGVDLQNSTKRLIDLDQSSLALSRE--YLVK 261
            |.......:..|......::..| :|...:...::.:|.:||::.:|.:||..|.|...  ||.:
Human   215 GAEERPGVAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQ 279

  Fly   262 G-FNETLVTAYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNLRTP 325
            . .:|.::.||..:|..:..|.||:....|.:.:|.:|.::|...:|..::.||:.|.:||..|.
Human   280 DEDSEKILAAYRVFMERVLSLLGADAVEQKAQEILQVEQQLANITVSEHDDLRRDVSSMYNKVTL 344

  Fly   326 AQLQAAYPYVQWVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWRIHG 390
            .|||...|:::|...::.:..|  :.:|:|.:.|....:.:.:.:|:..||.||:.||:.||:..
Human   345 GQLQKITPHLRWKWLLDQIFQE--DFSEEEEVVLLATDYMQQVSQLIRSTPHRVLHNYLVWRVVV 407

  Fly   391 FSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGKH 455
            .....||..||:...:.|..:.|..:.:...:.|:..|..           ..|:::|:|:|.:|
Human   408 VLSEHLSPPFREALHELAQEMEGSDKPQELARVCLGQANR-----------HFGMALGALFVHEH 461

  Fly   456 FHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAYY 520
            |...|||...::|.:|:.:....|:|::||||:|:..|:.||..|...:||||.:|..:.:...|
Human   462 FSAASKAKVQQLVEDIKYILGQRLEELDWMDAETRAAARAKLQYMMVMVGYPDFLLKPDAVDKEY 526

  Fly   521 AKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQFPAGIL 585
             :.::....||::.|....|....|..|:|..|:|:.|:  ..|..:||:|...:|.:.||||||
Human   527 -EFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSTWL--LPPQALNAYYLPNKNQMVFPAGIL 588

  Fly   586 QGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQ 650
            |...::...|:.:|:|.||.:||||:|||:||.|.|:|..|||..||...:...:|.||:||:..
Human   589 QPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLRKAECIVRL 653

  Fly   651 YGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPEQMFWVAAG 715
            |.|:|  .....:||.:|.||||||.||:|.:|.||::|..:||||..||.|.||.:|:|::|..
Human   654 YDNFT--VYNQRVNGKHTLGENIADMGGLKLAYHAYQKWVREHGPEHPLPRLKYTHDQLFFIAFA 716

  Fly   716 QTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            |.||.|.|.:|:.:::.|..|:|..:|||||:|..::|.:.||||:.|||||..||.||
Human   717 QNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPAHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	227/673 (34%)
ECEL1	NP_004817.2	M13	120..773	CDD:341056	227/673 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.830