DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep2 and Ece1

DIOPT Version :9

Sequence 1:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_006239337.1	Gene:	Ece1 / 94204	RGDID:	620293	Length:	769	Species:	Rattus norvegicus

Alignment Length:	779	Identity:	279/779 - (35%)
Similarity:	414/779 - (53%)	Gaps:	82/779 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 WRRRNKLEKSLLVSLGIMFVVLATGF-----GLWIGKVLRTSPPSNPQATALHGDSTTINQVPTG 70
            |..|..:||.|:|    :..:||.|.     .|.|....||.|
  Rat    58 WAARTSVEKRLVV----LVTLLAAGLVACLAALGIQYRTRTPP---------------------- 96

  Fly    71 TASKGKSGDSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFS 135
                        ||||:.|:...|::|..|.|.|:||.:|:.:|||.:::...:||......|||
  Rat    97 ------------VCLTEACVSVTSSILNSMDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFS 149

  Fly   136 VISDKLQEQLKDII---TAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPL 197
            .:.:..|..:|.::   ||...|.|.|    ..:.|:||||:|.||.|..:|:..:.|:||||.:
  Rat   150 NLWEHNQAIIKHLLENSTASASEAEKK----AQVYYRACMNETRIEELRAKPLMELIEKLGGWNI 210

  Fly   198 IKGDSWNADDSW--TWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLAL-SRE-Y 258
            .  ..| |.|::  |.|.....:||:.|...|     :..|.:||...:|.:|||.|.| ||: |
  Rat   211 T--GPW-AKDNFQDTLQVVTAHYRTSPFFSVY-----VSADSKNSNSNVIQVDQSGLGLPSRDYY 267

  Fly   259 LVKGFNETLVTAYYKYMVDIA-VLFGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYNL 322
            |.|..||.::|.|..|||.:. :|.|.:.|..:.::...|:||.|||||:.|.||||:...:|:.
  Rat   268 LNKTENEKVLTGYLNYMVQLGKLLGGGDEDSIRPQMQQILDFETALANITIPQEKRRDEELIYHK 332

  Fly   323 RTPAQLQAAYPYVQWVDYMNALL-PEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFW 386
            .|.|:||...|.:.|:.::||:. |..:|  |.|.|.:....:...:..|:..|.|.::.|||.|
  Rat   333 VTAAELQTLAPAINWLPFLNAIFYPVEIN--ESEPIVVYDKEYLRQVSTLINSTDKCLLNNYMMW 395

  Fly   387 RIHGFSVGFLSEEFRKRQLQYATALSGRQEQ-EARWKECVDIATSSMDEVCEDDFDSLGISVGSL 450
            .:...:..||.:.|:....::...:.|.::. ..|||.||           .|..::||.::|.:
  Rat   396 NLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCV-----------SDTENNLGFALGPM 449

  Fly   451 YVGKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEK 515
            :|...|.:|||..|.|::.||:..|.:.|..:.|||..|::.||.|..::...||||:.::|.::
  Rat   450 FVKATFAEDSKNIASEIILEIKKAFEESLSTLKWMDEDTRRSAKEKADAIYNMIGYPNFIMDPKE 514

  Fly   516 LAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSIQF 580
            |...:......||.|||:.:....|....:.::||...|:..|  ...|.:|||:||..:|.|.|
  Rat   515 LDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQW--SMTPPMVNAYYSPTKNEIVF 577

  Fly   581 PAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAK 645
            ||||||..|:....|..:|||.||.|:|||:||.||||||::|..||||.||...:.:|:..:.:
  Rat   578 PAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTE 642

  Fly   646 CIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPEQMF 710
            |:::||.||:  ..|..:||.:|.|||||||||:|.:|.||:.|.:|:|.|..||.|..|..|:|
  Rat   643 CMVQQYNNYS--VNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQILPTLGLTSNQLF 705

  Fly   711 WVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774
            ::...|.||:....||....:.|..||||.|||:|||||.|:|::.|.||.||||||..|||||
  Rat   706 FLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep2	NP_001246914.1	M13	104..772	CDD:189000	252/677 (37%)
Ece1	XP_006239337.1	PepO	105..769	CDD:226118	258/692 (37%)
Ece1	XP_006239337.1	M13	118..767	CDD:189000	252/677 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830